Dissecting the Proton Transport Pathway in Oral Squamous Cell Carcinoma: State of the Art and Theranostics Implications
Identificadores
Identificadores
URI: http://hdl.handle.net/20.500.11940/15674
PMID: 31470498
DOI: 10.3390/ijms20174222
ISSN: 1661-6596
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Visualización o descarga de ficheros
Fecha de publicación
2019Título de revista
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Tipo de contenido
Artigo
DeCS
proteínas de transporte de membrana | carcinoma | concentración de iones hidrógeno | neoplasias de la boca | ATPasas translocadoras de protones vacuolares | humanos | protones | simportadores de sodio-bicarbonatoMeSH
Carcinoma | Hydrogen-Ion Concentration | Humans | Vacuolar Proton-Translocating ATPases | Protons | Membrane Transport Proteins | Mouth Neoplasms | Sodium-Bicarbonate SymportersResumen
Cancer cells overexpress proton exchangers at the plasma membrane in order acidify the extracellular matrix and maintain the optimal pH for sustaining cancer growth. Among the families of proton exchangers implicated in carcinogenesis, carbonic anhydrases (CAs), monocarboxylate transporters (MCTs), Na(+)/H(+) exchangers (NHEs), sodium bicarbonate cotransporters (NBCs), and vacuolar ATPases (V-ATPases) are highlighted. Considerable research has been carried out into the utility of the understanding of these machineries in the diagnosis and prognosis of several solid tumors. In addition, as therapeutic targets, the interference of their functions has contributed to the discovery or optimization of cancer therapies. According to recent reports, the study of these mechanisms seems promising in the particular case of oral squamous cell carcinoma (OSCC). In the present review, the latest advances in these fields are summarized, in particular, the usefulness of proton exchangers as potential prognostic biomarkers and therapeutic targets in OSCC.