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dc.contributor.authorRodger, A. J.
dc.contributor.authorCambiano, V.
dc.contributor.authorBruun, T.
dc.contributor.authorVernazza, P.
dc.contributor.authorCollins, S.
dc.contributor.authorDegen, O.
dc.contributor.authorCorbelli, G. M.
dc.contributor.authorEstrada, V.
dc.contributor.authorGeretti, A. M.
dc.contributor.authorBeloukas, A.
dc.contributor.authorRaben, D.
dc.contributor.authorColl, P.
dc.contributor.authorAntinori, A.
dc.contributor.authorNwokolo, N.
dc.contributor.authorRieger, A.
dc.contributor.authorPrins, J. M.
dc.contributor.authorBlaxhult, A.
dc.contributor.authorWeber, R.
dc.contributor.authorVan Eeden, A.
dc.contributor.authorBrockmeyer, N. H.
dc.contributor.authorClarke, A.
dc.contributor.authorGuerrero, J. D.
dc.contributor.authorRaffi, F.
dc.contributor.authorBogner, J. R.
dc.contributor.authorWandeler, G.
dc.contributor.authorGerstoft, J.
dc.contributor.authorGutierrez, F.
dc.contributor.authorBrinkman, K.
dc.contributor.authorKitchen, M.
dc.contributor.authorOstergaard, L.
dc.contributor.authorLeon, A.
dc.contributor.authorRistola, M.
dc.contributor.authorJessen, H.
dc.contributor.authorStellbrink, H. J.
dc.contributor.authorPhillips, A. N.
dc.contributor.authorLundgren, J.
dc.contributor.authorViciana, P.
dc.contributor.authorEspinosa, N.
dc.contributor.authorLopez-Cortes, L.
dc.contributor.authorMasia, M.
dc.contributor.authorRobledano, C.
dc.contributor.authorCobarsi, P.
dc.contributor.authorNieto, A.
dc.contributor.authorPodzamczer, D.
dc.contributor.authorTiraboschi, J.
dc.contributor.authorMorenilla, S.
dc.contributor.authorMeulbroek, M.
dc.contributor.authorCarrillo, A.
dc.contributor.authorSaz, J.
dc.contributor.authorMarquez, R.
dc.contributor.authorSandoval, R.
dc.contributor.authorAntela López, Antonio 
dc.contributor.authorLosada Arias, Elena 
dc.contributor.authorLeal, L.
dc.contributor.authorRedondo, E. G.
dc.contributor.authorGarcia, M. V.
dc.contributor.authorAsboe, D.
dc.contributor.authorFedele, S.
dc.contributor.authorSewell, J.
dc.contributor.authorGilson, R.
dc.contributor.authorGompels, M.
dc.contributor.authorJennings, L.
dc.contributor.authorWard, L.
dc.contributor.authorBrady, M.
dc.contributor.authorKirk, S.
dc.contributor.authorKnott, A.
dc.contributor.authorFox, J.
dc.contributor.authorLwanga, J.
dc.contributor.authorLee, M.
dc.contributor.authorLeen, C.
dc.contributor.authorMorris, S.
dc.contributor.authorClutterbuck, D.
dc.contributor.authorFidler, S.
dc.contributor.authorFernandez, T.
dc.contributor.authorBartel, S.
dc.contributor.authorHufner, A.
dc.contributor.authorKummerle, T.
dc.contributor.authorLehmann, C.
dc.contributor.authorBogner, J.
dc.contributor.authorSeybold, U.
dc.contributor.authorRoider, J.
dc.contributor.authorPotthoff, A.
dc.contributor.authorSkaletz-Rorowski, A.
dc.contributor.authorJessen, A.
dc.contributor.authorRuzicic, S.
dc.contributor.authorRockstroh, J.
dc.contributor.authorMohrmann, K.
dc.contributor.authorBoesecke, C.
dc.contributor.authorKrznaric, I.
dc.contributor.authorIngiliz, P.
dc.contributor.authorPrins, J.
dc.contributor.authorNobel, H. E.
dc.contributor.authorWeijsenfeld, A.
dc.contributor.authorVos, D.
dc.contributor.authorHoijenga, I.
dc.contributor.authorVerhagen, D.
dc.contributor.authorvan Eeden, A.
dc.contributor.authorElsenburg, L.
dc.contributor.authorGisolf, E.
dc.contributor.authorvan Bentum, P.
dc.contributor.authorGrube, C.
dc.contributor.authorBraun, D.
dc.contributor.authorFurrer, H.
