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dc.contributor.authorRapado González, Oscar
dc.contributor.authorMajem, B.
dc.contributor.authorALVAREZ CASTRO, ANA MARIA 
dc.contributor.authorDíaz Peña, Roberto
dc.contributor.authorAbalo Piñeiro, Alicia
dc.contributor.authorSuárez-Cabrera, L.
dc.contributor.authorSantamaría, A.
dc.contributor.authorLópez López, Rafael 
dc.contributor.authorMuinelo Romay , Laura
dc.contributor.authorSuárez Cunqueiro, María Mercedes
dc.date.accessioned2021-10-14T09:19:14Z
dc.date.available2021-10-14T09:19:14Z
dc.date.issued2019
dc.identifier.issn2077-0383
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31757017
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15535
dc.description.abstractSalivary microRNAs (miRNAs) are of high interest as diagnostic biomarkers for non-oral cancer. However, little is known about their value for colorectal cancer (CRC) detection. Our study aims to characterize salivary miRNAs in order to identify non-invasive markers for CRC diagnosis. The screening of 754 miRNAs was performed in saliva samples from 14 CRC and 10 healthy controls. The differential expressed miRNAs were validated by RT-qPCR in 51 CRC, 19 adenomas and 37 healthy controls. Receiver operating characteristic (ROC) curves and logistic regression models were performed to analyze the clinical value of these miRNAs. Twenty-two salivary miRNAs were significantly deregulated in CRC patients vs. healthy individuals (P < 0.05) in the discovery phase. From those, five upregulated miRNAs (miR-186-5p, miR-29a-3p, miR-29c-3p, miR-766-3p, and miR-491-5p) were confirmed to be significantly higher in the CRC vs. healthy group (P < 0.05). This five-miRNA signature showed diagnostic value (72% sensitivity, 66.67% specificity, AUC = 0.754) to detect CRC, which was even higher in combination with carcinoembryonic antigen (CEA) levels. Overall, after the first global characterization of salivary miRNAs in CRC, a five-miRNA panel was identified as a promising tool to diagnose this malignancy, representing a novel approach to detect cancer-associated epigenetic alterations using a non-invasive strategy.
dc.language.isoen
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleA Novel Saliva-Based miRNA Signature for Colorectal Cancer Diagnosis
dc.typeArtigoes
dc.authorsophosRapado González, Oscar
dc.authorsophosMajem, B.
dc.authorsophosAlvarez Castro, Ana Maria
dc.authorsophosDíaz Peña, Roberto
dc.authorsophosAbalo Piñeiro, Alicia
dc.authorsophosSuárez-Cabrera, L.
dc.authorsophosSantamaría, A.
dc.authorsophosLópez López, Rafael
dc.authorsophosMuinelo Romay , Laura
dc.authorsophosSuárez Cunqueiro, María Mercedes
dc.identifier.doi10.3390/jcm8122029
dc.identifier.pmid31757017
dc.identifier.sophos30936
dc.issue.number12
dc.journal.titleJournal of Clinical Medicine
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Dixestivo
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Oncoloxía médica
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
dc.relation.publisherversionhttps://res.mdpi.com/d_attachment/jcm/jcm-08-02029/article_deploy/jcm-08-02029-v2.pdf
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUS
dc.subject.keywordIDIS
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)
dc.typesophosArtículo Original
dc.volume.number8


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