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dc.contributor.authorGarcia-Alvarez, L.
dc.contributor.authorSanz, M. M.
dc.contributor.authorMarin, M.
dc.contributor.authorFarinas, M. C.
dc.contributor.authorMontejo, M.
dc.contributor.authorGoikoetxea, J.
dc.contributor.authorGarcia, R. R.
dc.contributor.authorde Alarcon, A.
dc.contributor.authorAlmela, M.
dc.contributor.authorFernandez-Hidalgo, N.
dc.contributor.authorSocas, M. M. A.
dc.contributor.authorGoenaga, M. A.
dc.contributor.authorNavas, E.
dc.contributor.authorVicioso, L.
dc.contributor.authorOteo, J. A.
dc.contributor.authorAdan, I.
dc.contributor.authorSanchez, F. F.
dc.contributor.authorNoureddine, M.
dc.contributor.authorRosas, G.
dc.contributor.authorLima, J. D.
dc.contributor.authorAramendi, J.
dc.contributor.authorBereciartua, E.
dc.contributor.authorBoado, M. V.
dc.contributor.authorLazaro, M. C.
dc.contributor.authorGoiti, J. J.
dc.contributor.authorHernandez, J. L.
dc.contributor.authorIruretagoyena, J. R.
dc.contributor.authorZuazabal, J. I.
dc.contributor.authorLopez-Soria, L.
dc.contributor.authorPerez, P. M.
dc.contributor.authorRodriguez, R.
dc.contributor.authorVoces, R.
dc.contributor.authorLopez, M. V. G.
dc.contributor.authorGeorgieva, R. I.
dc.contributor.authorSolero, M. M.
dc.contributor.authorBailon, I. R.
dc.contributor.authorMorales, J. R.
dc.contributor.authorCuende, A. M.
dc.contributor.authorEcheverria, T.
dc.contributor.authorFuerte, A.
dc.contributor.authorGaminde, E.
dc.contributor.authorIdigoras, P.
dc.contributor.authorIribarren, J. A.
dc.contributor.authorYarza, A. I.
dc.contributor.authorUrkola, X. K.
dc.contributor.authorReviejo, C.
dc.contributor.authorCarrasco, R.
dc.contributor.authorCliment, V.
dc.contributor.authorLlamas, P.
dc.contributor.authorMerino, E.
dc.contributor.authorPlazas, J.
dc.contributor.authorReus, S.
dc.contributor.authorAlvarez, N.
dc.contributor.authorBravo-Ferrer, J. M.
dc.contributor.authorCastelo, L.
dc.contributor.authorCuenca, J.
dc.contributor.authorLlinares, P.
dc.contributor.authorRey, E. M.
dc.contributor.authorMayo, M. R.
dc.contributor.authorSanchez, E.
dc.contributor.authorRegueiro, D. S.
dc.contributor.authorMartinez, F. J.
dc.contributor.authorAlonso, M. D.
dc.contributor.authorCastro, B.
dc.contributor.authorMarrero, D. G.
dc.contributor.authorDuran, M. D.
dc.contributor.authorGomez, M. A. M.
dc.contributor.authorLa Calzada, J.
dc.contributor.authorNassar, I.
dc.contributor.authorCiezar, A. P.
dc.contributor.authorIglesias, J. M. R.
dc.contributor.authorAlvarez, V. A.
dc.contributor.authorCostas, C.
dc.contributor.authorde la Hera, J.
dc.contributor.authorSuarez, J. F.
dc.contributor.authorFraile, L. I.
dc.contributor.authorArguero, V. L.
dc.contributor.authorMenendez, J. L.
dc.contributor.authorBajo, P. M.
dc.contributor.authorMorales, C.
dc.contributor.authorTorrico, A. M.
dc.contributor.authorPalomo, C.
dc.contributor.authorMartinez, B. P.
dc.contributor.authorEsteban, A. R.
dc.contributor.authorAsensio, M. T.
dc.contributor.authorAmbrosioni, J.