dc.contributor.authorRauch, A.
dc.contributor.authorStoeckle, M.
dc.contributor.authorTarr, P.
dc.contributor.authorBattegay, M.
dc.contributor.authorSchmid, P.
dc.contributor.authorRasi, M.
dc.contributor.authorBernasconi, E.
dc.contributor.authorBernasconi, B.
dc.contributor.authorChristinet, V.
dc.contributor.authorJouinot, F.
dc.contributor.authorIsambert, C.
dc.contributor.authorBorso, D.
dc.contributor.authorStratmann, M.
dc.contributor.authorCaviezel, O.
dc.contributor.authorBini, T.
dc.contributor.authorMenichetti, S.
dc.contributor.authorCelesia, B. M.
dc.contributor.authorGussio, M.
dc.contributor.authorMussini, C.
dc.contributor.authorMeschiari, M.
dc.contributor.authorDi Biagio, A.
dc.contributor.authorTaramasso, L.
dc.contributor.authorTouzeau-Romer, V.
dc.contributor.authorSarcletti, M.
dc.contributor.authorGisinger, M.
dc.contributor.authorOelinger, A.
dc.contributor.authorGeit, M.
dc.contributor.authorJensen, L. P.
dc.contributor.authorBayer, A. A.
dc.contributor.authorHandberg, P.
dc.contributor.authorKronborg, G.
dc.contributor.authorPedersen, S. S.
dc.contributor.authorBulow, N.
dc.contributor.authorRamskover, B.
dc.contributor.authorPradier, C.
dc.contributor.authorBreaud, S.
dc.contributor.authorBillaud, E.
dc.contributor.authorOhayon, M.
dc.contributor.authorGosset, D.
dc.contributor.authorFior, A.
dc.contributor.authorPialoux, G.
dc.contributor.authorThibaut, P.
dc.contributor.authorChas, J.
dc.contributor.authorLeclercq, V.
dc.contributor.authorPechenot, V.
dc.contributor.authorCoquelin, V.
dc.contributor.authorWestling, K.
dc.contributor.authorFrisen, E. M.
dc.contributor.authorAsk, R.
dc.contributor.authorHildingsson-Lundh, B.
dc.contributor.authorDebnam, O.
dc.contributor.authorSutinen, J.
dc.contributor.authorDe Wit, S.
dc.contributor.authorNecsoi, C.
dc.contributor.authorVandekerckhove, L.
dc.contributor.authorGoffard, J. C.
dc.contributor.authorHenrard, S.
dc.contributor.authorJaneiro, N.
dc.contributor.authorCortney, G.
dc.contributor.authorO'Dea, S.
dc.date.accessioned2021-11-24T13:09:03Z
dc.date.available2021-11-24T13:09:03Z
dc.date.issued2019
dc.identifier.issn0140-6736
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31056293es]bi
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15733
dc.description.abstractBACKGROUND: The level of evidence for HIV transmission risk through condomless sex in serodifferent gay couples with the HIV-positive partner taking virally suppressive antiretroviral therapy (ART) is limited compared with the evidence available for transmission risk in heterosexual couples. The aim of the second phase of the PARTNER study (PARTNER2) was to provide precise estimates of transmission risk in gay serodifferent partnerships. METHODS: The PARTNER study was a prospective observational study done at 75 sites in 14 European countries. The first phase of the study (PARTNER1; Sept 15, 2010, to May 31, 2014) recruited and followed up both heterosexual and gay serodifferent couples (HIV-positive partner taking suppressive ART) who reported condomless sex, whereas the PARTNER2 extension (to April 30, 2018) recruited and followed up gay couples only. At study visits, data collection included sexual behaviour questionnaires, HIV testing (HIV-negative partner), and HIV-1 viral load testing (HIV-positive partner). If a seroconversion occurred in the HIV-negative partner, anonymised phylogenetic analysis was done to compare HIV-1 pol and env sequences in both partners to identify linked transmissions. Couple-years of follow-up were eligible for inclusion if condomless sex was reported, use of pre-exposure prophylaxis or post-exposure prophylaxis was not reported by the HIV-negative partner, and the HIV-positive partner was virally suppressed (plasma HIV-1 RNA <200 copies per mL) at the most recent visit (within the past year). Incidence rate of HIV transmission was calculated as the