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Identification of a 3'-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study
dc.contributor.author | López-Mejías, R. | |
dc.contributor.author | Carmona, F. D. | |
dc.contributor.author | Genre, F. | |
dc.contributor.author | Remuzgo-Martínez, S. | |
dc.contributor.author | González Juanatey, Carlos | |
dc.contributor.author | Corrales, A. | |
dc.contributor.author | Vicente, E. F. | |
dc.contributor.author | Pulito-Cueto, V. | |
dc.contributor.author | Miranda Filloy, José Alberto | |
dc.contributor.author | Ramírez Huaranga, M. A. | |
dc.contributor.author | Blanco, R. | |
dc.contributor.author | Robustillo-Villarino, M. | |
dc.contributor.author | Rodríguez-Carrio, J. | |
dc.contributor.author | Alperi-López, M. | |
dc.contributor.author | Alegre-Sancho, J. J. | |
dc.contributor.author | Mijares, V. | |
dc.contributor.author | Lera-Gómez, L. | |
dc.contributor.author | Pérez Pampín, Eva | |
dc.contributor.author | González, A. | |
dc.contributor.author | Ortega-Castro, R. | |
dc.contributor.author | López-Pedrera, C. | |
dc.contributor.author | García Vivar, M. L. | |
dc.contributor.author | Gómez-Arango, C. | |
dc.contributor.author | Raya, E. | |
dc.contributor.author | Narvaez, J. | |
dc.contributor.author | Balsa, A. | |
dc.contributor.author | López-Longo, F. J. | |
dc.contributor.author | Carreira, P. | |
dc.contributor.author | González-Álvaro, I. | |
dc.contributor.author | Rodríguez-Rodríguez, L. | |
dc.contributor.author | Fernández-Gutiérrez, B. | |
dc.contributor.author | Ferraz-Amaro, I. | |
dc.contributor.author | Gualillo ., Oreste | |
dc.contributor.author | Castañeda, S. | |
dc.contributor.author | Martín, J. | |
dc.contributor.author | Llorca, J. | |
dc.contributor.author | González-Gay, M. A. | |
dc.date.accessioned | 2021-10-14T07:33:13Z | |
dc.date.available | 2021-10-14T07:33:13Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 2326-5191 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/30251476 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590191/pdf/ART-71-351.pdf | |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/15494 | |
dc.description.abstract | OBJECTIVE: To investigate the genetic background influencing the development of cardiovascular (CV) disease in patients with rheumatoid arthritis (RA). METHODS: We performed a genome-wide association study (GWAS) in which, after quality control and imputation, a total of 6,308,944 polymorphisms across the whole genome were analyzed in 2,989 RA patients of European origin. Data on subclinical atherosclerosis, obtained through assessment of carotid intima-media thickness (CIMT) and presence/absence of carotid plaques by carotid ultrasonography, were available for 1,355 individuals. RESULTS: A genetic variant of the RARB gene (rs116199914) was associated with CIMT values at the genome-wide level of significance (minor allele [G] beta coefficient 0.142, P = 1.86 x 10(-8) ). Interestingly, rs116199914 overlapped with regulatory elements in tissues related to CV pathophysiology and immune cells. In addition, biologic pathway enrichment and predictive protein-protein relationship analyses, including suggestive GWAS signals of potential relevance, revealed a functional enrichment of the collagen biosynthesis network related to the presence/absence of carotid plaques (Gene Ontology no. 0032964; false discovery rate-adjusted P = 4.01 x 10(-3) ). Furthermore, our data suggest potential influences of the previously described candidate CV risk loci NFKB1, MSRA, and ZC3HC1 (P = 8.12 x 10(-4) , P = 5.94 x 10(-4) , and P = 2.46 x 10(-4) , respectively). CONCLUSION: The present findings strongly suggest that genetic variation within RARB contributes to the development of subclinical atherosclerosis in patients with RA. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Identification of a 3'-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study | |
dc.type | Artigo | es |
dc.authorsophos | Gualillo ., Oreste | |
dc.authorsophos | González Juanatey, Carlos | |
dc.authorsophos | Miranda Filloy, José Alberto | |
dc.authorsophos | Pérez Pampín, Eva | |
dc.identifier.doi | 10.1002/art.40734 | |
dc.identifier.pmid | 30251476 | |
dc.identifier.sophos | 30840 | |
dc.issue.number | 3 | |
dc.journal.title | Arthritis and Rheumatology | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Reumatoloxía | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Lugo, Cervo e Monforte de lemos - Complexo Hospitalario Universitario Lucus Augusti::Cardioloxía | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Lugo, Cervo e Monforte de lemos - Complexo Hospitalario Universitario Lucus Augusti::Reumatoloxía | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) | |
dc.page.initial | 351 | es |
dc.page.final | 360 | es |
dc.rights.accessRights | openAccess | |
dc.subject.keyword | CHUS | |
dc.subject.keyword | HULA | |
dc.subject.keyword | IDIS | |
dc.typefides | Artículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis) | |
dc.typesophos | Artículo Original | |
dc.volume.number | 71 |
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