dc.contributor.authorArmero, Y.
dc.contributor.authorAzqueta, M.
dc.contributor.authorBrunet, M.
dc.contributor.authorCartana, R.
dc.contributor.authorFalces, C.
dc.contributor.authorFita, G.
dc.contributor.authorFuster, D.
dc.contributor.authorde la Maria, C. G.
dc.contributor.authorGatell, J. M.
dc.contributor.authorPerez, J. L.
dc.contributor.authorManzardo, C.
dc.contributor.authorMarco, F.
dc.contributor.authorMiro, J. M.
dc.contributor.authorMoreno, A.
dc.contributor.authorNinot, S.
dc.contributor.authorQuintana, E.
dc.contributor.authorPare, C.
dc.contributor.authorPereda, D.
dc.contributor.authorPericas, J. M.
dc.contributor.authorPomar, J. L.
dc.contributor.authorRamirez, J.
dc.contributor.authorRovira, I.
dc.contributor.authorSitges, M.
dc.contributor.authorSoy, D.
dc.contributor.authorTellez, A.
dc.contributor.authorVidal, B.
dc.contributor.authorVila, J.
dc.contributor.authorBermejo, J.
dc.contributor.authorBouza, E.
dc.contributor.authorCuerpo, G.
dc.contributor.authorde Egea, V.
dc.contributor.authorEworo, A.
dc.contributor.authorCruz, A. F.
dc.contributor.authorLeoni, M. E. G.
dc.contributor.authordel Vecchio, M. G.
dc.contributor.authorRamallo, V. G.
dc.contributor.authorHernandez, M. K.
dc.contributor.authorMartinez-Selles, M.
dc.contributor.authorMenarguez, M. C.
dc.contributor.authorMunoz, P.
dc.contributor.authorRincon, C.
dc.contributor.authorRodriguez-Abella, H.
dc.contributor.authorRodriguez-Creixems, M.
dc.contributor.authorPinilla, B.
dc.contributor.authorPinto, A.
dc.contributor.authorValerio, M.
dc.contributor.authorMoreno, E. V.
dc.contributor.authorAntorrena, I.
dc.contributor.authorLoeches, B.
dc.contributor.authorMoreno, M.
dc.contributor.authorRamirez, U.
dc.contributor.authorBaston, V. R.
dc.contributor.authorRomero, M.
dc.contributor.authorSaldana, A.
dc.contributor.authorCastillo, C. A.
dc.contributor.authorArnaiz, A.
dc.contributor.authorBerrazueta, J.
dc.contributor.authorBellisco, S.
dc.contributor.authorBelaustegui, M. C.
dc.contributor.authorDuran, R.
dc.contributor.authorFarinas-Alvarez, C.
dc.contributor.authorMazarrasa, C. F.
dc.contributor.authorIzquierdo, R. G.
dc.contributor.authorRico, C. G.
dc.contributor.authorDiez, J. G.
dc.contributor.authorDuran, R. M.
dc.contributor.authorPajaron, M.
dc.contributor.authorParra, J. A.
dc.contributor.authorTeira, R.
dc.contributor.authorZarauza, J.
dc.contributor.authorPavia, P. G.
dc.contributor.authorGonzalez, J.
dc.contributor.authorOrden, B.
dc.contributor.authorRamos, A.
dc.contributor.authorGonzalez, E. R.
dc.contributor.authorCentella, T.
dc.contributor.authorHermida, J. M.
dc.contributor.authorMoya, J. L.
dc.contributor.authorMartin-Davila, P.
dc.contributor.authorOliva, E.
dc.contributor.authordel Rio, A.
dc.contributor.authorRuiz, S.
dc.contributor.authorTenorio, C. H.
dc.contributor.authorde Castro, A.
dc.contributor.authorde Cueto, M.
dc.contributor.authorGallego, P.
dc.contributor.authorAcebal, J. G.
dc.contributor.authorBano, J. R.
dc.contributor.authorGarcia, E.
dc.contributor.authorHaro, J. L.