number of phylogenetically linked HIV infections that occurred during eligible couple-years of follow-up divided by eligible couple-years of follow-up. Two-sided 95% CIs for the incidence rate of transmission were calculated using exact Poisson methods. FINDINGS: Between Sept 15, 2010, and July 31, 2017, 972 gay couples were enrolled, of which 782 provided 1593 eligible couple-years of follow-up with a median follow-up of 2.0 years (IQR 1.1-3.5). At baseline, median age for HIV-positive partners was 40 years (IQR 33-46) and couples reported condomless sex for a median of 1.0 years (IQR 0.4-2.9). During eligible couple-years of follow-up, couples reported condomless anal sex a total of 76 088 times. 288 (37%) of 777 HIV-negative men reported condomless sex with other partners. 15 new HIV infections occurred during eligible couple-years of follow-up, but none were phylogenetically linked within-couple transmissions, resulting in an HIV transmission rate of zero (upper 95% CI 0.23 per 100 couple-years of follow-up). INTERPRETATION: Our results provide a similar level of evidence on viral suppression and HIV transmission risk for gay men to that previously generated for heterosexual couples and suggest that the risk of HIV transmission in gay couples through condomless sex when HIV viral load is suppressed is effectively zero. Our findings support the message of the U=U (undetectable equals untransmittable) campaign, and the benefits of early testing and treatment for HIV. FUNDING: National Institute for Health Research.en
dc.language.isoenges
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshCondoms *
dc.subject.meshAdult *
dc.subject.meshMiddle Aged *
dc.subject.meshHumans *
dc.subject.meshUnsafe Sex *
dc.subject.meshHomosexuality *
dc.subject.meshViral Load *
dc.subject.meshAnti-HIV Agents *
dc.subject.meshProspective Studies *
dc.subject.meshHIV Seropositivity *
dc.titleRisk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational studyen
dc.typeArtigoes
dc.contributor.authorcorpPartner Study Group
dc.authorsophosRodger, A. J.
dc.authorsophosCambiano, V.
dc.authorsophosBruun, T.
dc.authorsophosVernazza, P.
dc.authorsophosCollins, S.
dc.authorsophosDegen, O.
dc.authorsophosCorbelli, G. M.
dc.authorsophosEstrada, V.
dc.authorsophosGeretti, A. M.
dc.authorsophosBeloukas, A.
dc.authorsophosRaben, D.
dc.authorsophosColl, P.
dc.authorsophosAntinori, A.
dc.authorsophosNwokolo, N.
dc.authorsophosRieger, A.
dc.authorsophosPrins, J. M.
dc.authorsophosBlaxhult, A.
dc.authorsophosWeber, R.
dc.authorsophosVan Eeden, A.
dc.authorsophosBrockmeyer, N. H.
dc.authorsophosClarke, A.
dc.authorsophosGuerrero, J. D.
dc.authorsophosRaffi, F.
dc.authorsophosBogner, J. R.
dc.authorsophosWandeler, G.
dc.authorsophosGerstoft, J.
dc.authorsophosGutierrez, F.
dc.authorsophosBrinkman, K.
dc.authorsophosKitchen, M.
dc.authorsophosOstergaard, L.
dc.authorsophosLeon, A.
dc.authorsophosRistola, M.
dc.authorsophosJessen, H.
dc.authorsophosStellbrink, H. J.
dc.authorsophosPhillips, A. N.
dc.authorsophosLundgren, J.
dc.authorsophosViciana, P.
dc.authorsophosEspinosa, N.
dc.authorsophosLopez-Cortes, L.
dc.authorsophosMasia, M.
dc.authorsophosRobledano, C.
dc.authorsophosCobarsi, P.
dc.authorsophosNieto, A.
dc.authorsophosPodzamczer, D.
dc.authorsophosTiraboschi, J.
dc.authorsophosMorenilla, S.
dc.authorsophosMeulbroek, M.
dc.authorsophosCarrillo, A.
dc.authorsophosSaz, J.
dc.authorsophosMarquez, R.
dc.authorsophosSandoval, R.
dc.authorsophosAntela, A.
dc.authorsophosLosada, E.
dc.authorsophosLeal, L.
dc.authorsophosRedondo, E. G.
dc.authorsophosGarcia, M. V.
dc.authorsophosAsboe, D.
dc.authorsophosFedele, S.
dc.authorsophosSewell, J.
dc.authorsophosGilson, R.
dc.authorsophosGompels, M.
dc.authorsophosJennings, L.
dc.authorsophosWard, L.
dc.authorsophosBrady, M.
dc.authorsophosKirk, S.
dc.authorsophosKnott, A.
dc.authorsophosFox, J.
dc.authorsophosLwanga, J.
