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dc.contributor.authorSchepers, E.
dc.contributor.authorLousberg, R.
dc.contributor.authorGuloksuz, S.
dc.contributor.authorPries, L. K.
dc.contributor.authorDelespaul, P.
dc.contributor.authorKenis, G.
dc.contributor.authorLuykx, J. J.
dc.contributor.authorLin, B. D.
dc.contributor.authorRichards, A. L.
dc.contributor.authorAkdede, B.
dc.contributor.authorBinbay, T.
dc.contributor.authorAltınyazar, V.
dc.contributor.authorYalınçetin, B.
dc.contributor.authorGümüş-Akay, G.
dc.contributor.authorCihan, B.
dc.contributor.authorSoygür, H.
dc.contributor.authorUlaş, H.
dc.contributor.authorŞahin Cankurtaran, E.
dc.contributor.authorUlusoy Kaymak, S.
dc.contributor.authorMihaljevic, M. M.
dc.contributor.authorAndric Petrovic, S.
dc.contributor.authorMirjanic, T.
dc.contributor.authorBernardo, M.
dc.contributor.authorCabrera, B.
dc.contributor.authorBobes, J.
dc.contributor.authorSaiz, P. A.
dc.contributor.authorGarcía-Portilla, M. P.
dc.contributor.authorSanjuan, J.
dc.contributor.authorAguilar, E. J.
dc.contributor.authorLuis Santos, J.
dc.contributor.authorJiménez-López, E.
dc.contributor.authorARROJO ROMERO, MANUEL 
dc.contributor.authorCarracedo Álvarez, Ángel
dc.contributor.authorLópez, G.
dc.contributor.authorGonzález-Peñas, J.
dc.contributor.authorParellada, M.
dc.contributor.authorMaric, N. P.
dc.contributor.authorAtbaşoğlu, C.
dc.contributor.authorUcok, A.
dc.contributor.authorAlptekin, K.
dc.contributor.authorCan Saka, M.
dc.contributor.authorArango, C.
dc.contributor.authorRutten, B. P. F.
dc.contributor.authorvan Os, J.
dc.date.accessioned2021-10-14T12:58:26Z
dc.date.available2021-10-14T12:58:26Z
dc.date.issued2019
dc.identifier.issn1664-0640
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31607966
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774265/pdf/fpsyt-10-00676.pdf
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15546
dc.description.abstractIntroduction: White noise speech illusions index liability for psychotic disorder in case-control comparisons. In the current study, we examined i) the rate of white noise speech illusions in siblings of patients with psychotic disorder and ii) to what degree this rate would be contingent on exposure to known environmental risk factors (childhood adversity and recent life events) and level of known endophenotypic dimensions of psychotic disorder [psychotic experiences assessed with the Community Assessment of Psychic Experiences (CAPE) scale and cognitive ability]. Methods: The white noise task was used as an experimental paradigm to elicit and measure speech illusions in 1,014 patients with psychotic disorders, 1,157 siblings, and 1,507 healthy participants. We examined associations between speech illusions and increasing familial risk (control -> sibling -> patient), modeled as both a linear and a categorical effect, and associations between speech illusions and level of childhood adversities and life events as well as with CAPE scores and cognitive ability scores. Results: While a positive association was found between white noise speech illusions across hypothesized increasing levels of familial risk (controls -> siblings -> patients) [odds ratio (OR) linear 1.11, 95% confidence interval (CI) 1.02-1.21, p = 0.019], there was no evidence for a categorical association with sibling status (OR 0.93, 95% CI 0.79-1.09, p = 0.360). The association between speech illusions and linear familial risk was greater if scores on the CAPE positive scale were higher (p interaction = 0.003; ORlow CAPE positive scale 0.96, 95% CI 0.85-1.07; ORhigh CAPE positive scale 1.26, 95% CI 1.09-1.46); cognitive ability was lower (p interaction < 0.001; ORhigh cognitive ability 0.94, 95% CI 0.84-1.05; ORlow cognitive ability 1.43, 95% CI 1.23-1.68); and exposure to childhood adversity was higher (p interaction < 0.001; ORlow adversity 0.92, 95% CI 0.82-1.04; ORhigh adversity 1.31, 95% CI 1.13-1.52). A similar, although less marked, pattern was seen for categorical patient-control and sibling-control comparisons. Exposure to recent life events did not modify the association between white noise and familial risk (p interaction = 0.232). Conclusion: The association between white noise speech illusions and familial risk is contingent on additional evidence of endophenotypic expression and of exposure to childhood adversity. Therefore, speech illusions may represent a trait-dependent risk marker.
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleWhite Noise Speech Illusions: A Trait-Dependent Risk Marker for Psychotic Disorder?
dc.typeArtigoes
dc.authorsophosCarracedo Álvarez, Ángel
dc.authorsophosArrojo Romero, Manuel
dc.identifier.doi10.3389/fpsyt.2019.00676
dc.identifier.pmid31607966
dc.identifier.sophos30988
dc.issue.number10
dc.journal.titleFRONTIERS IN PSYCHIATRY
dc.organizationServizo Galego de Saúde::Dirección Xeral de Asistencia Sanitaria::Fundación Pública Galega de Medicina Xenómica
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Psiquiatría
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
dc.page.initial676es
dc.rights.accessRightsopenAccess
dc.subject.keywordFPGMX
dc.subject.keywordCHUS
dc.subject.keywordIDIS
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)
dc.typesophosArtículo Original
dc.volume.number10


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