dc.contributor.authorLepe, J. A.
dc.contributor.authorLopez, F.
dc.contributor.authorLuque, R.
dc.contributor.authorAlonso, L. J.
dc.contributor.authorAzcarate, P.
dc.contributor.authorGutierrez, J. M. A.
dc.contributor.authorBlanco, J. R.
dc.contributor.authorde Benito, N.
dc.contributor.authorGurgui, M.
dc.contributor.authorPacho, C.
dc.contributor.authorPericas, R.
dc.contributor.authorPons, G.
dc.contributor.authorAlvarez, M.
dc.contributor.authorFernandez, A. L.
dc.contributor.authorMartínez Monzonís, Maria Amparo 
dc.contributor.authorPrieto, A.
dc.contributor.authorRegueiro García, Benito José 
dc.contributor.authorTijeira, E.
dc.contributor.authorVega Fernandez, Marino 
dc.contributor.authorBlasco, A. C.
dc.contributor.authorMollar, J. C.
dc.contributor.authorArana, J. C. G.
dc.contributor.authorUriarte, O. G.
dc.contributor.authorLopez, A. M.
dc.contributor.authorde Zarate, Z. O.
dc.contributor.authorMatos, J. A. U.
dc.contributor.authorNacle, M. B.
dc.contributor.authorSanchez-Porto, A.
dc.contributor.authorVallejo, L.
dc.contributor.authorLeal, J. M. A.
dc.contributor.authorVazquez, E. G.
dc.contributor.authorTorres, A. H.
dc.contributor.authorBlazquez, A.
dc.contributor.authorValenzuela, G. D.
dc.contributor.authorAlonso, A.
dc.contributor.authorAramburu, J.
dc.contributor.authorCalvo, F. E.
dc.contributor.authorRodriguez, A. M.
dc.contributor.authorTarabini-Castellani, P.
dc.contributor.authorGalvez, E. H.
dc.contributor.authorBellido, C. M.
dc.contributor.authorPau, J. L.
dc.contributor.authorSepulveda, M. A.
dc.contributor.authorSierra, P. T.
dc.contributor.authorIqbal-Mirza, S. Z.
dc.contributor.authorAlcolea, E. C.
dc.contributor.authorSerrano, P. E.
dc.contributor.authorRoca, J. J. H.
dc.contributor.authorEscobar, E. M.
dc.contributor.authorMonje, A. P.
dc.contributor.authorCabrera, V. S.
dc.contributor.authorGarcia, D. V.
dc.contributor.authorLuna, C. C.
dc.contributor.authorMorcillo, J. N.
dc.contributor.authorSeco, M. C. P.
dc.contributor.authorSpanish Collaboration, Endocarditis
dc.date.accessioned2021-11-04T10:48:47Z
dc.date.available2021-11-04T10:48:47Z
dc.date.issued2019
dc.identifier.issn0305-7453
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/30789210es
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/30789210es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15639
dc.description.abstractOBJECTIVES: Tropheryma whipplei has been detected in 3.5% of the blood culture-negative cases of endocarditis in Spain. Experience in the management of T. whipplei endocarditis is limited. Here we report the long-term outcome of the treatment of previously reported patients who were diagnosed with infective endocarditis (IE) caused by T. whipplei from the Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis Infecciosa en Espana (GAMES) and discuss potential options for antimicrobial therapy for IE caused by T. whipplei. PATIENTS AND METHODS: Seventeen patients with T. whipplei endocarditis were recruited between 2008 and 2014 in 25 Spanish hospitals. Patients were classified according to the therapeutic regimen: ceftriaxone and trimethoprim/sulfamethoxazole, doxycycline + hydroxychloroquine and