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dc.contributor.authorAgis Balboa, Roberto Carlos 
dc.contributor.authorPinheiro, Paulo
dc.contributor.authorRebola, Nelson
dc.contributor.authorKerimoglu, Cemil
dc.contributor.authorBenito, Eva
dc.contributor.authorGertig, Michael
dc.contributor.authorBahari-Javan, SAnaz
dc.contributor.authorJain, Gaurav
dc.contributor.authorBurkhardt, Susanne
dc.contributor.authorDelalle, Ivana
dc.contributor.authorJatzko, Alexander
dc.contributor.authorDettenhofer, Markus
dc.contributor.authorZunszain, Patricia A
dc.contributor.authorSchmitt, Andrea
dc.contributor.authorFalkai, Peter
dc.contributor.authorPape, Julius C
dc.contributor.authorBinder, Elisabeth B
dc.contributor.authorMulle, Christophe
dc.contributor.authorFischer, Andre
dc.contributor.authorSananbenesi, Farahnaz
dc.date.accessioned2019-05-14T12:49:50Z
dc.date.available2019-05-14T12:49:50Z
dc.date.issued2017
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed?term=%22The+EMBO+journal%22%5BJour%5D+AND+2017%5Bpdat%5D+AND+Agis+Balboa+RC%5Bauthor%5D&cmd=detailssearches
dc.identifier.otherPMC5623844es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/12063
dc.description.abstractAge-associated memory decline is due to variable combinations of genetic and environmental risk factors. How these risk factors interact to drive disease onset is currently unknown. Here we begin to elucidate the mechanisms by which post-traumatic stress disorder (PTSD) at a young age contributes to an increased risk to develop dementia at old age. We show that the actin nucleator Formin 2 (Fmn2) is deregulated in PTSD and in Alzheimer's disease (AD) patients. Young mice lacking the Fmn2 gene exhibit PTSD-like phenotypes and corresponding impairments of synaptic plasticity, while the consolidation of new memories is unaffected. However, Fmn2 mutant mice develop accelerated age-associated memory decline that is further increased in the presence of additional risk factors and is mechanistically linked to a loss of transcriptional homeostasis. In conclusion, our data present a new approach to explore the connection between AD risk factors across life span and provide mechanistic insight to the processes by which neuropsychiatric diseases at a young age affect the risk for developing dementia.es
dc.description.sponsorshipBeca Ramón y Cajales
dc.description.sponsorshipGAIN- Agencia Gallega de Innovaciónes
dc.language.isoenges
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshFear*
dc.subject.meshAdult*
dc.subject.meshAging*
dc.subject.meshDementia*
dc.subject.meshMemory*
dc.titleFormin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementiaes
dc.typeArtigoes
dc.identifier.doi10.15252/embj.201796821
dc.identifier.pmid28768717
dc.issue.number19es
dc.journal.titleEmbo Journales
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica Ourense-Pontevedra-Vigo (IBI)es
dc.page.initial2815es
dc.page.final2828es
dc.relation.projectIDRYC-2014-15246es
dc.relation.projectIDIN607D-2016/003es
dc.rights.accessRightsopenAccesses
dc.subject.decsmemoria*
dc.subject.decsmiedo*
dc.subject.decsenvejecimiento*
dc.subject.decsadulto*
dc.subject.decsdemencia*
dc.subject.keywordalzheimeres
dc.subject.keywordestres postraumaticoes
dc.subject.keywordHDAC inhibidores
dc.typefidesArtigo Científico (inclue Orixinal, Orixinal breve, Revisión Sistemática e Meta-análisis)es
dc.typesophosArtículo Originales
dc.volume.number36es


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Atribución 4.0 Internacional
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