Antimicrobial management of Tropheryma whipplei endocarditis: the Spanish Collaboration on Endocarditis (GAMES) experience
dc.contributor.author | Garcia-Alvarez, L. | |
dc.contributor.author | Sanz, M. M. | |
dc.contributor.author | Marin, M. | |
dc.contributor.author | Farinas, M. C. | |
dc.contributor.author | Montejo, M. | |
dc.contributor.author | Goikoetxea, J. | |
dc.contributor.author | Garcia, R. R. | |
dc.contributor.author | de Alarcon, A. | |
dc.contributor.author | Almela, M. | |
dc.contributor.author | Fernandez-Hidalgo, N. | |
dc.contributor.author | Socas, M. M. A. | |
dc.contributor.author | Goenaga, M. A. | |
dc.contributor.author | Navas, E. | |
dc.contributor.author | Vicioso, L. | |
dc.contributor.author | Oteo, J. A. | |
dc.contributor.author | Adan, I. | |
dc.contributor.author | Sanchez, F. F. | |
dc.contributor.author | Noureddine, M. | |
dc.contributor.author | Rosas, G. | |
dc.contributor.author | Lima, J. D. | |
dc.contributor.author | Aramendi, J. | |
dc.contributor.author | Bereciartua, E. | |
dc.contributor.author | Boado, M. V. | |
dc.contributor.author | Lazaro, M. C. | |
dc.contributor.author | Goiti, J. J. | |
dc.contributor.author | Hernandez, J. L. | |
dc.contributor.author | Iruretagoyena, J. R. | |
dc.contributor.author | Zuazabal, J. I. | |
dc.contributor.author | Lopez-Soria, L. | |
dc.contributor.author | Perez, P. M. | |
dc.contributor.author | Rodriguez, R. | |
dc.contributor.author | Voces, R. | |
dc.contributor.author | Lopez, M. V. G. | |
dc.contributor.author | Georgieva, R. I. | |
dc.contributor.author | Solero, M. M. | |
dc.contributor.author | Bailon, I. R. | |
dc.contributor.author | Morales, J. R. | |
dc.contributor.author | Cuende, A. M. | |
dc.contributor.author | Echeverria, T. | |
dc.contributor.author | Fuerte, A. | |
dc.contributor.author | Gaminde, E. | |
dc.contributor.author | Idigoras, P. | |
dc.contributor.author | Iribarren, J. A. | |
dc.contributor.author | Yarza, A. I. | |
dc.contributor.author | Urkola, X. K. | |
dc.contributor.author | Reviejo, C. | |
dc.contributor.author | Carrasco, R. | |
dc.contributor.author | Climent, V. | |
dc.contributor.author | Llamas, P. | |
dc.contributor.author | Merino, E. | |
dc.contributor.author | Plazas, J. | |
dc.contributor.author | Reus, S. | |
dc.contributor.author | Alvarez, N. | |
dc.contributor.author | Bravo-Ferrer, J. M. | |
dc.contributor.author | Castelo, L. | |
dc.contributor.author | Cuenca, J. | |
dc.contributor.author | Llinares, P. | |
dc.contributor.author | Rey, E. M. | |
dc.contributor.author | Mayo, M. R. | |
dc.contributor.author | Sanchez, E. | |
dc.contributor.author | Regueiro, D. S. | |
dc.contributor.author | Martinez, F. J. | |
dc.contributor.author | Alonso, M. D. | |
dc.contributor.author | Castro, B. | |
dc.contributor.author | Marrero, D. G. | |
dc.contributor.author | Duran, M. D. | |
dc.contributor.author | Gomez, M. A. M. | |
dc.contributor.author | La Calzada, J. | |
dc.contributor.author | Nassar, I. | |
dc.contributor.author | Ciezar, A. P. | |
dc.contributor.author | Iglesias, J. M. R. | |
dc.contributor.author | Alvarez, V. A. | |
dc.contributor.author | Costas, C. | |
dc.contributor.author | de la Hera, J. | |
dc.contributor.author | Suarez, J. F. | |
dc.contributor.author | Fraile, L. I. | |
dc.contributor.author | Arguero, V. L. | |
dc.contributor.author | Menendez, J. L. | |
dc.contributor.author | Bajo, P. M. | |
dc.contributor.author | Morales, C. | |
dc.contributor.author | Torrico, A. M. | |
dc.contributor.author | Palomo, C. | |
dc.contributor.author | Martinez, B. P. | |
