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dc.contributor.authorRodríguez Mañero, Moises 
dc.contributor.authorLópez-Pardo Pardo, Estrella
dc.contributor.authorCordero, A.
dc.contributor.authorRuano Raviña, Alberto
dc.contributor.authorNovo Platas, José
dc.contributor.authorPereira Vázquez, María 
dc.contributor.authorMartínez Gómez, Álvaro 
dc.contributor.authorGarcía Seara, Javier 
dc.contributor.authorMartínez Sande, Jose Luis 
dc.contributor.authorPEÑA GIL, CARLOS 
dc.contributor.authorMazón Ramos, María Pilar 
dc.contributor.authorGarcía Acuña, José María 
dc.contributor.authorValdés Cuadrado, Luis 
dc.contributor.authorGonzález Juanatey, José Ramón 
dc.date.accessioned2021-10-14T09:19:27Z
dc.date.available2021-10-14T09:19:27Z
dc.date.issued2019
dc.identifier.issn1176-9106
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/30863038
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15540
dc.description.abstractBackground: Patients with COPD are at higher risk of presenting with atrial fibrillation (AF). Information about clinical outcomes and optimal medical treatment of AF in the setting of COPD remains missing. We aimed to describe the prevalence of COPD in a sizeable cohort of real-world AF patients belonging to the same healthcare area and to examine the relationship between comorbid COPD and AF prognosis. Methods: Prospective analysis performed in a specific healthcare area. Data were obtained from several sources within the "data warehouse of the Galician Healthcare Service" using multiple analytical tools. Statistical analyses were completed using SPSS 19 and STATA 14.0. Results: A total of 7,990 (2.08%) patients with AF were registered throughout 2013 in our healthcare area (n=348,985). Mean age was 76.83+/-10.51 years and 937 (11.7%) presented with COPD. COPD patients had a higher mean CHA2DS2-VASc (4.21 vs 3.46; P=0.02) and received less beta-blocker and more digoxin therapy than those without COPD. During a mean follow-up of 707+/-103 days, 1,361 patients (17%) died. All-cause mortality was close to two fold higher in the COPD group (28.3% vs 15.5%; P<0.001). Independent predictive factors for all-cause mortality were age, heart failure, diabetes, previous thromboembolic event, dementia, COPD, and oral anticoagulation (OA). There were nonsignificant differences in thromboembolic events (1.7% vs 1.5%; P=0.7), but the rate of hemorrhagic events was significantly higher in the COPD group (3.3% vs 1.9%; P=0.004). Age, valvular AF, OA, and COPD were independent predictive factors for hemorrhagic events. In COPD patients, age, heart failure, vasculopathy, lack of OA, and lack of beta-blocker use were independent predictive factors for all-cause mortality. Conclusion: AF patients with COPD have a higher incidence of adverse events with significantly increased rates of all-cause mortality and hemorrhagic events than AF patients without COPD. However, comorbid COPD was not associated with differences in cardiovascular death or stroke rate. OA and beta-blocker treatment presented a risk reduction in mortality while digoxin use exerted a neutral effect.
dc.rightsAtribución-NoComercial 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.titleA prospective study of the clinical outcomes and prognosis associated with comorbid COPD in the atrial fibrillation population
dc.typeArtigoes
dc.authorsophosGonzález Juanatey, José Ramón
dc.authorsophosGarcía Seara, Javier
dc.authorsophosGarcía Acuña, José María
dc.authorsophosValdés Cuadrado, Luis
dc.authorsophosMartínez Sande, Jose Luis
dc.authorsophosMazón Ramos, María Pilar
dc.authorsophosRuano Raviña, Alberto
dc.authorsophosPereira Vázquez, María
dc.authorsophosPeña Gil, Carlos
dc.authorsophosLópez-Pardo Pardo, Estrella
dc.authorsophosRodríguez Mañero, Moises
dc.authorsophosMartínez Gómez, Álvaro
dc.authorsophosNovo Platas, José
dc.identifier.doi10.2147/COPD.S174443
dc.identifier.pmid30863038
dc.identifier.sophos30956
dc.journal.titleInternational journal of chronic obstructive pulmonary disease
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Cardioloxía
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Neumoloxía
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
dc.page.initial371es
dc.page.final380es
dc.relation.publisherversionhttps://www.dovepress.com/front_end/cr_data/cache/pdf/download_1615286949_604752a5b7edb/copd-174443-a-prospective-study-of-the-clinical-outcomes-and-prognosis-a-021119.pdf
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUS
dc.subject.keywordIDIS
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)
dc.typesophosArtículo Original
dc.volume.number14.


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Atribución-NoComercial 4.0 Internacional
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