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Phase III Trial of Prophylactic Cranial Irradiation with or without Hippocampal Avoidance for SMALL-CELL LUNG Cancer
dc.contributor.author | De Dios, N. R. | |
dc.contributor.author | Murcia, M. | |
dc.contributor.author | Counago, F. | |
dc.contributor.author | Lopez, J. | |
dc.contributor.author | Oses, M. R. | |
dc.contributor.author | Ots, P. M. S. | |
dc.contributor.author | Vallejo, C. | |
dc.contributor.author | Tirado, F. J. L. | |
dc.contributor.author | Garayo, I. T. | |
dc.contributor.author | Garcia, C. C. | |
dc.contributor.author | Sotoca, A. | |
dc.contributor.author | Gispert, J. D. | |
dc.contributor.author | Farre, N. | |
dc.contributor.author | Manero, R. M. | |
dc.contributor.author | Font, J. C. | |
dc.contributor.author | De La Pena, M. J. | |
dc.contributor.author | Jorda, X. D. | |
dc.contributor.author | Gonzalez, C. O. | |
dc.contributor.author | Trueba, T. R. | |
dc.contributor.author | Blanco Ulla, Miguel | |
dc.contributor.author | Bacaicoa, M. C. | |
dc.contributor.author | Torrente, M. | |
dc.contributor.author | Montero, M. | |
dc.contributor.author | Torres, A. A. | |
dc.contributor.author | Vera, J. E. | |
dc.contributor.author | San Millan, J. M. | |
dc.contributor.author | Calvo Crespo, Patricia | |
dc.date.accessioned | 2021-10-28T10:21:29Z | |
dc.date.available | 2021-10-28T10:21:29Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0360-3016 | |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/15626 | |
dc.description.abstract | Purpose/Objective(s) Clinical evidence suggests that radiation dose received by the hippocampus during whole brain radiotherapy may play a role in radiation-induced neurocognitive decline. To prospectively evaluate the neurocognitive (NC) benefit of hippocampal sparing (PCI-HA), we have developed a phase III clinical trial (PREMER) to test hippocampal sparing during PCI. Materials/Methods 118 patients undergoing PCI were randomized to receive PCI (n=60) or PCI-HA (n=58). The hippocampus was contoured, and hippocampal avoidance regions were created using a 5-mm volumetric expansion around the hippocampus. Linear accelerator –based intensity-modulated radiotherapy and Volumetric Modulated Arc Therapy treatment plans were generated for a prescription dose of 25 Gy in 10 fractions. The main objective was NC function at 3 months assessed by Free and Cued Selective Reminding Test (FCSRT). The FCSRT is a well-validated and reliable assessment of memory, including encoding, retrieval, and retention of new information over time. Results These treatment modalities spared the hippocampus, with a D100 of 8.4 ± 2.0 Gy and a maximum dose of 14.5 ± 3.3 Gy. There was a decline in free delayed recall in PCI vs PCI-HA arm at 3 months (21.7 vs 5.1%; p 0.01; OR 5 [IC 95% 1.36-18.87]) at 6 months (32.6 vs 7.3%; p 0.008; OR 6.1 [IC 95% 1.60-23.29]) and at 12 months (18.5 vs 3.8%; p 0.09; OR 5.7 [IC 95% 0.61-52.42]) Conclusion There was a significant decline in memory in PCI group. Further investigation to assess its impact on long-term follow-up is in progress. | |
dc.title | Phase III Trial of Prophylactic Cranial Irradiation with or without Hippocampal Avoidance for SMALL-CELL LUNG Cancer | |
dc.type | Publicación de congreso | es |
dc.authorsophos | Calvo Crespo, Patricia | |
dc.authorsophos | Blanco Ulla, Miguel | |
dc.identifier.doi | 10.1016/j.ijrobp.2019.06.451 | |
dc.identifier.sophos | 31187 | |
dc.issue.number | 1 | |
dc.journal.title | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Radiodiagnóstico | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Oncoloxía Radioterápica | |
dc.page.initial | s35 | es |
dc.page.final | s36 | es |
dc.relation.publisherversion | https://www.redjournal.org/article/S0360-3016(19)31286-6/pdf | |
dc.subject.keyword | CHUS | |
dc.typefides | Comunicaciones a congresos | |
dc.typesophos | Comunicaciones a congresos | |
dc.volume.number | 105 |