Association of single nucleotide polymorphisms with renal cell carcinoma in Algerian population

Abstract

Background: Renal cell carcinoma (RCC) is a common malignant tumor of the urinary system. The etiology of RCC is a complex interaction between environmental and multigenetic factors. Genome-wide association studies have iden‑ tifed new susceptibility risk loci for RCC. We examined associations of genetic variants of genes that are involved in metabolism, DNA repair and oncogenes with renal cancer risk. A total of 14 single nucleotide polymorphisms (SNPs) in 11 genes (VEGF, VHL, ATM, FAF1, LRRIQ4, RHOBTB2, OBFC1, DPF3, ALDH9A1 and EPAS1) were examined. Methods: The current case–control study included 87 RCC patients and 114 controls matched for age, gender and ethnic origin. The 14 tag-SNPs were genotyped by Sequenom MassARRAY® iPLEX using blood genomic DNA. Results: Genotype CG and allele G of ATM rs1800057 were signifcantly associated with RCC susceptibility (p=0.043; OR=8.47; CI=1.00–71.76). Meanwhile, we found that genotype AA of rs67311347 polymorphism could increase the risk of RCC (p=0.03; OR=2.95; IC=1.10–7.89). While, genotype TT and T allele of ALDH9A1 rs3845536 were observed to approach signifcance for a protective role against RCC (p=0.007; OR=0.26; CI=0.09–0.70). Conclusion: Our results indicate that ATM rs1800057 may have an efect on the risk of RCC, and suggest that ALDH9A1 was a protective factor against RCC in Algerian population