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Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity

dc.contributor.authorBarrachina, M. N.
dc.contributor.authorIzquierdo, I.
dc.contributor.authorHermida-Nogueira, L.
dc.contributor.authorMartís Sueiro, Aurelio Manuel
dc.contributor.authorGuitián, E.
dc.contributor.authorCasanueva Freijo, Felipe 
dc.contributor.authorFarndale, R. W.
dc.contributor.authorMoroi, M.
dc.contributor.authorJung, S. M.
dc.contributor.authorPardo, M.
dc.contributor.authorGarcía, Á
dc.date.accessioned2021-09-29T12:43:08Z
dc.date.available2021-09-29T12:43:08Z
dc.date.issued2019
dc.identifier.issn2352-3409
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31372431es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15377
dc.description.abstractThis data article is associated with the manuscript "GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity" [1]. The study refers to a combination of different approaches in order to identify platelet-derived biomarkers in obesity. A total of 34 obese patients and their lean-matched controls were included in the study. We carried out a proteomic and functional (aggregation assays) analysis to find alterations in platelet-derived signalling pathways. After that, biochemical and mechanistic (flow cytometry assays) approaches were done in order to confirm a hyperactivation of the GPVI-related signalling pathway.en
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleData on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesityes
dc.typeArtigoes
dc.authorsophosBarrachina, M. N.
dc.authorsophosIzquierdo, I.
dc.authorsophosHermida-Nogueira, L.
dc.authorsophosSueiro, A. M.
dc.authorsophosGuitián, E.
dc.authorsophosCasanueva, F. F.
dc.authorsophosFarndale, R. W.
dc.authorsophosMoroi, M.
dc.authorsophosJung, S. M.
dc.authorsophosPardo, M.
dc.authorsophosGarcía, Á
dc.identifier.doi10.1016/j.dib.2019.103784
dc.identifier.pmid31372431
dc.identifier.sophos30581
dc.issue.number23es
dc.journal.titleData in Briefes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Endocrinoloxía
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
dc.page.initial103784es
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661234/pdf/main.pdf
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUS
dc.subject.keywordIDIS
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)
dc.typesophosArtículo Original
dc.volume.number23es


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Data Brief . 2019 Feb 28;23:103784. doi: 10.1016/j.dib.2019.103784

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Atribución 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución 4.0 Internacional