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dc.contributor.authorMena-Vazquez, N.
dc.contributor.authorFernandez-Nebro, A.
dc.contributor.authorPego Reigosa, José María 
dc.contributor.authorGalindo, M.
dc.contributor.authorMelissa-Anzola, A.
dc.contributor.authorUriarte-Isacelay, E.
dc.contributor.authorOlive-Marques, A.
dc.contributor.authorAurrecoechea, E.
dc.contributor.authorFreire, M.
dc.contributor.authorTomero, E.
dc.contributor.authorGarcia-Villanueva, M. J.
dc.contributor.authorStoye, C.
dc.contributor.authorSalas-Heredia, E.
dc.contributor.authorBernal-Vidal, J. A.
dc.contributor.authorSalgado Pérez, Eva 
dc.contributor.authorBlanco, R.
dc.contributor.authorJavier Novoa, F.
dc.contributor.authorIbanez-Barcelo, M.
dc.contributor.authorTorrente-Segarra, V.
dc.contributor.authorNarvaez, J.
dc.contributor.authorCalvet, J.
dc.contributor.authorMoriano Morales, C.
dc.contributor.authorRamon Vazquez-Rodriguez, T.
dc.contributor.authorGarcia de la Pena, P.
dc.contributor.authorBohorquez, C.
dc.contributor.authorAndreu-Sanchez, J. L.
dc.contributor.authorCobo-Ibanez, T.
dc.contributor.authorBonilla, G.
dc.contributor.authorLozano-Rivas, N.
dc.contributor.authorMontilla, C.
dc.contributor.authorToyos, F. J.
dc.contributor.authorDe la Fuente, J. L. M.
dc.contributor.authorExposito, L.
dc.contributor.authorRuiz-Lucea, M. E.
dc.contributor.authorVals, E.
dc.contributor.authorManero-Ruiz, J.
dc.contributor.authorBernal-Vidal, J. A.
dc.contributor.authorRua-Figueroa, I.
dc.date.accessioned2022-01-27T10:40:30Z
dc.date.available2022-01-27T10:40:30Z
dc.date.issued2019
dc.identifier.issn1462-0324
dc.identifier.otherhttp://diposit.ub.edu/dspace/bitstream/2445/171742/1/Mena-VazquezN.pdfes
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31808534es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15962
dc.description.abstractOBJECTIVES: This article estimates the frequency of polyautoimmunity and associated factors in a large retrospective cohort of patients with SLE. METHODS: RELESSER (Spanish Society of Rheumatology Lupus Registry) is a nationwide multicentre, hospital-based registry of SLE patients. This is a cross-sectional study. The main variable was polyautoimmunity, which was defined as the co-occurrence of SLE and another autoimmune disease, such as autoimmune thyroiditis, RA, scleroderma, inflammatory myopathy and MCTD. We also recorded the presence of multiple autoimmune syndrome, secondary SS, secondary APS and a family history of autoimmune disease. Multiple logistic regression analysis was performed to investigate possible risk factors for polyautoimmunity. RESULTS: Of the 3679 patients who fulfilled the criteria for SLE, 502 (13.6%) had polyautoimmunity. The most frequent types were autoimmune thyroiditis (7.9%), other systemic autoimmune diseases (6.2%), secondary SS (14.1%) and secondary APS (13.7%). Multiple autoimmune syndrome accounted for 10.2% of all cases of polyautoimmunity. A family history was recorded in 11.8%. According to the multivariate analysis, the factors associated with polyautoimmunity were female sex [odds ratio (95% CI), 1.72 (1.07, 2.72)], RP [1.63 (1.29, 2.05)], interstitial lung disease [3.35 (1.84, 6.01)], Jaccoud arthropathy [1.92 (1.40, 2.63)], anti-Ro/SSA and/or anti-La/SSB autoantibodies [2.03 (1.55, 2.67)], anti-RNP antibodies [1.48 (1.16, 1.90)], MTX [1.67 (1.26, 2.18)] and antimalarial drugs [0.50 (0.38, 0.67)]. CONCLUSION: Patients with SLE frequently present polyautoimmunity. We observed clinical and analytical characteristics associated with polyautoimmunity. Our finding that antimalarial drugs protected against polyautoimmunity should be verified in future studies.en
dc.language.isoenges
dc.rightsAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.meshAdult*
dc.subject.meshMiddle Aged*
dc.subject.meshHumans*
dc.subject.meshRegistries*
dc.subject.meshAntirheumatic Agents*
dc.subject.meshCross-Sectional Studies*
dc.subject.meshYoung Adult*
dc.subject.meshAutoimmune Diseases*
dc.subject.meshHydroxychloroquine*
dc.subject.meshAutoimmunity*
dc.titleHydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registryen
dc.typeArtigoes
dc.identifier.doi10.1093/rheumatology/kez562
dc.identifier.pmid31808534
dc.identifier.sophos32699
dc.issue.number-es
dc.journal.titleRHEUMATOLOGYes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Ourense, Verín e O Barco de Valdeorras - Complexo Hospitalario Universitario de Ourense::Complexo Hospitalario Universitario de Ourensees
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Reumatoloxíaes
dc.rights.accessRightsopenAccesses
dc.subject.decsautoinmunidad*
dc.subject.decsadulto joven*
dc.subject.decsmediana edad*
dc.subject.decshumanos*
dc.subject.decsestudios transversales*
dc.subject.decsantirreumáticos*
dc.subject.decsadulto*
dc.subject.decssistema de registros*
dc.subject.decshidroxicloroquina*
dc.subject.decsenfermedades autoinmunes*
dc.subject.keywordCHUOes
dc.subject.keywordCHUVIes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales


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Atribución-NoComercial 4.0 Internacional
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