TY - GEN AU - Valin, Alvaro AU - Del Rey, Manuel J AU - Municio, Cristina AU - Usategui, Alicia AU - Romero, Marina AU - Fernández-Felipe, Jesús AU - Cañete, Juan D AU - BLANCO GARCIA, FRANCISCO JAVIER AU - Ruano, Yolanda AU - Criado, Gabriel AU - Pablos, José L PY - 2020 SN - 2661-8850 UR - http://hdl.handle.net/20.500.11940/16251 AB - INTRODUCTION: The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts (SF) as a direct cellular target to... KW - Cytokines KW - Interleukin-8 KW - Chemokines KW - STAT Transcription Factors KW - Synovial Membrane KW - Signal Transduction KW - Arthritis KW - Interleukin-6 KW - Cycloheximide KW - Tumor Necrosis Factor-alpha KW - Pyrimidines KW - Chemokine CCL8 KW - Dactinomycin KW - Cell Line KW - Humans KW - Pyrazoles KW - Fibroblasts KW - Cell Movement KW - Kinetics KW - Janus Kinases KW - Gene Expression Regulation KW - Matrix Metalloproteinases KW - Nitriles KW - Inflammation TI - IL6/sIL6R regulates TNF?-inflammatory response in synovial fibroblasts through modulation of transcriptional and post-transcriptional mechanisms DO - 10.1186/s12860-020-00317-7 KW - INIBIC VL - 21 ER -