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Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes

dc.contributor.authorNeafsey, D. E.
dc.contributor.authorWaterhouse, R. M.
dc.contributor.authorAbai, M. R.
dc.contributor.authorAganezov, S. S.
dc.contributor.authorAlekseyev, M. A.
dc.contributor.authorAllen, J. E.
dc.contributor.authorAmon, J.
dc.contributor.authorArca, B.
dc.contributor.authorArensburger, P.
dc.contributor.authorArtemov, G.
dc.contributor.authorAssour, L. A.
dc.contributor.authorBasseri, H.
dc.contributor.authorBerlin, A.
dc.contributor.authorBirren, B. W.
dc.contributor.authorBlandin, S. A.
dc.contributor.authorBrockman, A. I.
dc.contributor.authorBurkot, T. R.
dc.contributor.authorBurt, A.
dc.contributor.authorChan, C. S.
dc.contributor.authorChauve, C.
dc.contributor.authorChiu, J. C.
dc.contributor.authorChristensen, M.
dc.contributor.authorCostantini, C.
dc.contributor.authorDavidson, V. L.
dc.contributor.authorDeligianni, E.
dc.contributor.authorDottorini, T.
dc.contributor.authorDritsou, V.
dc.contributor.authorGabriel, S. B.
dc.contributor.authorGuelbeogo, W. M.
dc.contributor.authorHall, A. B.
dc.contributor.authorHan, M. V.
dc.contributor.authorHlaing, T.
dc.contributor.authorHughes, D. S.
dc.contributor.authorJenkins, A. M.
dc.contributor.authorJiang, X.
dc.contributor.authorJungreis, I.
dc.contributor.authorKakani, E. G.
dc.contributor.authorKamali, M.
dc.contributor.authorKemppainen, P.
dc.contributor.authorKennedy, R. C.
dc.contributor.authorKirmitzoglou, I. K.
dc.contributor.authorKoekemoer, L. L.
dc.contributor.authorLaban, N.
dc.contributor.authorLangridge, N.
dc.contributor.authorLawniczak, M. K.
dc.contributor.authorLirakis, M.
dc.contributor.authorLobo, N. F.
dc.contributor.authorLowy, E.
dc.contributor.authorMacCallum, R. M.
dc.contributor.authorMao, C.
dc.contributor.authorMaslen, G.
dc.contributor.authorMbogo, C.
dc.contributor.authorMcCarthy, J.
dc.contributor.authorMichel, K.
dc.contributor.authorMitchell, S. N.
dc.contributor.authorMoore, W.
dc.contributor.authorMurphy, K. A.
dc.contributor.authorNaumenko, A. N.
dc.contributor.authorNolan, T.
dc.contributor.authorNovoa, E. M.
dc.contributor.authorO'Loughlin, S.
dc.contributor.authorOringanje, C.
dc.contributor.authorOshaghi, M. A.
dc.contributor.authorPakpour, N.
dc.contributor.authorPapathanos, P. A.
dc.contributor.authorPeery, A. N.
dc.contributor.authorPovelones, M.
dc.contributor.authorPrakash, A.
dc.contributor.authorPrice, D. P.
dc.contributor.authorRajaraman, A.
dc.contributor.authorReimer, L. J.
dc.contributor.authorRinker, D. C.
dc.contributor.authorRokas, A.
dc.contributor.authorRussell, T. L.
dc.contributor.authorSagnon, N.
dc.contributor.authorSharakhova, M. V.
dc.contributor.authorShea, T.
dc.contributor.authorSimao, F. A.
dc.contributor.authorSimard, F.
dc.contributor.authorSlotman, M. A.
dc.contributor.authorSomboon, P.
dc.contributor.authorStegniy, V.
dc.contributor.authorStruchiner, C. J.
dc.contributor.authorThomas, G. W.
dc.contributor.authorTojo Castro, Marta
dc.contributor.authorTopalis, P.
dc.contributor.authorTubio, J. M.
