The Obestatin/GPR39 System Is Up-regulated by Muscle Injury and Functions as an Autocrine Regenerative System

Gurriarán Rodríguez, Uxía; Santos Zas, Icía; AL-MASSADI IGLESIAS, OMAR; Seoane Mosteiro, Carlos; Beiroa Tarrío, Daniel; Nogueiras Pozo, Rubén; Crujeiras Martínez, Ana Belén; Seoane Camino, Luisa Maria; Señaris Rodriguez, Jose; García-Caballero, Tomás; Gallego, Rosalia; Casanueva Freijo, Felipe; Pazos Randulfe, Yolanda; Pérez Camiña, Jesús
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Date issued
2012
Journal title
JOURNAL OF BIOLOGICAL CHEMISTRY
Type of content
Artigo
Abstract
Background: Satellite cell activation is orchestrated by several signals, which induce their differentiation into skeletal muscle fibers. Results: Obestatin and the GPR39 receptor exert an autocrine role on the control of myogenesis. Conclusion: Our data indicate that obestatin/GPR39 is an injury-regulated signal that functions as a myogenic regenerative system. Significance: Strategies to enhance obestatin-mediated signaling could be useful in treating trauma-induced muscle injuries and skeletal muscle myopathies.
Atribución 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución 4.0 Internacional