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CTCs-derived xenograft development in a triple negative breast cancer case
dc.contributor.author | Pereira-Veiga, T. | |
dc.contributor.author | Abreu, M. | |
dc.contributor.author | Robledo, D. | |
dc.contributor.author | Matias-Guiu, X. | |
dc.contributor.author | Santacana, M. | |
dc.contributor.author | Sánchez, L. | |
dc.contributor.author | CUEVAS ALVAREZ, JUAN | |
dc.contributor.author | PALACIOS OZORES, PATRICIA | |
dc.contributor.author | ABDULKADER NALLIB, IHAB | |
dc.contributor.author | López López, Rafael | |
dc.contributor.author | Muinelo Romay , Laura | |
dc.contributor.author | Costa Nogueira, Clotilde | |
dc.date.accessioned | 2021-10-14T09:18:53Z | |
dc.date.available | 2021-10-14T09:18:53Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0020-7136 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/30450632 | |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/15528 | |
dc.description.abstract | Triple-negative breast cancer (TNBC) is characterized by high rates of metastasis and no available molecular targets. CTCs derived xenografts (CDX) have demonstrated to be a promising tool for understanding cancer biology. In our study, a CDX from a TNBC patient was developed for the first time. After CDX characterization, WNT signaling was found as the main mechanism related with this tumor biology and potential CTCs markers were identified and subsequently validated in TNBC patients. In this cohort high levels of MELK expression were associated with poorer survival rates. Overall, our study demonstrates that CTCs from TNBC are tumorigenic and CDXs are a useful model to obtain valuable information about the tumor. | |
dc.title | CTCs-derived xenograft development in a triple negative breast cancer case | |
dc.type | Artigo | es |
dc.authorsophos | Abdulkader Nallib, Ihab | |
dc.authorsophos | Muinelo Romay , Laura | |
dc.authorsophos | López López, Rafael | |
dc.authorsophos | Cuevas Álvarez, Juan | |
dc.authorsophos | Palacios Ozores, Patricia | |
dc.authorsophos | Costa Nogueira, Clotilde | |
dc.identifier.doi | 10.1002/ijc.32001 | |
dc.identifier.pmid | 30450632 | |
dc.identifier.sophos | 30905 | |
dc.issue.number | 9 | |
dc.journal.title | INTERNATIONAL JOURNAL OF CANCER | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Anatomía Patolóxica | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Oncoloxía médica | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) | |
dc.page.initial | 2254 | es |
dc.page.final | 2265 | es |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.32001?download=true | |
dc.subject.keyword | CHUS | |
dc.subject.keyword | IDIS | |
dc.typefides | Artículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis) | |
dc.typesophos | Artículo Original | |
dc.volume.number | 144 |
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