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dc.contributor.authorRodríguez Alonso, Andrea
dc.contributor.authorCasas Pais, Alba
dc.contributor.authorRoca Lema, Daniel
dc.contributor.authorGraña Suárez, Begoña 
dc.contributor.authorRomay Cousido, Gabriela 
dc.contributor.authorFigueroa Conde-Valvís, Angélica
dc.date.accessioned2022-03-04T07:46:08Z
dc.date.available2022-03-04T07:46:08Z
dc.date.issued2020
dc.identifier.issn2072-6694
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/33114139es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16154
dc.description.abstractThe epithelial-mesenchymal plasticity (EMP) is a process by which epithelial cells acquire the ability to dynamically switch between epithelial and mesenchymal phenotypic cellular states. Epithelial cell plasticity in the context of an epithelial-to-mesenchymal transition (EMT) confers increased cell motility, invasiveness and the ability to disseminate to distant sites and form metastasis. The modulation of molecularly defined targets involved in this process has become an attractive therapeutic strategy against cancer. Protein degradation carried out by ubiquitination has gained attention as it can selectively degrade proteins of interest. In the ubiquitination reaction, the E3 ubiquitin-ligases are responsible for the specific binding of ubiquitin to a small subset of target proteins, and are considered promising anticancer drug targets. In this review, we summarize the role of the E3 ubiquitin-ligases that control targeted protein degradation in cancer-EMT, and we highlight the potential use of the E3 ubiquitin-ligases as drug targets for the development of small-molecule drugs against cancer.en
dc.language.isoenes
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleRegulation of Epithelial-Mesenchymal Plasticity by the E3 Ubiquitin-Ligases in Canceren
dc.typeJournal Articlees
dc.authorsophosRodríguez-Alonso, Andrea;Casas-Pais, Alba;Roca-Lema, Daniel;Graña, Begoña;Romay, Gabriela;Figueroa, Angélica
dc.identifier.doi10.3390/cancers12113093
dc.identifier.pmid33114139
dc.identifier.sophos35561
dc.issue.number11es
dc.journal.titleCancers (Basel)es
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Oncoloxía médica
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC)
dc.relation.publisherversionhttps://mdpi-res.com/d://attachment/cancers/cancers-12-03093/article://deploy/cancers-12-03093.pdfes
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUACes
dc.subject.keywordINIBIC
dc.typefidesArtículo de Revisiónes
dc.typesophosArtículo de Revisiónes
dc.volume.number12es


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Atribución 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución 4.0 Internacional