TY  - JOUR 
AU  - Hashimoto, K.
AU  - Otero, M.
AU  - Imagawa, K.
AU  - De Andrés González, Mª Carmen
AU  - Coico, J. M.
AU  - Roach, H. I.
AU  - Oreffo, R. O. C.
AU  - Marcu, K. B.
AU  - Goldring, M. B.
PY  - 2013
SN  - 0021-9258
UR  - http://hdl.handle.net/20.500.11940/3542
AB  - The role of DNA methylation in the regulation of catabolic genes such as MMP13 and IL1B, which have sparse CpG islands, is poorly understood in the context of musculoskeletal diseases. We report that demethylation of specific CpG sites at -110 bp and...
LA  - eng
KW  - Cartilage
KW  - CpG Islands
KW  - DNA Methylation
KW  - Epigenesis, Genetic
KW  - Gene Expression Profiling
KW  - Gene Expression Regulation, Enzymologic
KW  - Humans
KW  - Interleukin-1beta
KW  - Interleukins
KW  - Matrix Metalloproteinase 13
KW  - Models, Genetic
KW  - Osteoarthritis
KW  - Plasmids
KW  - Point Mutation
KW  - Promoter Regions, Genetic
KW  - Sequence Analysis, DNA
KW  - Transcriptional Activation
TI  - Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites
DO  - 10.1074/jbc.M112.421156
T2  - JOURNAL OF BIOLOGICAL CHEMISTRY
M2  - 10061
VL  - 288
ER  -