ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents
Barja Fernández, Silvia; Folgueira Cobos, Cintia; Castelao Taboada, Cecilia; Pena León, Verónica; González Sáenz, Patricia Ester; Vázquez Cobela, Rocio; Aguilera, C. M.; Gil-Campos, M.; Bueno, G.; Gil, Á; Moreno, L. A.; Ruiz-Piñon, M.; García Palacios, María; Casanueva Freijo, Felipe; Diéguez González, Carlos; Nogueiras Pozo, Rubén; Leis Trabazo, María Rosaura; Seoane Camino, Luisa Maria
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Identificadores
URI: http://hdl.handle.net/20.500.11940/15376
PMID: 31207920
DOI: 10.3390/nu11061340
ISSN: 2072-6643
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Fecha de publicación
2019Título de revista
Nutrients
Tipo de contenido
Artigo
DeCS
estudios longitudinales | obesidad | humanos | estudios transversales | lípidos | índice de masa corporal | adolescenteMeSH
Longitudinal Studies | Humans | Cross-Sectional Studies | Obesity | Adolescent | Body Mass Index | LipidsResumen
Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and affects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and different lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two different cohorts. In the first cohort (n = 150, age 3-17 years), which included children with normal weight or obesity, we performed a cross-sectional study. In the second cohort, which included only children with obesity (n = 20, age 5-18 years) followed up for two years after an intervention for weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index (HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant association of ANGPTL-4 with pediatric obesity and plasma lipid profile.
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