dc.contributor.authorUnger, M. F.
dc.contributor.authorVontas, J.
dc.contributor.authorWalton, C.
dc.contributor.authorWilding, C. S.
dc.contributor.authorWillis, J. H.
dc.contributor.authorWu, Y. C.
dc.contributor.authorYan, G.
dc.contributor.authorZdobnov, E. M.
dc.contributor.authorZhou, X.
dc.contributor.authorCatteruccia, F.
dc.contributor.authorChristophides, G. K.
dc.contributor.authorCollins, F. H.
dc.contributor.authorCornman, R. S.
dc.contributor.authorCrisanti, A.
dc.contributor.authorDonnelly, M. J.
dc.contributor.authorEmrich, S. J.
dc.contributor.authorFontaine, M. C.
dc.contributor.authorGelbart, W.
dc.contributor.authorHahn, M. W.
dc.contributor.authorHansen, I. A.
dc.contributor.authorHowell, P. I.
dc.contributor.authorKafatos, F. C.
dc.contributor.authorKellis, M.
dc.contributor.authorLawson, D.
dc.contributor.authorLouis, C.
dc.contributor.authorLuckhart, S.
dc.contributor.authorMuskavitch, M. A.
dc.contributor.authorRibeiro, J. M.
dc.contributor.authorRiehle, M. A.
dc.contributor.authorSharakhov, I. V.
dc.contributor.authorTu, Z.
dc.contributor.authorZwiebel, L. J.
dc.contributor.authorBesansky, N. J.
dc.date.accessioned2017-06-07T06:52:49Z
dc.date.available2017-06-07T06:52:49Z
dc.date.issued2015
dc.identifier.issn0036-8075
dc.identifier.urihttp://hdl.handle.net/20.500.11940/155
dc.description.abstractVariation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.
dc.language.isoeng
dc.subject.meshAnimals
dc.subject.meshAnopheles
dc.subject.meshBase Sequence
dc.subject.meshChromosomes, Insect
dc.subject.meshDrosophila
dc.subject.meshEvolution, Molecular
dc.subject.meshGenome, Insect
dc.subject.meshHumans
dc.subject.meshInsect Vectors
dc.subject.meshMalari
dc.subject.meshMolecular Sequence Data
dc.subject.meshPhylogeny
dc.subject.meshSequence Alignment
dc.titleMosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes
dc.typeArtigoes
dc.authorsophosNeafsey, D. E.
dc.authorsophosWaterhouse, R. M.
dc.authorsophosAbai, M. R.
dc.authorsophosAganezov, S. S.
dc.authorsophosAlekseyev, M. A.
dc.authorsophosAllen, J. E.
dc.authorsophosAmon, J.
dc.authorsophosArca, B.
dc.authorsophosArensburger, P.
dc.authorsophosArtemov, G.
dc.authorsophosAssour, L. A.
dc.authorsophosBasseri, H.
dc.authorsophosBerlin, A.
dc.authorsophosBirren, B. W.
dc.authorsophosBlandin, S. A.
dc.authorsophosBrockman, A. I.
dc.authorsophosBurkot, T. R.
dc.authorsophosBurt, A.
dc.authorsophosChan, C. S.
dc.authorsophosChauve, C.
dc.authorsophosChiu, J. C.
dc.authorsophosChristensen, M.
dc.authorsophosCostantini, C.
dc.authorsophosDavidson, V. L.
dc.authorsophosDeligianni, E.
dc.authorsophosDottorini, T.
dc.authorsophosDritsou, V.
dc.authorsophosGabriel, S. B.
dc.authorsophosGuelbeogo, W. M.
dc.authorsophosHall, A. B.
dc.authorsophosHan, M. V.
dc.authorsophosHlaing, T.
dc.authorsophosHughes, D. S.
dc.authorsophosJenkins, A. M.
dc.authorsophosJiang, X.
dc.authorsophosJungreis, I.
