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Elevated 4-aminobiphenyl and 2,6-dimethylaniline hemoglobin adducts and increased risk of bladder cancer among lifelong nonsmokers-the shanghai bladder cancer study

Tao, L.; Day, B. W.; Hu, B.; Xiang, Y. B.; Wang, R.; Stern, M. C.; Gago Dominguez, Manuela; Cortessis, V. K.; Conti, D. V.; Van Den Berg, D.; Pike, M. C.; Gao, Y. T.; Yu, M. C.; Yuan, J. M.
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URI: http://hdl.handle.net/20.500.11940/3767
PMID: 23539508
DOI: 10.1158/1055-9965.EPI-12-1447
ISSN: 1055-9965
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Texto completo disponible por cortesía de Cancer Epidemiol Biomarkers Prev . 2013 May;22(5):937-45. (292.3Kb)
Fecha de publicación
2013
Título de revista
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
Tipo de contenido
Artigo
MeSH
Aged | Aniline Compounds | Biomarkers, Tumor | Case-Control Studies | Female | Hemoglobins | Humans | Male | Middle Aged | Risk Factors | Smoking | Urinary Bladder Neoplasms
Resumen
BACKGROUND: 4-Aminobiphenyl (ABP) is an established human bladder carcinogen, with tobacco smoke being a major source of human exposure. Other arylamine compounds, including 2,6-dimethylaniline (2,6-DMA), have been implicated as possible human bladder carcinogens. Hemoglobin adducts of 4-ABP and 2,6-DMA are validated biomarkers of exposure to those compounds in humans. METHODS: The Shanghai Bladder Cancer Study enrolled 581 incident bladder cancer cases and 604 population controls. Each participant was solicited for his/her history of tobacco use and other lifestyle factors and donation of blood and urine specimens. Red blood cell lysates were used to quantify both hemoglobin adducts of 4-ABP and 2,6-DMA. Urine samples were used to quantify total cotinine. ORs and 95% confidence intervals (CI) for bladder cancer were estimated using unconditional logistic regression methods. RESULTS: Among lifelong nonsmokers, ORs (95% CIs) of bladder cancer for low (below median of positive values) and high versus undetectable levels of 2,6-DMA hemoglobin adducts were 3.87 (1.39-10.75) and 6.90 (3.17-15.02), respectively (Ptrend < 0.001). Similarly, among lifelong nonsmokers, ORs (95% CIs) of bladder cancer for third and fourth versus first/second quartiles of 4-ABP hemoglobin adducts was 1.30 (0.76-2.22) and 2.29 (1.23-4.24), respectively (Ptrend = 0.009). The two associations were independent of each other. CONCLUSION: Hemoglobin adducts of 4-ABP and 2,6-DMA were significantly and independently associated with increased bladder cancer risk among lifelong nonsmokers in Shanghai, China. IMPACT: The findings of the present study in China with previous data in Los Angeles, California strongly implicate arylamines as potential causal agents of human bladder cancer.

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