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Osteoarthritis treatment with a novel nutraceutical acetylated ligstroside aglycone, a chemically modified extra-virgin olive oil polyphenol
dc.contributor.author | De Andrés González, Mª Carmen | |
dc.contributor.author | Meiss, Mia S | |
dc.contributor.author | Sánchez-Hidalgo, Marina | |
dc.contributor.author | González-Benjumea, Alejandro | |
dc.contributor.author | Fernández-Bolaños, Jose G | |
dc.contributor.author | Alarcón-de-la-Lastra, Catalina | |
dc.contributor.author | Oreffo, Richard Oc | |
dc.date.accessioned | 2022-03-08T08:49:16Z | |
dc.date.available | 2022-03-08T08:49:16Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2041-7314 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/32523668 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16192 | |
dc.description.abstract | Recent studies have shown that dietary patterns confer protection from certain chronic diseases related to oxidative stress, the immune system and chronic low-grade inflammatory diseases. The aim of this study was to evaluate the anti-inflammatory potential and the capacity to attenuate cartilage degradation using extra-virgin olive oil-derived polyphenols for the treatment of osteoarthritis. Results show that both nutraceuticals ligstroside aglycone and acetylated ligstroside aglycone showed an anti-inflammatory profile. Acetylated ligstroside aglycone significantly reduced the expression of pro-inflammatory genes including NOS2 and MMP13 at both RNA and protein levels; decreased nitric oxide release; and, importantly, reduced proteoglycan loss in human osteoarthritis cartilage explants. Our study demonstrated that a new synthetic acetylated ligstroside aglycone derivative offers enhanced anti-inflammatory profile than the natural nutraceutical compound in osteoarthritis. These results substantiate the role of nutraceuticals in osteoarthritis with implications for therapeutic intervention and our understanding of osteoarthritis pathophysiology. | en |
dc.rights | Atribución-NoComercial 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Osteoarthritis treatment with a novel nutraceutical acetylated ligstroside aglycone, a chemically modified extra-virgin olive oil polyphenol | en |
dc.type | Journal Article | es |
dc.authorsophos | de Andrés, María C;Meiss, Mia S;Sánchez-Hidalgo, Marina;González-Benjumea, Alejandro;Fernández-Bolaños, Jose G;Alarcón-de-la-Lastra, Catalina;Oreffo, Richard Oc | |
dc.identifier.doi | 10.1177/2041731420922701 | |
dc.identifier.pmid | 32523668 | |
dc.identifier.sophos | 35772 | |
dc.journal.title | Journal of tissue engineering | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC) | es |
dc.relation.publisherversion | https://journals.sagepub.com/doi/pdf/10.1177/2041731420922701 | es |
dc.rights.accessRights | openAccess | |
dc.subject.keyword | INIBIC | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 11. | es |