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dc.contributor.authorRuibal Morell, Alvaro 
dc.contributor.authorAguiar Fernández, Pablo
dc.contributor.authorDel Río Garma, María del Carmen 
dc.contributor.authorArias, José Ignacio
dc.contributor.authorMenéndez-Rodríguez, Primitiva
dc.contributor.authorGude Sampedro, Francisco 
dc.contributor.authorHerranz Carnero, Michel 
dc.date.accessioned2017-06-07T06:52:37Z
dc.date.available2017-06-07T06:52:37Z
dc.date.issued2015
dc.identifier.issn0250-7005
dc.identifier.urihttp://hdl.handle.net/20.500.11940/133
dc.description.abstractAIM: To study the clinical and biological (cellular proliferation and hormone-dependence) associations during the progression of histological grade (HG), from HG1 to HG3, in invasive ductal carcinomas of the breast (IDC) <1 cm. PATIENTS AND METHODS: The study group included 119 women with IDCs ≤1 cm, aged between 27 and 88 years (median=61 years). The parameters analyzed were: histological grade (HG1: 52; HG2: 45; HG3: 22); axillary lymph node involvement (N); distant metastasis (M); and immunohistochemical expression of estrogen (ER), progesterone (PR) and androgen (AR) receptors, and Ki67, p53 and B-cell lymphoma 2 (BCL2). RESULTS: Compared to HG3 tumors, HG1s exhibited an increased expression of ER, AR and BCL2, as well as lower expression of p53 and Ki67. In HG1 tumors, significant (p<0.05) associations were found between ER and PR (positive), ER and p53 (negative), ER and Ki67 (negative), PR and AR (positive), PR and p53 (negative), AR and p53 (negative), p53 and BCL2 (negative), and between BCL2 and Ki67 (negative). HG3s only showed significant (p<0.05) associations between ER and Ki-67 (negative) and between BCL2 or Ki-67 (negative). Only two significant relationships (ER-Ki67 and BCL2-Ki67) persisted in all three grades. CONCLUSION: Our results lead us to the following conclusions: i) compared HG1, HG3 ductal carcinomas exhibited decreased expression of ER, AR and BCL2 and increased expression of p53 and Ki67; and ii) only two significant and negative relations (ER-Ki67 and BCL2-Ki67) persisted in all three grades.
dc.language.isoeng
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshandrogen receptor
dc.subject.meshBCL2
dc.subject.meshBreast Neoplasms
dc.subject.meshBreast tumors
dc.subject.meshCarcinoma, Ductal, Breast
dc.subject.meshDisease Progression
dc.subject.meshestrogen receptor
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshKi67
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasm Grading
dc.subject.meshTumor Burden
dc.titleHistological grade (HG) in invasive ductal carcinomas of the breast of less than 1 cm: clinical and biological associations during progression from HG1 to HG3
dc.typeArtigoes
dc.authorsophosRuibal, Álvaro
dc.authorsophosAguiar, Pablo
dc.authorsophosDel Rio, María Carmen
dc.authorsophosArias, José Ignacio
dc.authorsophosMenéndez-Rodríguez, Primitiva
dc.authorsophosGude, Francisco
dc.authorsophosHerranz, Michel
dc.identifier.pmid25550604
dc.identifier.sophos17687
dc.issue.number1
dc.journal.titleANTICANCER RESEARCH
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Ferrol::Xerencia da Área de Ferrol::Análise clínicos
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Medicina nuclear
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Epidemioloxía Clínica
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.page.initial569
dc.page.final573
dc.rights.accessRightsopenAccess
dc.typesophosArtículo Original
dc.volume.number35


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