Pentraxin 3 (PTX3): A Molecular Marker of Endothelial Dysfunction in Chronic Migraine

Abstract

Even though endothelial dysfunction is known to play a role in migraine pathophysiology, studies regarding levels of endothelial biomarkers in migraine have controversial results. Our aim was to evaluate the role of pentraxin 3 (PTX3) and soluble tumour necrosis factor-like weak inducer of apoptosis (sTWEAK) as potential biomarkers of endothelial dysfunction in chronic migraine (CM). We performed a case-control study including 102 CM patients and 28 control subjects and measured serum levels of markers of endothelial dysfunction (PTX3 and sTWEAK) and inflammation [high-sensitivity C-reactive protein (hs-CRP)] as well as brachial artery flow-mediated dilation (FMD) during interictal periods. Interictal serum levels of PTX3 and sTWEAK were higher in CM patients than in controls (1350.6 +/- 54.8 versus 476.1 +/- 49.4 pg/mL, p < 0.001 and 255.7 +/- 21.1 versus 26.4 +/- 2.6 pg/mL, p < 0.0001; respectively). FMD was diminished in CM patients compared to controls (9.6 +/- 0.6 versus 15.2 +/- 0.9%, p < 0.001). Both PTX3 and sTWEAK were negatively correlated with FMD (r = -0.508, p < 0.001 and r = -0.188, p = 0.033; respectively). After adjustment of confounders, PTX3 remained significantly correlated to FMD (r = -0.250, p = 0.013). Diagnosis of CM was 68.4 times more likely in an individual with levels of PTX3 >/= 832.5 pg/mL, suggesting that PTX3 could be a novel biomarker of endothelial dysfunction in CM.