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Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals
dc.contributor.author | Couselo Carreira, Marcos | |
dc.contributor.author | González Izquierdo, Andrea | |
dc.contributor.author | Amil Diz, María | |
dc.contributor.author | Carreira, Marcos C. | |
dc.contributor.author | Izquierdo, Andrea G. | |
dc.contributor.author | Amil, Maria | |
dc.contributor.author | Casanueva Freijo, Felipe | |
dc.contributor.author | Crujeiras Martínez, Ana Belén | |
dc.date.accessioned | 2019-02-06T07:34:50Z | |
dc.date.available | 2019-02-06T07:34:50Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1942-0900 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/30671172 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/11662 | |
dc.description.abstract | Sirt6 is a member of the sirtuin family involved in physiological and pathological processes including aging, cancer, obesity, diabetes, and energy metabolism. This study is aimed at evaluating the relationship between liver SIRT6 gene expression and the oxidative stress network depending on adiposity levels in Zucker rats, an animal model of metabolic syndrome. We observed that liver-specific SIRT6 expression is reduced in an in vivo model of spontaneous obesity and metabolic syndrome. We also observed that SIRT6 expression in the liver is positively associated with SIRT1 and GST-M2 expressions, two proteins involved in antioxidant protection pathways and inversely related to body weight and plasmatic oxidative status. Interestingly, the SIRT6 expression is upregulated after energy restriction-induced weight loss concomitantly with an improvement in oxidative stress markers. These results suggest that SIRT6 may be a potential therapeutic target for the treatment of obesity and associated metabolic disorders, such as liver disease. | es |
dc.description.sponsorship | Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERobn) | es |
dc.description.sponsorship | Instituto de Salud Carlos III | es |
dc.description.sponsorship | European Regional Development Fund (FEDER) | es |
dc.language.iso | eng | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Aging | * |
dc.subject.mesh | Obesity | * |
dc.subject.mesh | Adiposity | * |
dc.subject.mesh | Oxidative Stress | * |
dc.title | Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals | es |
dc.type | Artigo | es |
dc.rights.holder | Los autores | es |
dc.identifier.doi | 10.1155/2018/6256052 | |
dc.identifier.essn | 1942-0994 | |
dc.identifier.pmid | 30671172 | |
dc.journal.title | Oxidative Medicine and Cellular Longevity | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela | es |
dc.page.initial | 6256052 | es |
dc.relation.projectID | Instituto de Salud Carlos III/PI17/01287 | es |
dc.relation.projectID | Instituto de Salud Carlos III/Miguel Servet/CP17/ 00088 | es |
dc.relation.publisherversion | https://www.hindawi.com/journals/omcl/2018/6256052/ | es |
dc.rights.accessRights | openAccess | es |
dc.subject.decs | adiposidad | * |
dc.subject.decs | obesidad | * |
dc.subject.decs | estrés oxidativo | * |
dc.subject.decs | envejecimiento | * |
dc.subject.keyword | Obesidade | es |
dc.typefides | Artigo Científico (inclue Orixinal, Orixinal breve, Revisión Sistemática e Meta-análisis) | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 2018 | es |
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