TY - JOUR AU - Valladares Ayerbes, Manuel AU - Blanco Calvo, Moisés AU - Antón Aparicio, Luis Miguel AU - Figueroa Conde-Valvís, Angélica AU - Figueroa Conde-Valvís, Angélica PY - 2012 SN - 0167-7659 UR - http://hdl.handle.net/20.500.11940/7430 AB - In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues, and attach to a second site. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational downregulation of... LA - eng TI - Biological influence of Hakai in cancer: a 10-year review DO - 10.1007/s10555-012-9348-x T2 - CANCER AND METASTASIS REVIEWS VL - 31 ER -