other treatment options. RESULTS: Follow-up data were obtained from 14 patients. The median follow-up was 46.5 months. All patients completed the antibiotic treatment prescribed, with a median duration of 13 months. Six patients were treated with ceftriaxone and trimethoprim/sulfamethoxazole (median duration 13 months), four with doxycycline + hydroxychloroquine (median duration 13.8 months) and four with other treatment options (median duration 22.3 months). The follow-up after the end of the treatments was between 5 and 84 months (median 24 months). CONCLUSIONS: All treatment lines were effective and well tolerated. Therapeutic failures were not detected during the treatment. None of the patients died or experienced a relapse during the follow-up. Only six patients received antibiotic treatment in accordance with guidelines. These data suggest that shorter antimicrobial treatments could be effective.en
dc.language.isoenges
dc.subject.meshDrug Therapy*
dc.subject.meshEndocarditis*
dc.subject.meshMiddle Aged*
dc.subject.meshHumans*
dc.subject.meshTreatment Outcome*
dc.subject.meshFollow-Up Studies*
dc.subject.meshTropheryma*
dc.subject.meshAnti-Bacterial Agents*
dc.subject.meshAged*
dc.titleAntimicrobial management of Tropheryma whipplei endocarditis: the Spanish Collaboration on Endocarditis (GAMES) experiencees
dc.typeArtigoes
dc.identifier.doi10.1093/jac/dkz059
dc.identifier.pmid30789210
dc.identifier.sophos31227
dc.issue.number6es
dc.journal.titleJOURNAL OF ANTIMICROBIAL CHEMOTHERAPYes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Cardioloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Microbioloxíaes
dc.page.initial1713es
dc.page.final1717es
dc.relation.publisherversionhttps://watermark.silverchair.com/dkz059.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAApowggKWBgkqhkiG9w0BBwagggKHMIICgwIBADCCAnwGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM8YO84gG6gX6D1nybAgEQgIICTSRaTe_DdQ8k37Hpx_RivcUc7zFIrNXmTIGV5v0RV4QXcBBgS75MJfXYyyCFYM4H-VsFNr-p9aS1cu96vQIELqUug_qGpIsHoBUOiJ_4JfB6GI9mEOafo2y4D-MKYjipgHKV5Fkq3s49f15CCyNkuq6t5EKjD1I2onTIUW5ZUev2BMovcR3cBTUC-KUax-BAptcI68Xi-FaD6XFilV1oz0F84KYmrl7m8iycs2s7TJtvGZNaCtcmLG8gVKcfXuY22d-33Yxw4SBLjOkByIXHATmWDGKTNvqF-3dPsV1POW4KQjDS6gwikXiX_6g8UUnI8sOrbYT_1kKxl3yQpL51S1ORP6GZmf1Lh5gEeVmu-ebZmsUv0vDbPt3V7H8Rh98MmyIaDeAEVTXc2Ifaoa-alK_dsYou0zwcqvJT2uwD09V0BVDmm9I34FVQ63yM1o4zGAKSnUrIaN1Ljdq9IHRo7NfSPZMeJdN_LUFBzmOrMdhRQN-kQqYX8D9BsJuYht4TYI6KPcXPQYcjqWD5fsSn_-2PIOtw9V-tQ7HFAl0AT4mfHltdVRS42jMKA9CJ02OL8UeWQVZ2rxKgZaikP7ZFmZ2S2l4-SrrfkS1sutuAdnx8PrVVoFI_Y2mHVYnMnTluYQwXkwahf0A2zW1yTnVo743fX_r9MflqAHc2PVbDHLT4st7NUrZU3RzfeaNPabKtM1ZbFHBosySfxziO5x7fOd70e_f9rJfcXjvuKGNpwEksmJWatl6q3hTrbMbeQkBBeqbBoRCS50jaA_BssFQes
dc.rights.accessRightsembargoedAccesses
dc.subject.decsresultado del tratamiento*
dc.subject.decsanciano*
dc.subject.decsendocarditis*
dc.subject.decsestudios de seguimiento*
dc.subject.decsTropheryma*
dc.subject.decsmediana edad*
dc.subject.decsfarmacoterapia*
dc.subject.decshumanos*
dc.subject.decsantibacterianos*
dc.subject.keywordCHUSes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number74es


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