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dc.contributor.authorzovoilis, Athanasios
dc.contributor.authorAgbemenyah, Hope Y
dc.contributor.authorAgis Balboa, Roberto Carlos 
dc.contributor.authorStilling, Roman
dc.contributor.authorEdbauer, Dieter
dc.contributor.authorRao, Pooja
dc.contributor.authorFarinelli, Laurent
dc.contributor.authorDelalle, Ivana
dc.contributor.authorSchmitt, Andrea
dc.contributor.authorFalkai, Peter
dc.contributor.authorBahari-Javan, SAnaz
dc.contributor.authorBurkhardt, Susanne
dc.contributor.authorSananbenesi, Farahnaz
dc.contributor.authorFischer, Andre
dc.date.accessioned2019-05-16T09:54:16Z
dc.date.available2019-05-16T09:54:16Z
dc.date.issued2011
dc.identifier.issn0261-4189
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed?term=%22The+EMBO+journal%22%5BJour%5D+AND+4299%5Bpage%5D+AND+2011%5Bpdat%5D&cmd=detailssearches
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199394/es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/12101
dc.description.abstractMicroRNAs are key regulators of transcriptome plasticity and have been implicated with the pathogenesis of brain diseases. Here, we employed massive parallel sequencing and provide, at an unprecedented depth, the complete and quantitative miRNAome of the mouse hippocampus, the prime target of neurodegenerative diseases such as Alzheimer's disease (AD). Using integrative genetics, we identify miR-34c as a negative constraint of memory consolidation and show that miR-34c levels are elevated in the hippocampus of AD patients and corresponding mouse models. In line with this, targeting miR-34 seed rescues learning ability in these mouse models. Our data suggest that miR-34c could be a marker for the onset of cognitive disturbances linked to AD and indicate that targeting miR-34c could be a suitable therapy.es
dc.language.isoenges
dc.subject.meshAlzheimer Disease*
dc.subject.meshMice, Inbred C57BL*
dc.subject.meshMicroRNAs*
dc.subject.meshMemory Disorders*
dc.subject.meshHippocampus*
dc.subject.meshTranscriptome*
dc.titlemicroRNA-34c is a novel target to treat dementiases
dc.typeArtigoes
dc.identifier.doi10.1038/emboj.2011.327
dc.identifier.pmid21946562
dc.issue.number20es
dc.journal.titleThe EMBO Journales
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica Ourense-Pontevedra-Vigo (IBI)es
dc.page.initial4299es
dc.page.final4308es
dc.relation.publisherversionhttp://emboj.embopress.org/content/30/20/4299es
dc.rights.accessRightsembargoedAccesses
dc.subject.decstrastornos de la memoria*
dc.subject.decsratones consanguíneos C57BL*
dc.subject.decsmicroARN*
dc.subject.decshipocampo*
dc.subject.decstranscriptoma*
dc.subject.decsenfermedad de Alzheimer*
dc.subject.keywordenfermedades cognitivases
dc.typefidesArtigo Científico (inclue Orixinal, Orixinal breve, Revisión Sistemática e Meta-análisis)es
dc.typesophosArtículo Originales
dc.volume.number30es


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