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dc.contributor.authorBonar-Alvarez, P.
dc.contributor.authorPérez Sayáns, Mario
dc.contributor.authorGarcía García, Abel 
dc.contributor.authorChamorro Petronacci, Cintia Micaela
dc.contributor.authorGandara-Vila, P.
dc.contributor.authorLuces-Gonzalez, R.
dc.contributor.authorRey, E. O.
dc.contributor.authorBlanco-Carrion, A.
dc.contributor.authorSuárez Peñaranda, Jose Manuel 
dc.date.accessioned2021-10-19T06:52:16Z
dc.date.available2021-10-19T06:52:16Z
dc.date.issued2019
dc.identifier.issn0025-7974
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/30813189
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408116/pdf/medi-98-e14614.pdf
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15604
dc.description.abstractOral lichen planus (OLP) is a common, chronic, inflammatory disease of autoimmune origin. The aim of this study is to determine the correlation of the histopathological features with clinical aspects and variants of OLP.We have retrospectively studied a group of 59 adult patients with confirmed clinical and histopathological diagnosis of OLP from the Oral Pathology Unit of the University of Santiago de Compostela (Spain). Clinical parameters: age, gender, location of the lesions, clinical type, toxic habits, and concomitant treatments were evaluated. Histopathologically, the epithelial response (hyperplasia vs atrophy), presence of ulceration, degree of interface lesion and distribution, intensity, and composition of the inflammatory infiltrate were analyzed.Patients treated with several systemic drugs had more atrophic/erosive forms of OLP (P = .019). Plasma cells were found more commonly in cases showing deep inflammatory involvement of the connective subepithelial tissue than in those where inflammation was only superficially located (P <.001). Their presence was also associated with epithelial erosion-ulceration (P <.01).In conclusion, patients treated with several drugs had more atrophic/erosive forms of OLP and frequently associated with a deep specific inflammatory pattern based on plasma cells. Our results could suggest that drug intake by some patients might confer a supplementary aggravating character to the disease, alone or in conjunction with other non-identified factors. More studies should be carried out to confirm this trend and to assess whether this characteristic, can actually influence the evolution of the lesions.
dc.rightsAtribución-NoComercial 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.meshAdult*
dc.subject.meshLichen Planus*
dc.subject.meshMiddle Aged*
dc.subject.meshHumans*
dc.subject.meshMouth*
dc.subject.meshRetrospective Studies*
dc.subject.meshAged*
dc.titleCorrelation between clinical and pathological features of oral lichen planus A retrospective observational study
dc.typeArtigoes
dc.authorsophosPérez Sayáns, Mario
dc.authorsophosGarcía García, Abel
dc.authorsophosSuárez Peñaranda, Jose Manuel
dc.authorsophosChamorro Petronacci, Cintia Micaela
dc.identifier.doi10.1097/md.0000000000014614
dc.identifier.pmid30813189
dc.identifier.sophos31098
dc.issue.number8
dc.journal.titleMEDICINE
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Anatomía Patolóxica
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Cirurxía Maxilofacial
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
dc.rights.accessRightsopenAccess
dc.subject.decsliquen plano*
dc.subject.decsanciano*
dc.subject.decsestudios retrospectivos*
dc.subject.decsmediana edad*
dc.subject.decshumanos*
dc.subject.decsadulto*
dc.subject.decsboca*
dc.subject.keywordCHUS
dc.subject.keywordIDIS
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)
dc.typesophosArtículo Original
dc.volume.number98


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Atribución-NoComercial 4.0 Internacional
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