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dc.contributor.authorArgibay González, Bárbara
dc.contributor.authorCampos Pérez, Francisco 
dc.contributor.authorPérez Mato, María
dc.contributor.authorVieites Prado, Alba
dc.contributor.authorCorrea Paz, Clara
dc.contributor.authorLópez Arias, Esteban 
dc.contributor.authorDa Silva Candal, Andrés Alexander
dc.contributor.authorMoreno, V.
dc.contributor.authorMontero, C.
dc.contributor.authorSobrino Moreiras, Tomas 
dc.contributor.authorCastillo Sánchez, José 
dc.contributor.authorIglesias Rey, Ramón
dc.date.accessioned2021-09-29T12:42:53Z
dc.date.available2021-09-29T12:42:53Z
dc.date.issued2019
dc.identifier.issn1664-2295
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31507516es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15372
dc.description.abstractPhotobiomodulation (PBM) therapy is a promising therapeutic approach for several pathologies, including stroke. The biological effects of PBM for the treatment of cerebral ischemia have previously been explored as a neuroprotective strategy using different light sources, wavelengths, and incident light powers. However, the capability of PBM as a novel alternative therapy to stimulate the recovery of the injured neuronal tissue after ischemic stroke has been poorly explored. The aim of this study was to investigate the low-level light irradiation therapy by using Light Emitting Diodes (LEDs) as potential therapeutic strategy for stroke. The LED photobiomodulation (continuous wave, 830 nm, 0.2-0.6 J/cm(2)) was firstly evaluated at different energy densities in C17.2 immortalized mouse neural progenitor cell lines, in order to observe if this treatment had any effect on cells, in terms of proliferation and viability. Then, the PBM-LED effect (continuous wave, 830 nm, 0.28 J/cm(2) at brain cortex) on long-term recovery (12 weeks) was analyzed in ischemic animal model by means lesion reduction, behavioral deficits, and functional magnetic resonance imaging (fMRI). Analysis of cellular proliferation after PBM was significantly increased (1 mW) in all different exposure times used; however, this effect could not be replicated in vivo experimental conditions, as PBM did not show an infarct reduction or functional recovery. Despite the promising therapeutic effect described for PBM, further preclinical studies are necessary to optimize the therapeutic window of this novel therapy, in terms of the mechanism associated to neurorecovery and to reduce the risk of failure in futures clinical trials.en
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleLight-Emitting Diode Photobiomodulation After Cerebral Ischemiaes
dc.typeArtigoes
dc.authorsophosArgibay, B.
dc.authorsophosCampos, F.
dc.authorsophosPerez-Mato, M.
dc.authorsophosVieites-Prado, A.
dc.authorsophosCorrea-Paz, C.
dc.authorsophosLópez-Arias, E.
dc.authorsophosDa Silva-Candal, A.
dc.authorsophosMoreno, V.
dc.authorsophosMontero, C.
dc.authorsophosSobrino, T.
dc.authorsophosCastillo, J.
dc.authorsophosIglesias-Rey, R.
dc.identifier.doi10.3389/fneur.2019.00911
dc.identifier.pmid31507516
dc.identifier.sophos30561
dc.issue.number10es
dc.journal.titleFrontiers in neurologyes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Neuroloxía
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
dc.page.initial911es
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713875/pdf/fneur-10-00911.pdf
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUS
dc.subject.keywordIDIS
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)
dc.typesophosArtículo Original
dc.volume.number10es


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Atribución 4.0 Internacional
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