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dc.contributor.authorOlmos, C.
dc.contributor.authorVilacosta, I.
dc.contributor.authorLópez, J.
dc.contributor.authorSáez, C.
dc.contributor.authorAnguita, M.
dc.contributor.authorGarcía-Granja, P. E.
dc.contributor.authorSarriá, C.
dc.contributor.authorSilva, J.
dc.contributor.authorÁlvarez Álvarez, Belén 
dc.contributor.authorMartínez Monzonís, Maria Amparo 
dc.contributor.authorCastillo, J. C.
dc.contributor.authorSeijas, J.
dc.contributor.authorLópez-Picado, A.
dc.contributor.authorPeral, V.
dc.contributor.authorMaroto, L.
dc.contributor.authorSan Román, J. A.
dc.date.accessioned2022-04-26T07:44:05Z
dc.date.available2022-04-26T07:44:05Z
dc.date.issued2020
dc.identifier.issn1471-2334
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/32546269es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16542
dc.description.abstractBACKGROUND: Most serious complications of infective endocarditis (IE) appear in the so-called "critical phase" of the disease, which represents the first days after diagnosis. The majority of patients overcoming the acute phase has a favorable outcome, yet they remain hospitalized for a long period of time mainly to complete antibiotic therapy. The major hypothesis of this trial is that in patients with clinically stable IE and adequate response to antibiotic treatment, without signs of persistent infection, periannular complications or metastatic foci, a shorter antibiotic time period would be as efficient and safe as the classic 4 to 6 weeks antibiotic regimen. METHODS: Multicenter, prospective, randomized, controlled open-label, phase IV clinical trial with a non-inferiority design to evaluate the efficacy of a short course (2 weeks) of parenteral antibiotic therapy compared with conventional antibiotic therapy (4-6 weeks). SAMPLE: patients with IE caused by gram-positive cocci, having received at least 10 days of conventional antibiotic treatment, and at least 7 days after surgery when indicated, without clinical, analytical, microbiological or echocardiographic signs of persistent infection. Estimated sample size: 298 patients. INTERVENTION: Control group: standard duration antibiotic therapy, (4 to 6 weeks) according to ESC guidelines recommendations. Experimental group: short-course antibiotic therapy for 2 weeks. The incidence of the primary composite endpoint of all-cause mortality, unplanned cardiac surgery, symptomatic embolisms and relapses within 6 months after the inclusion in the study will be prospectively registered and compared. CONCLUSIONS: SATIE will investigate whether a two weeks short-course of intravenous antibiotics in patients with IE caused by gram-positive cocci, without signs of persistent infection, is not inferior in safety and efficacy to conventional antibiotic treatment (4-6 weeks). TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04222257 (January 7, 2020). EudraCT 2019-003358-10.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshGram-Positive Cocci*
dc.subject.meshAdult*
dc.subject.meshEndocarditis*
dc.subject.meshMiddle Aged*
dc.subject.meshAdolescent*
dc.subject.meshFollow-Up Studies*
dc.subject.meshAnti-Bacterial Agents*
dc.subject.meshGram-Positive Bacterial Infections*
dc.subject.meshClinical Protocols*
dc.subject.meshHumans*
dc.subject.meshTreatment Outcome*
dc.subject.meshYoung Adult*
dc.subject.meshTime Factors*
dc.subject.meshProspective Studies*
dc.subject.meshAged*
dc.titleShort-course antibiotic regimen compared to conventional antibiotic treatment for gram-positive cocci infective endocarditis: randomized clinical trial (SATIE)en
dc.typeJournal Articlees
dc.authorsophosOlmos, C.;Vilacosta, I.;López, J.;Sáez, C.;Anguita, M.;García-Granja, P. E.;Sarriá, C.;Silva, J.;Álvarez-Álvarez, B.;Martínez-Monzonis, M. A.;Castillo, J. C.;Seijas, J.;López-Picado, A.;Peral, V.;Maroto, L.;San Román, J. A.
dc.identifier.doi10.1186/s12879-020-05132-1
dc.identifier.pmid32546269
dc.identifier.sophos39265
dc.issue.number1es
dc.journal.titleBMC INFECTIOUS DISEASESes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Cardioloxíaes
dc.page.initial417es
dc.rights.accessRightsopenAccess
dc.subject.decsresultado del tratamiento*
dc.subject.decsinfecciones por bacterias grampositivas*
dc.subject.decsendocarditis*
dc.subject.decsestudios de seguimiento*
dc.subject.decsestudios prospectivos*
dc.subject.decsmediana edad*
dc.subject.decsadulto*
dc.subject.decsantibacterianos*
dc.subject.decsanciano*
dc.subject.decsprotocolos clínicos*
dc.subject.decsadulto joven*
dc.subject.decshumanos*
dc.subject.decsfactores de tiempo*
dc.subject.decscocos grampositivos*
dc.subject.decsadolescente*
dc.subject.keywordCHUSes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number20es


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Atribución 4.0 Internacional
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