TY  - JOUR 
AU  - Vinagre, J.
AU  - Almeida, A.
AU  - Pópulo, H.
AU  - Batista, R.
AU  - Lyra, J.
AU  - Pinto, V.
AU  - Coelho, R.
AU  - Celestino, R.
AU  - Prazeres, H.
AU  - Lima, L.
AU  - Melo, M.
AU  - Rocha, A. G. D.
AU  - Preto, A.
AU  - Castro, P.
AU  - Castro, L.
AU  - Pardal, F.
AU  - Lopes, J. M.
AU  - Santos, L. L.
AU  - Reis, R. M.
AU  - Cameselle Teijeiro, Jose Manuel
AU  - Sobrinho-Simões, M.
AU  - Lima, J.
AU  - Máximo, V.
AU  - Soares, P.
PY  - 2013
SN  - 2041-1723
UR  - http://hdl.handle.net/20.500.11940/3781
AB  - Reactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system...
LA  - eng
KW  - Adolescent
KW  - Adult
KW  - Age Factors
KW  - Aged
KW  - Aged, 80 and over
KW  - Cell Line, Tumor
KW  - Cell Transformation, Neoplastic
KW  - Child
KW  - Female
KW  - Gene Expression Regulation, Neoplastic
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Mutation Rate
KW  - Neoplasms
KW  - Promoter Regions, Genetic
KW  - Telomerase
TI  - Frequency of TERT promoter mutations in human cancers
DO  - 10.1038/ncomms3185
T2  - Nature Communications
VL  - 4
ER  -