dc.authorsophosKakani, E. G.
dc.authorsophosKamali, M.
dc.authorsophosKemppainen, P.
dc.authorsophosKennedy, R. C.
dc.authorsophosKirmitzoglou, I. K.
dc.authorsophosKoekemoer, L. L.
dc.authorsophosLaban, N.
dc.authorsophosLangridge, N.
dc.authorsophosLawniczak, M. K.
dc.authorsophosLirakis, M.
dc.authorsophosLobo, N. F.
dc.authorsophosLowy, E.
dc.authorsophosMacCallum, R. M.
dc.authorsophosMao, C.
dc.authorsophosMaslen, G.
dc.authorsophosMbogo, C.
dc.authorsophosMcCarthy, J.
dc.authorsophosMichel, K.
dc.authorsophosMitchell, S. N.
dc.authorsophosMoore, W.
dc.authorsophosMurphy, K. A.
dc.authorsophosNaumenko, A. N.
dc.authorsophosNolan, T.
dc.authorsophosNovoa, E. M.
dc.authorsophosO'Loughlin, S.
dc.authorsophosOringanje, C.
dc.authorsophosOshaghi, M. A.
dc.authorsophosPakpour, N.
dc.authorsophosPapathanos, P. A.
dc.authorsophosPeery, A. N.
dc.authorsophosPovelones, M.
dc.authorsophosPrakash, A.
dc.authorsophosPrice, D. P.
dc.authorsophosRajaraman, A.
dc.authorsophosReimer, L. J.
dc.authorsophosRinker, D. C.
dc.authorsophosRokas, A.
dc.authorsophosRussell, T. L.
dc.authorsophosSagnon, N.
dc.authorsophosSharakhova, M. V.
dc.authorsophosShea, T.
dc.authorsophosSimao, F. A.
dc.authorsophosSimard, F.
dc.authorsophosSlotman, M. A.
dc.authorsophosSomboon, P.
dc.authorsophosStegniy, V.
dc.authorsophosStruchiner, C. J.
dc.authorsophosThomas, G. W.
dc.authorsophosTojo, M.
dc.authorsophosTopalis, P.
dc.authorsophosTubio, J. M.
dc.authorsophosUnger, M. F.
dc.authorsophosVontas, J.
dc.authorsophosWalton, C.
dc.authorsophosWilding, C. S.
dc.authorsophosWillis, J. H.
dc.authorsophosWu, Y. C.
dc.authorsophosYan, G.
dc.authorsophosZdobnov, E. M.
dc.authorsophosZhou, X.
dc.authorsophosCatteruccia, F.
dc.authorsophosChristophides, G. K.
dc.authorsophosCollins, F. H.
dc.authorsophosCornman, R. S.
dc.authorsophosCrisanti, A.
dc.authorsophosDonnelly, M. J.
dc.authorsophosEmrich, S. J.
dc.authorsophosFontaine, M. C.
dc.authorsophosGelbart, W.
dc.authorsophosHahn, M. W.
dc.authorsophosHansen, I. A.
dc.authorsophosHowell, P. I.
dc.authorsophosKafatos, F. C.
dc.authorsophosKellis, M.
dc.authorsophosLawson, D.
dc.authorsophosLouis, C.
dc.authorsophosLuckhart, S.
dc.authorsophosMuskavitch, M. A.
dc.authorsophosRibeiro, J. M.
dc.authorsophosRiehle, M. A.
dc.authorsophosSharakhov, I. V.
dc.authorsophosTu, Z.
dc.authorsophosZwiebel, L. J.
dc.authorsophosBesansky, N. J.
dc.identifier.doi10.1126/science.1258522
dc.identifier.isi347102300042
dc.identifier.pmid25554792
dc.identifier.sophos18675
dc.issue.number6217
dc.journal.titleSCIENCE
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.page.initial1258522
dc.rights.accessRightsopenAccess
dc.typesophosArtículo Original
dc.volume.number347


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