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Inherited Follicular Epithelial-Derived Thyroid Carcinomas: From Molecular Biology to Histological Correlates
dc.contributor.author | Cameselle Teijeiro, Jose Manuel | |
dc.contributor.author | Mete, O. | |
dc.contributor.author | Asa, S. L. | |
dc.contributor.author | LiVolsi, V. | |
dc.date.accessioned | 2024-01-02T10:02:12Z | |
dc.date.available | 2024-01-02T10:02:12Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1046-3976 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/33495912 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/18434 | |
dc.description.abstract | Cancer derived from thyroid follicular epithelial cells is common; it represents the most common endocrine malignancy. The molecular features of sporadic tumors have been clarified in the past decade. However the incidence of familial disease has not been emphasized and is often overlooked in routine practice. A careful clinical documentation of family history or familial syndromes that can be associated with thyroid disease can help identify germline susceptibility-driven thyroid neoplasia. In this review, we summarize a large body of information about both syndromic and non-syndromic familial thyroid carcinomas. A significant number of patients with inherited non-medullary thyroid carcinomas manifest disease that appears to be sporadic disease even in some syndromic cases. The cytomorphology of the tumor(s), molecular immunohistochemistry, the findings in the non-tumorous thyroid parenchyma and other associated lesions may provide insight into the underlying syndromic disorder. However, the increasing evidence of familial predisposition to non-syndromic thyroid cancers is raising questions about the importance of genetics and epigenetics. What appears to be "sporadic" is becoming less often truly so and more often an opportunity to identify and understand novel genetic variants that underlie tumorigenesis. Pathologists must be aware of the unusual morphologic features that should prompt germline screening. Therefore, recognition of harbingers of specific germline susceptibility syndromes can assist in providing information to facilitate early detection to prevent aggressive disease. | |
dc.language.iso | en | |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Inherited Follicular Epithelial-Derived Thyroid Carcinomas: From Molecular Biology to Histological Correlates | |
dc.type | Journal Article | es |
dc.authorsophos | Cameselle-Teijeiro, J. M.;Mete, O.;Asa, S. L.;LiVolsi, V. | |
dc.identifier.doi | 10.1007/s12022-020-09661-y | |
dc.identifier.pmid | 33495912 | |
dc.identifier.sophos | 43824 | |
dc.issue.number | 1 | |
dc.journal.title | ENDOCRINE PATHOLOGY | |
dc.organization | Servizo Galego de Saúde::Áreas Sanitarias (A.S.)::Área Sanitaria de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Anatomía Patolóxica | |
dc.organization | Servizo Galego de Saúde::Áreas Sanitarias (A.S.)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) | |
dc.page.initial | 77 | |
dc.page.final | 101 | |
dc.rights.accessRights | openAccess | |
dc.subject.keyword | CHUS | es |
dc.subject.keyword | IDIS | es |
dc.typefides | Artículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis) | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 32 |