Growth Hormone (GH) and Cardiovascular System
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Identificadores
URI: http://hdl.handle.net/20.500.11940/11285
PMID: 29346331
DOI: 10.3390/ijms19010290
ESSN: 1422-0067
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Fecha de publicación
2018-01-18Título de revista
International journal of molecular sciences
Tipo de contenido
Artigo
DeCS
glucuronidasa | factor I de crecimiento insulinoide | factores de crecimiento endotelial | enfermedades cardiovasculares | aterosclerosis | estrés oxidativo | hormona del crecimientoMeSH
Atherosclerosis | Glucuronidase | Insulin-Like Growth Factor I | Growth Hormone | Cardiovascular Diseases | Oxidative Stress | Endothelial Growth FactorsResumen
This review describes the positive effects of growth hormone (GH) on the cardiovascular system. We analyze why the vascular endothelium is a real internal secretion gland, whose inflammation is the first step for developing atherosclerosis, as well as the mechanisms by which GH acts on vessels improving oxidative stress imbalance and endothelial dysfunction. We also report how GH acts on coronary arterial disease and heart failure, and on peripheral arterial disease, inducing a neovascularization process that finally increases flow in ischemic tissues. We include some preliminary data from a trial in which GH or placebo is given to elderly people suffering from critical limb ischemia, showing some of the benefits of the hormone on plasma markers of inflammation, and the safety of GH administration during short periods of time, even in diabetic patients. We also analyze how Klotho is strongly related to GH, inducing, after being released from the damaged vascular endothelium, the pituitary secretion of GH, most likely to repair the injury in the ischemic tissues. We also show how GH can help during wound healing by increasing the blood flow and some neurotrophic and growth factors. In summary, we postulate that short-term GH administration could be useful to treat cardiovascular diseases.
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