TY - JOUR 
A1 - Anido Herranz, Urbano
AU - Fernández Nuñez, Natalia
AU - Afonso-Afonso, J.
AU - Santome-Couto, L.
AU - Medina-Colmenero, A.
AU - Fernandez-Calvo, O.
AU - Lazaro-Quintela, M.
AU - Vázquez Estévez, Sergio
T1 - Chemotherapy management for unfit patients with metastatic castration-resistant prostate cancer
Y1 - 2019
SN - 1699-048X
UR - http://hdl.handle.net/20.500.11940/16076
AB - Administration of chemotherapy in prostate cancer depends on patient fitness. In unfit patients, physiological impairment determines the optimum treatment. Although no consensus on assessing patient fitness currently exists, this article proposes an algorithm combining the available information for administering chemotherapy, and in particular docetaxel, in unfit patients. It was constructed by reviewing factors that can influence treatment, such as performance status, taxane-related comorbidities and nutritional status. Geriatric scales for prostate cancer patients and alternative treatment regimens for this population are also reviewed. In summary, patients require overall assessment to optimise treatment. Use of docetaxel should be restricted in unfit patients, and other options must be evaluated, because of high toxicity and low efficacy.
KW - Humans
KW - Karnofsky Performance Status
KW - Prostatic Neoplasms
KW - Physical Fitness
KW - Aged
KW - Antineoplastic Combined Chemotherapy Protocols
KW - Algorithms
KW - protocolos de quimioterapia antineoplásica combinada
KW - anciano
KW - neoplasias de la próstata
KW - algoritmos
KW - aptitud física
KW - grado de actividad de Karnofsky
KW - humanos
KW - Aged
KW - Aged, 80 and over
KW - Algorithms
KW - Antineoplastic Combined Chemotherapy Protocols
KW - Comorbidity
KW - Frailty
KW - Humans
KW - Karnofsky Performance Status
KW - Male
KW - Physical Fitness
KW - Prostatic Neoplasms, Castration-Resistant
KW - Alternative treatment
KW - Performance status
KW - Unfit patient
KW - CHUS
KW - HULA
LA - eng
ER -