dc.contributor.author | Esteban, A. R. | |
dc.contributor.author | Asensio, M. T. | |
dc.contributor.author | Ambrosioni, J. | |
dc.contributor.author | Armero, Y. | |
dc.contributor.author | Azqueta, M. | |
dc.contributor.author | Brunet, M. | |
dc.contributor.author | Cartana, R. | |
dc.contributor.author | Falces, C. | |
dc.contributor.author | Fita, G. | |
dc.contributor.author | Fuster, D. | |
dc.contributor.author | de la Maria, C. G. | |
dc.contributor.author | Gatell, J. M. | |
dc.contributor.author | Perez, J. L. | |
dc.contributor.author | Manzardo, C. | |
dc.contributor.author | Marco, F. | |
dc.contributor.author | Miro, J. M. | |
dc.contributor.author | Moreno, A. | |
dc.contributor.author | Ninot, S. | |
dc.contributor.author | Quintana, E. | |
dc.contributor.author | Pare, C. | |
dc.contributor.author | Pereda, D. | |
dc.contributor.author | Pericas, J. M. | |
dc.contributor.author | Pomar, J. L. | |
dc.contributor.author | Ramirez, J. | |
dc.contributor.author | Rovira, I. | |
dc.contributor.author | Sitges, M. | |
dc.contributor.author | Soy, D. | |
dc.contributor.author | Tellez, A. | |
dc.contributor.author | Vidal, B. | |
dc.contributor.author | Vila, J. | |
dc.contributor.author | Bermejo, J. | |
dc.contributor.author | Bouza, E. | |
dc.contributor.author | Cuerpo, G. | |
dc.contributor.author | de Egea, V. | |
dc.contributor.author | Eworo, A. | |
dc.contributor.author | Cruz, A. F. | |
dc.contributor.author | Leoni, M. E. G. | |
dc.contributor.author | del Vecchio, M. G. | |
dc.contributor.author | Ramallo, V. G. | |
dc.contributor.author | Hernandez, M. K. | |
dc.contributor.author | Martinez-Selles, M. | |
dc.contributor.author | Menarguez, M. C. | |
dc.contributor.author | Munoz, P. | |
dc.contributor.author | Rincon, C. | |
dc.contributor.author | Rodriguez-Abella, H. | |
dc.contributor.author | Rodriguez-Creixems, M. | |
dc.contributor.author | Pinilla, B. | |
dc.contributor.author | Pinto, A. | |
dc.contributor.author | Valerio, M. | |
dc.contributor.author | Moreno, E. V. | |
dc.contributor.author | Antorrena, I. | |
dc.contributor.author | Loeches, B. | |
dc.contributor.author | Moreno, M. | |
dc.contributor.author | Ramirez, U. | |
dc.contributor.author | Baston, V. R. | |
dc.contributor.author | Romero, M. | |
dc.contributor.author | Saldana, A. | |
dc.contributor.author | Castillo, C. A. | |
dc.contributor.author | Arnaiz, A. | |
dc.contributor.author | Berrazueta, J. | |
dc.contributor.author | Bellisco, S. | |
dc.contributor.author | Belaustegui, M. C. | |
dc.contributor.author | Duran, R. | |
dc.contributor.author | Farinas-Alvarez, C. | |
dc.contributor.author | Mazarrasa, C. F. | |
dc.contributor.author | Izquierdo, R. G. | |
dc.contributor.author | Rico, C. G. | |
dc.contributor.author | Diez, J. G. | |
dc.contributor.author | Duran, R. M. | |
dc.contributor.author | Pajaron, M. | |
dc.contributor.author | Parra, J. A. | |
dc.contributor.author | Teira, R. | |
dc.contributor.author | Zarauza, J. | |
dc.contributor.author | Pavia, P. G. | |
dc.contributor.author | Gonzalez, J. | |
dc.contributor.author | Orden, B. | |
dc.contributor.author | Ramos, A. | |
dc.contributor.author | Gonzalez, E. R. | |
dc.contributor.author | Centella, T. | |
dc.contributor.author | Hermida, J. M. | |
dc.contributor.author | Moya, J. L. | |
dc.contributor.author | Martin-Davila, P. | |
dc.contributor.author | Oliva, E. | |
dc.contributor.author | del Rio, A. | |
dc.contributor.author | Ruiz, S. | |
dc.contributor.author | Tenorio, C. H. | |
dc.contributor.author | de Castro, A. | |
