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dc.contributor.authorCarriazo, S.
dc.contributor.authorPerez-Gomez, M. V.
dc.contributor.authorCordido Eijo, Adrian
dc.contributor.authorGarcía González , Miguel Ángel
dc.contributor.authorSanz, A. B.
dc.contributor.authorOrtiz, A.
dc.contributor.authorSanchez-Niño, M. D.
dc.date.accessioned2021-09-30T09:19:02Z
dc.date.available2021-09-30T09:19:02Z
dc.date.issued2019
dc.identifier.issn2072-6643
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31336917es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15402
dc.description.abstractAutosomal dominant polycystic kidney disease (ADPKD) is the most common genetic nephropathy, and tolvaptan is the only therapy available. However, tolvaptan slows but does not stop disease progression, is marred by polyuria, and most patients worldwide lack access. This and recent preclinical research findings on the glucose-dependency of cyst-lining cells have renewed interest in the dietary management of ADPKD. We now review the current dietary recommendations for ADPKD patients according to clinical guidelines, the evidence base for those, and the potential impact of preclinical studies addressing the impact of diet on ADPKD progression. The clinical efficacy of tolvaptan has put the focus on water intake and solute ingestion as modifiable factors that may impact tolvaptan tolerance and ADPKD progression. By contrast, dietary modifications suggested to ADPKD patients, such as avoiding caffeine, are not well supported and their impact is unknown. Recent studies have identified a chronic shift in energy production from mitochondrial oxidative phosphorylation to aerobic glycolysis (Warburg effect) as a contributor to cyst growth, rendering cyst cells exquisitely sensitive to glucose availability. Therefore, low calorie or ketogenic diets have delayed preclinical ADPKD progression. Additional preclinical data warn of potential negative impact of excess dietary phosphate or oxalate in ADPKD progression.en
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshHumans*
dc.titleDietary Care for ADPKD Patients: Current Status and Future Directionses
dc.typeArtigoes
dc.authorsophosCarriazo, S.
dc.authorsophosPerez-Gomez, M. V.
dc.authorsophosCordido, A.
dc.authorsophosGarcía-González, M. A.
dc.authorsophosSanz, A. B.
dc.authorsophosOrtiz, A.
dc.authorsophosSanchez-Niño, M. D.
dc.identifier.doi10.3390/nu11071576
dc.identifier.pmid31336917
dc.identifier.sophos30612
dc.issue.number7es
dc.journal.titleNutrientses
dc.organizationServizo Galego de Saúde
dc.organizationServizo Galego de Saúde
dc.page.initial1576es
dc.relation.publisherversionhttps://res.mdpi.com/d_attachment/nutrients/nutrients-11-01576/article_deploy/nutrients-11-01576.pdf
dc.rights.accessRightsopenAccess
dc.subject.decshumanos*
dc.subject.keywordCHUS
dc.subject.keywordIDIS
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)
dc.typesophosArtículo de Revisión
dc.volume.number11es


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