Self-assembled hyaluronan nanocapsules for the intracellular delivery of anticancer drugs
Identificadores
Identificadores
Fecha de publicación
2019Título de revista
Scientific Reports
Tipo de contenido
Artigo
DeCS
nanocápsulas | humanos | sistemas de liberación de medicamentos | neoplasias pulmonares | ácido hialurónico | antineoplásicosMeSH
Lung Neoplasms | Hyaluronic Acid | Humans | Drug Delivery Systems | Nanocapsules | Antineoplastic AgentsResumen
Preparation of sophisticated delivery systems for nanomedicine applications generally involve multi-step procedures using organic solvents. In this study, we have developed a simple self-assembling process to prepare docetaxel-loaded hyaluronic acid (HA) nanocapsules by using a self-emulsification process without the need of organic solvents, heat or high shear forces. These nanocapsules, which comprise an oily core and a shell consisting of an assembly of surfactants and hydrophobically modified HA, have a mean size of 130 nm, a zeta potential of -20 mV, and exhibit high docetaxel encapsulation efficiency. The nanocapsules exhibited an adequate stability in plasma. Furthermore, in vitro studies performed using A549 lung cancer cells, showed effective intracellular delivery of docetaxel. On the other hand, blank nanocapsules showed very low cytotoxicity. Overall, these results highlight the potential of self-emulsifying HA nanocapsules for intracellular drug delivery.