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dc.contributor.authorMartin-Cardona, A.
dc.contributor.authorFernandez-Esparrach, G.
dc.contributor.authorSubtil, J. C.
dc.contributor.authorIGLESIAS GARCIA, JULIO 
dc.contributor.authorGarcia-Guix, M.
dc.contributor.authorBarturen Barroso, A.
dc.contributor.authorGimeno-Garcia, A. Z.
dc.contributor.authorEsteban, J. M.
dc.contributor.authorPardo Balteiro, A.
dc.contributor.authorVelasco-Guardado, A.
dc.contributor.authorVazquez-Sequeiros, E.
dc.contributor.authorLoras, C.
dc.contributor.authorMartinez-Moreno, B.
dc.contributor.authorCastellot, A.
dc.contributor.authorHuertas, C.
dc.contributor.authorMartinez-Lapiedra, M.
dc.contributor.authorSanchez-Yague, A.
dc.contributor.authorTeran, A.
dc.contributor.authorMorales-Alvarado, V. J.
dc.contributor.authorBetes, M.
dc.contributor.authorDE LA IGLESIA GARCIA, DANIEL 
dc.contributor.authorSánchez-Montes, C.
dc.contributor.authorLozano, M. D.
dc.contributor.authorLariño Noia, José 
dc.contributor.authorGines, A.
dc.contributor.authorTebe, C.
dc.contributor.authorGornals, J. B.
dc.date.accessioned2021-10-14T07:33:35Z
dc.date.available2021-10-14T07:33:35Z
dc.date.issued2019
dc.identifier.issn1932-6203
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31170163
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553722/pdf/pone.0216658.pdf
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15500
dc.description.abstractBACKGROUND: There are limited data about the role of endoscopic ultrasound-guided tissue acquisition (EUS-TA), by fine needle aspiration (EUS-FNA) or biopsy (EUS-FNB), in the evaluation of the adrenal glands (AG). The primary aim was to assess the diagnostic yield and safety. The secondary aims were the malignancy predictors, and to create a predictive model of malignancy. METHODS: This was a retrospective nationwide study involving all Spanish hospitals experienced in EUS-TA of AGs. Inclusion period was from April-2003 to April-2016. Inclusion criteria: all consecutive cases that underwent EUS-TA of AGs. EUS and cytopathology findings were evaluated. Statistical analyses: diagnostic accuracy of echoendoscopist's suspicion using cytology by EUS-TA, as gold standard; multivariate logistic regression model to predict tumor malignancy. RESULTS: A total of 204 EUS-TA of AGs were evaluated. Primary tumor locations were lung70%, others19%, and unknown11%. AG samples were adequate for cytological diagnosis in 91%, and confirmed malignancy in 60%. Diagnostic accuracy of the endosonographer's suspicion was 68%. The most common technique was: a 22-G (65%) and cytological needle (75%) with suction-syringe (66%). No serious adverse events were described. The variables most associated with malignancy were size>30mm (OR2.27; 95%CI, 1.16-4.05), heterogeneous echo-pattern (OR2.11; 95%CI, 1.1-3.9), variegated AG shape (OR2.46; 95%CI, 1-6.24), and endosonographer suspicion (OR17.46; 95%CI, 6.2-58.5). The best variables for a predictive multivariate logistic model of malignancy were age, sex, echo-pattern, and AG-shape. CONCLUSIONS: EUS-TA of the AGs is a safe, minimally invasive procedure, allowing an excellent diagnostic yield. These results suggest the possibility of developing a pre-EUS procedure predictive malignancy model.
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleEUS-guided tissue acquisition in the study of the adrenal glands: Results of a nationwide multicenter study
dc.typeArtigoes
dc.contributor.authorcorpSpanish Group for EUS-Guided TA in the adrenal gland
dc.authorsophosIglesias García, Julio
dc.authorsophosLariño Noia, José
dc.authorsophosDe La Iglesia García, Daniel
dc.identifier.doi10.1371/journal.pone.0216658
dc.identifier.pmid31170163
dc.identifier.sophos30856
dc.issue.number6
dc.journal.titlePLoS One
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Dixestivo
dc.page.initiale0216658es
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUS
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)
dc.typesophosArtículo Original
dc.volume.number14


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