Mostrar el registro sencillo del ítem

dc.contributor.authorDe Andrés González, Mª Carmen
dc.contributor.authorMeiss, Mia S
dc.contributor.authorSánchez-Hidalgo, Marina
dc.contributor.authorGonzález-Benjumea, Alejandro
dc.contributor.authorFernández-Bolaños, Jose G
dc.contributor.authorAlarcón-de-la-Lastra, Catalina
dc.contributor.authorOreffo, Richard Oc
dc.date.accessioned2022-03-08T08:49:16Z
dc.date.available2022-03-08T08:49:16Z
dc.date.issued2020
dc.identifier.issn2041-7314
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/32523668es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16192
dc.description.abstractRecent studies have shown that dietary patterns confer protection from certain chronic diseases related to oxidative stress, the immune system and chronic low-grade inflammatory diseases. The aim of this study was to evaluate the anti-inflammatory potential and the capacity to attenuate cartilage degradation using extra-virgin olive oil-derived polyphenols for the treatment of osteoarthritis. Results show that both nutraceuticals ligstroside aglycone and acetylated ligstroside aglycone showed an anti-inflammatory profile. Acetylated ligstroside aglycone significantly reduced the expression of pro-inflammatory genes including NOS2 and MMP13 at both RNA and protein levels; decreased nitric oxide release; and, importantly, reduced proteoglycan loss in human osteoarthritis cartilage explants. Our study demonstrated that a new synthetic acetylated ligstroside aglycone derivative offers enhanced anti-inflammatory profile than the natural nutraceutical compound in osteoarthritis. These results substantiate the role of nutraceuticals in osteoarthritis with implications for therapeutic intervention and our understanding of osteoarthritis pathophysiology.en
dc.rightsAtribución-NoComercial 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.titleOsteoarthritis treatment with a novel nutraceutical acetylated ligstroside aglycone, a chemically modified extra-virgin olive oil polyphenolen
dc.typeJournal Articlees
dc.authorsophosde Andrés, María C;Meiss, Mia S;Sánchez-Hidalgo, Marina;González-Benjumea, Alejandro;Fernández-Bolaños, Jose G;Alarcón-de-la-Lastra, Catalina;Oreffo, Richard Oc
dc.identifier.doi10.1177/2041731420922701
dc.identifier.pmid32523668
dc.identifier.sophos35772
dc.journal.titleJournal of tissue engineeringes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC)es
dc.relation.publisherversionhttps://journals.sagepub.com/doi/pdf/10.1177/2041731420922701es
dc.rights.accessRightsopenAccess
dc.subject.keywordINIBICes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number11.es


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución-NoComercial 4.0 Internacional
Excepto si se señala otra cosa, la licencia del ítem se describe como Atribución-NoComercial 4.0 Internacional