Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1

Poveda López, Eva; Fitzgerald, Wendy; Martínez Reglero, Cristina; Perez Gonzalez, Alexandre; Mariño Callejo, Ana Isabel; Álvarez Díaz, Hortensia; Valcarce Pardeiro, Nieves; Llibre, Josep Maria; Moreno Guillén, Santiago; Muñoz Fernández, Maria Angeles; Ruiz-Mateos, Ezequiel; Margolis, Leonid; Lederman, Michael M; Freeman, Michael L
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URI: http://hdl.handle.net/20.500.11940/19782
PMID: 36790818
ESSN: 1537-6613
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Date issued
2023-06-15
Journal title
The Journal of infectious diseases
Type of content
Artigo
DeCS
interleucina-18 | linfocitos T CD4-positivos | enfermedades transmisibles | infecciones por VIH | humanos | seropositividad al VIH | VIH | VIH-1 | interleucina 3 | citocinas
MeSH
Interleukin-18 | Spain | Extracellular Vesicles | HIV Seropositivity | Humans | HIV | Interleukin-3 | HIV Infections | Communicable Diseases | Cytokines | Elite Controllers | HIV-1 | CD4-Positive T-Lymphocytes
Abstract
Plasma extracellular vesicle (EV)-associated cytokines were quantified in people with HIV (PWH) with different virological control status, including elite controllers (EC) who maintain persistent control (PC) or not (TC). Cytokine signatures and pathways were determined for each group. Median EV-associated cytokine levels were higher among PWH than HIV-uninfected. EC showed the highest levels of EV-associated cytokines among PWH with PC levels higher than TC levels. IL-18 levels best distinguished PWH from uninfected controls, and EC from ART-treated, and IL-3 distinguished PC from TC. The role of EV-cytokines in intercellular communication and endogenous control of HIV expression should be investigated further.
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional