Adiponectin accounts for gender differences in hepatocellular carcinoma incidence
![Thumbnail](/xmlui/themes/Mirage2//images/thumbnails/thumn_cientif.png)
Identificadores![](/xmlui/themes/Mirage2//images/despl_identif.png)
Identificadores
URI: http://hdl.handle.net/20.500.11940/15680
PMID: 30944152
DOI: 10.1084/jem.20181288
ISSN: 0022-1007
Visualización o descarga de ficheros![](/xmlui/themes/Mirage2//images/despl_contenidos.png)
Visualización o descarga de ficheros
Fecha de publicación
2019Título de revista
JOURNAL OF EXPERIMENTAL MEDICINE
Tipo de contenido
Artigo
DeCS
proteína cinasa activada por mitógenos 14 | animales | incidencia | tejido adiposo | cálculos biliares | carcinoma | adipocitos | hígado | proteina cinasas activadas por AMP | obesidad | adiponectina | humanos | estudios de cohortes | neoplasias hepáticas | ratonesMeSH
Adiponectin | Adipose Tissue | Carcinoma | Liver | Obesity | Mice | Adipocytes | Animals | Incidence | Gallstones | Humans | Mitogen-Activated Protein Kinase 14 | AMP-Activated Protein Kinases | Liver Neoplasms | Cohort StudiesResumen
Hepatocellular carcinoma (HCC) is the sixth most common cancer type and the fourth leading cause of cancer-related death. This cancer appears with higher incidence in men and during obesity; however, the specific mechanisms underlying this correlation are unknown. Adipose tissue, a key organ in metabolic syndrome, shows evident gender disparities in the production of adipokines. Levels of the important adipokine adiponectin decrease in men during puberty, as well as in the obese state. Here, we show that this decrease in adiponectin levels is responsible for the increased liver cancer risk in males. We found that testosterone activates the protein JNK in mouse and human adipocytes. JNK-mediated inhibition of adiponectin secretion increases liver cancer cell proliferation, since adiponectin protects against liver cancer development through the activation of AMP-activated protein kinase (AMPK) and p38alpha. This study provides insight into adipose tissue to liver crosstalk and its gender relation during cancer development, having the potential to guide strategies for new cancer therapeutics.
Excepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-ShareAlike 4.0 International
![](/xmlui/themes/Mirage2//images/final_lines.png)