dc.contributor.author | de Cueto, M. | |
dc.contributor.author | Gallego, P. | |
dc.contributor.author | Acebal, J. G. | |
dc.contributor.author | Bano, J. R. | |
dc.contributor.author | Garcia, E. | |
dc.contributor.author | Haro, J. L. | |
dc.contributor.author | Lepe, J. A. | |
dc.contributor.author | Lopez, F. | |
dc.contributor.author | Luque, R. | |
dc.contributor.author | Alonso, L. J. | |
dc.contributor.author | Azcarate, P. | |
dc.contributor.author | Gutierrez, J. M. A. | |
dc.contributor.author | Blanco, J. R. | |
dc.contributor.author | de Benito, N. | |
dc.contributor.author | Gurgui, M. | |
dc.contributor.author | Pacho, C. | |
dc.contributor.author | Pericas, R. | |
dc.contributor.author | Pons, G. | |
dc.contributor.author | Alvarez, M. | |
dc.contributor.author | Fernandez, A. L. | |
dc.contributor.author | Martínez Monzonís, Maria Amparo | |
dc.contributor.author | Prieto, A. | |
dc.contributor.author | Regueiro García, Benito José | |
dc.contributor.author | Tijeira, E. | |
dc.contributor.author | Vega Fernandez, Marino | |
dc.contributor.author | Blasco, A. C. | |
dc.contributor.author | Mollar, J. C. | |
dc.contributor.author | Arana, J. C. G. | |
dc.contributor.author | Uriarte, O. G. | |
dc.contributor.author | Lopez, A. M. | |
dc.contributor.author | de Zarate, Z. O. | |
dc.contributor.author | Matos, J. A. U. | |
dc.contributor.author | Nacle, M. B. | |
dc.contributor.author | Sanchez-Porto, A. | |
dc.contributor.author | Vallejo, L. | |
dc.contributor.author | Leal, J. M. A. | |
dc.contributor.author | Vazquez, E. G. | |
dc.contributor.author | Torres, A. H. | |
dc.contributor.author | Blazquez, A. | |
dc.contributor.author | Valenzuela, G. D. | |
dc.contributor.author | Alonso, A. | |
dc.contributor.author | Aramburu, J. | |
dc.contributor.author | Calvo, F. E. | |
dc.contributor.author | Rodriguez, A. M. | |
dc.contributor.author | Tarabini-Castellani, P. | |
dc.contributor.author | Galvez, E. H. | |
dc.contributor.author | Bellido, C. M. | |
dc.contributor.author | Pau, J. L. | |
dc.contributor.author | Sepulveda, M. A. | |
dc.contributor.author | Sierra, P. T. | |
dc.contributor.author | Iqbal-Mirza, S. Z. | |
dc.contributor.author | Alcolea, E. C. | |
dc.contributor.author | Serrano, P. E. | |
dc.contributor.author | Roca, J. J. H. | |
dc.contributor.author | Escobar, E. M. | |
dc.contributor.author | Monje, A. P. | |
dc.contributor.author | Cabrera, V. S. | |
dc.contributor.author | Garcia, D. V. | |
dc.contributor.author | Luna, C. C. | |
dc.contributor.author | Morcillo, J. N. | |
dc.contributor.author | Seco, M. C. P. | |
dc.contributor.author | Spanish Collaboration, Endocarditis | |
dc.date.accessioned | 2021-11-04T10:48:47Z | |
dc.date.available | 2021-11-04T10:48:47Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0305-7453 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/30789210 | es |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/30789210 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/15639 | |
dc.description.abstract | OBJECTIVES: Tropheryma whipplei has been detected in 3.5% of the blood culture-negative cases of endocarditis in Spain. Experience in the management of T. whipplei endocarditis is limited. Here we report the long-term outcome of the treatment of previously reported patients who were diagnosed with infective endocarditis (IE) caused by T. whipplei from the Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis Infecciosa en Espana (GAMES) and discuss potential options for antimicrobial therapy for IE caused by T. whipplei. PATIENTS