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dc.contributor.authorSane Schepisi, M.
dc.contributor.authorNavarra, A.
dc.contributor.authorAltet Gomez, M. N.
dc.contributor.authorDudnyk, A.
dc.contributor.authorDyrhol-Riise, A. M.
dc.contributor.authorEsteban, J.
dc.contributor.authorGiorgetti, P. F.
dc.contributor.authorGualano, G.
dc.contributor.authorGuglielmetti, L.
dc.contributor.authorHeyckendorf, J.
dc.contributor.authorKaluzhenina, A.
dc.contributor.authorLange, B.
dc.contributor.authorLange, C.
dc.contributor.authorManika, K.
dc.contributor.authorMiah, J.
dc.contributor.authorNanovic, Z.
dc.contributor.authorPontali, E.
dc.contributor.authorRios Prego, Mónica 
dc.contributor.authorSolovic, I.
dc.contributor.authorTiberi, S.
dc.contributor.authorPalmieri, F.
dc.contributor.authorGirardi, E.
dc.date.accessioned2021-09-29T12:42:31Z
dc.date.available2021-09-29T12:42:31Z
dc.date.issued2019
dc.identifier.issn2328-8957
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/30697572es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15363
dc.description.abstractBackground: The growing burden of diabetes mellitus (DM) is posing a threat to global tuberculosis (TB) control. DM triples the risk of developing TB, modifies the presenting features of pulmonary TB, and worsens TB treatment outcomes. We aimed to analyze the prevalence of DM among TB patients and to describe the characteristics and clinical presentation of TB-DM patients in Europe. Methods: We performed a cross-sectional survey on the prevalence of DM among consecutively diagnosed adult TB patients in 11 European TB referral centers located in France, Germany, Greece, Italy, Russia, Slovakia, Spain, and the United Kingdom over the period 2007-2015. We also selected DM-TB cases and TB only controls with a 1:3 ratio to perform a case-control analysis, including patients selected from the countries mentioned above plus Norway and Ukraine. Results: Among 3143 TB enrolled patients, DM prevalence overall was 10.7% and ranged from 4.4% in Greece to 28.5% in the United Kingdom. Patients' median ages ranged from 36 to 49 years, and all centers had >60% males; the proportion of foreign-born patients varied widely across sites. In the case-control study, DM was independently associated with older age and, among older patients, with being foreign-born. Among patients with pulmonary involvement, cavities on chest imaging were more frequently observed among those with DM. Conclusions: Diabetes mellitus represents a challenge for TB control in Europe, especially in foreign-born and in elderly patients. Specific screening strategies should be evaluated.en
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleBurden and Characteristics of the Comorbidity Tuberculosis-Diabetes in Europe: TBnet Prevalence Survey and Case-Control Studyes
dc.typeArtigoes
dc.authorsophosSane Schepisi, M.
dc.authorsophosNavarra, A.
dc.authorsophosAltet Gomez, M. N.
dc.authorsophosDudnyk, A.
dc.authorsophosDyrhol-Riise, A. M.
dc.authorsophosEsteban, J.
dc.authorsophosGiorgetti, P. F.
dc.authorsophosGualano, G.
dc.authorsophosGuglielmetti, L.
dc.authorsophosHeyckendorf, J.
dc.authorsophosKaluzhenina, A.
dc.authorsophosLange, B.
dc.authorsophosLange, C.
dc.authorsophosManika, K.
dc.authorsophosMiah, J.
dc.authorsophosNanovic, Z.
dc.authorsophosPontali, E.
dc.authorsophosPrego, M. R.
dc.authorsophosSolovic, I.
dc.authorsophosTiberi, S.
dc.authorsophosPalmieri, F.
dc.authorsophosGirardi, E.
dc.identifier.doi10.1093/ofid/ofy337
dc.identifier.pmid30697572
dc.identifier.sophos28852
dc.issue.number1es
dc.journal.titleOpen forum infectious diseaseses
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Pontevedra e O Salnés - Complexo Hospitalario Universitario de Pontevedra::Medicina Interna
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330516/pdf/ofy337.pdf
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUP
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)
dc.typesophosArtículo Original
dc.volume.number6es


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