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Rapid evolution and biogeographic spread in a colorectal cancer

dc.contributor.authorAlves, J. M.
dc.contributor.authorPrado-López, S.
dc.contributor.authorCameselle Teijeiro, Jose Manuel 
dc.contributor.authorPosada, D.
dc.date.accessioned2021-09-29T12:42:41Z
dc.date.available2021-09-29T12:42:41Z
dc.date.issued2019
dc.identifier.issn2041-1723
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31723138es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15368
dc.description.abstractHow and when tumoral clones start spreading to surrounding and distant tissues is currently unclear. Here we leveraged a model-based evolutionary framework to investigate the demographic and biogeographic history of a colorectal cancer. Our analyses strongly support an early monoclonal metastatic colonization, followed by a rapid population expansion at both primary and secondary sites. Moreover, we infer a hematogenous metastatic spread under positive selection, plus the return of some tumoral cells from the liver back to the colon lymph nodes. This study illustrates how sophisticated techniques typical of organismal evolution can provide a detailed, quantitative picture of the complex tumoral dynamics over time and space.en
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshHumans*
dc.subject.meshGenetic Heterogeneity*
dc.subject.meshNeoplasm Metastasis*
dc.subject.meshDisease Progression*
dc.subject.meshColorectal Neoplasms*
dc.titleRapid evolution and biogeographic spread in a colorectal canceres
dc.typeArtigoes
dc.authorsophosAlves, J. M.
dc.authorsophosPrado-López, S.
dc.authorsophosCameselle-Teijeiro, J. M.
dc.authorsophosPosada, D.
dc.identifier.doi10.1038/s41467-019-12926-8
dc.identifier.pmid31723138
dc.identifier.sophos30546
dc.issue.number1es
dc.journal.titleNature Communicationses
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Anatomía Patolóxica
dc.page.initial5139es
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853914/pdf/41467_2019_Article_12926.pdf
dc.rights.accessRightsopenAccess
dc.subject.decsheterogeneidad genética*
dc.subject.decsmetástasis neoplásica*
dc.subject.decshumanos*
dc.subject.decsprogresión de la enfermedad*
dc.subject.decsneoplasias colorrectales*
dc.subject.keywordCHUS
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)
dc.typesophosArtículo Original
dc.volume.number10es


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Nat Commun . 2019 Nov 13;10(1):5139. doi: 10.1038/s41467-019-12926-8

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Atribución 4.0 Internacional
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