AND METHODS: Seventeen patients with T. whipplei endocarditis were recruited between 2008 and 2014 in 25 Spanish hospitals. Patients were classified according to the therapeutic regimen: ceftriaxone and trimethoprim/sulfamethoxazole, doxycycline + hydroxychloroquine and other treatment options. RESULTS: Follow-up data were obtained from 14 patients. The median follow-up was 46.5 months. All patients completed the antibiotic treatment prescribed, with a median duration of 13 months. Six patients were treated with ceftriaxone and trimethoprim/sulfamethoxazole (median duration 13 months), four with doxycycline + hydroxychloroquine (median duration 13.8 months) and four with other treatment options (median duration 22.3 months). The follow-up after the end of the treatments was between 5 and 84 months (median 24 months). CONCLUSIONS: All treatment lines were effective and well tolerated. Therapeutic failures were not detected during the treatment. None of the patients died or experienced a relapse during the follow-up. Only six patients received antibiotic treatment in accordance with guidelines. These data suggest that shorter antimicrobial treatments could be effective. | en |
dc.language.iso | eng | es |
dc.subject.mesh | Drug Therapy | * |
dc.subject.mesh | Endocarditis | * |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Treatment Outcome | * |
dc.subject.mesh | Follow-Up Studies | * |
dc.subject.mesh | Tropheryma | * |
dc.subject.mesh | Anti-Bacterial Agents | * |
dc.subject.mesh | Aged | * |
dc.title | Antimicrobial management of Tropheryma whipplei endocarditis: the Spanish Collaboration on Endocarditis (GAMES) experience | es |
dc.type | Artigo | es |
dc.identifier.doi | 10.1093/jac/dkz059 | |
dc.identifier.pmid | 30789210 | |
dc.identifier.sophos | 31227 | |
dc.issue.number | 6 | es |
dc.journal.title | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Cardioloxía | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Microbioloxía | es |
dc.page.initial | 1713 | es |
dc.page.final | 1717 | es |
dc.relation.publisherversion | https://watermark.silverchair.com/dkz059.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAApowggKWBgkqhkiG9w0BBwagggKHMIICgwIBADCCAnwGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM8YO84gG6gX6D1nybAgEQgIICTSRaTe_DdQ8k37Hpx_RivcUc7zFIrNXmTIGV5v0RV4QXcBBgS75MJfXYyyCFYM4H-VsFNr-p9aS1cu96vQIELqUug_qGpIsHoBUOiJ_4JfB6GI9mEOafo2y4D-MKYjipgHKV5Fkq3s49f15CCyNkuq6t5EKjD1I2onTIUW5ZUev2BMovcR3cBTUC-KUax-BAptcI68Xi-FaD6XFilV1oz0F84KYmrl7m8iycs2s7TJtvGZNaCtcmLG8gVKcfXuY22d-33Yxw4SBLjOkByIXHATmWDGKTNvqF-3dPsV1POW4KQjDS6gwikXiX_6g8UUnI8sOrbYT_1kKxl3yQpL51S1ORP6GZmf1Lh5gEeVmu-ebZmsUv0vDbPt3V7H8Rh98MmyIaDeAEVTXc2Ifaoa-alK_dsYou0zwcqvJT2uwD09V0BVDmm9I34FVQ63yM1o4zGAKSnUrIaN1Ljdq9IHRo7NfSPZMeJdN_LUFBzmOrMdhRQN-kQqYX8D9BsJuYht4TYI6KPcXPQYcjqWD5fsSn_-2PIOtw9V-tQ7HFAl0AT4mfHltdVRS42jMKA9CJ02OL8UeWQVZ2rxKgZaikP7ZFmZ2S2l4-SrrfkS1sutuAdnx8PrVVoFI_Y2mHVYnMnTluYQwXkwahf0A2zW1yTnVo743fX_r9MflqAHc2PVbDHLT4st7NUrZU3RzfeaNPabKtM1ZbFHBosySfxziO5x7fOd70e_f9rJfcXjvuKGNpwEksmJWatl6q3hTrbMbeQkBBeqbBoRCS50jaA_BssFQ | es |
dc.rights.accessRights | embargoedAccess | es |
dc.subject.decs | resultado del tratamiento | * |
dc.subject.decs | anciano | * |
dc.subject.decs | endocarditis | * |
dc.subject.decs | estudios de seguimiento | * |
dc.subject.decs | Tropheryma | * |
dc.subject.decs | mediana edad | * |
dc.subject.decs | farmacoterapia | * |
dc.subject.decs | humanos | * |
dc.subject.decs | antibacterianos | * |
dc.subject.keyword | CHUS | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 74 | es |