dc.authorsophosLee, M.
dc.authorsophosLeen, C.
dc.authorsophosMorris, S.
dc.authorsophosClutterbuck, D.
dc.authorsophosFidler, S.
dc.authorsophosFernandez, T.
dc.authorsophosBartel, S.
dc.authorsophosHufner, A.
dc.authorsophosKummerle, T.
dc.authorsophosLehmann, C.
dc.authorsophosBogner, J.
dc.authorsophosSeybold, U.
dc.authorsophosRoider, J.
dc.authorsophosPotthoff, A.
dc.authorsophosSkaletz-Rorowski, A.
dc.authorsophosJessen, A.
dc.authorsophosRuzicic, S.
dc.authorsophosRockstroh, J.
dc.authorsophosMohrmann, K.
dc.authorsophosBoesecke, C.
dc.authorsophosKrznaric, I.
dc.authorsophosIngiliz, P.
dc.authorsophosPrins, J.
dc.authorsophosNobel, H. E.
dc.authorsophosWeijsenfeld, A.
dc.authorsophosVos, D.
dc.authorsophosHoijenga, I.
dc.authorsophosVerhagen, D.
dc.authorsophosvan Eeden, A.
dc.authorsophosElsenburg, L.
dc.authorsophosGisolf, E.
dc.authorsophosvan Bentum, P.
dc.authorsophosGrube, C.
dc.authorsophosBraun, D.
dc.authorsophosFurrer, H.
dc.authorsophosRauch, A.
dc.authorsophosStoeckle, M.
dc.authorsophosTarr, P.
dc.authorsophosBattegay, M.
dc.authorsophosSchmid, P.
dc.authorsophosRasi, M.
dc.authorsophosBernasconi, E.
dc.authorsophosBernasconi, B.
dc.authorsophosChristinet, V.
dc.authorsophosJouinot, F.
dc.authorsophosIsambert, C.
dc.authorsophosBorso, D.
dc.authorsophosStratmann, M.
dc.authorsophosCaviezel, O.
dc.authorsophosBini, T.
dc.authorsophosMenichetti, S.
dc.authorsophosCelesia, B. M.
dc.authorsophosGussio, M.
dc.authorsophosMussini, C.
dc.authorsophosMeschiari, M.
dc.authorsophosDi Biagio, A.
dc.authorsophosTaramasso, L.
dc.authorsophosTouzeau-Romer, V.
dc.authorsophosSarcletti, M.
dc.authorsophosGisinger, M.
dc.authorsophosOelinger, A.
dc.authorsophosGeit, M.
dc.authorsophosJensen, L. P.
dc.authorsophosBayer, A. A.
dc.authorsophosHandberg, P.
dc.authorsophosKronborg, G.
dc.authorsophosPedersen, S. S.
dc.authorsophosBulow, N.
dc.authorsophosRamskover, B.
dc.authorsophosPradier, C.
dc.authorsophosBreaud, S.
dc.authorsophosBillaud, E.
dc.authorsophosOhayon, M.
dc.authorsophosGosset, D.
dc.authorsophosFior, A.
dc.authorsophosPialoux, G.
dc.authorsophosThibaut, P.
dc.authorsophosChas, J.
dc.authorsophosLeclercq, V.
dc.authorsophosPechenot, V.
dc.authorsophosCoquelin, V.
dc.authorsophosWestling, K.
dc.authorsophosFrisen, E. M.
dc.authorsophosAsk, R.
dc.authorsophosHildingsson-Lundh, B.
dc.authorsophosDebnam, O.
dc.authorsophosSutinen, J.
dc.authorsophosDe Wit, S.
dc.authorsophosNecsoi, C.
dc.authorsophosVandekerckhove, L.
dc.authorsophosGoffard, J. C.
dc.authorsophosHenrard, S.
dc.authorsophosJaneiro, N.
dc.authorsophosCortney, G.
dc.authorsophosO'Dea, S.
dc.authorsophosGrp, Partner Study
dc.identifier.doi10.1016/s0140-6736(19)30418-0
dc.identifier.pmid31056293
dc.identifier.sophos31447
dc.issue.number10189es
dc.journal.titleLANCETes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.page.initial2428es
dc.page.final2438es
dc.rights.accessRightsopenAccesses
dc.subject.decscondones *
dc.subject.decsestudios prospectivos *
dc.subject.decshomosexualidad *
dc.subject.decscarga viral *
dc.subject.decsrelaciones sexuales inseguras *
dc.subject.decsmediana edad *
dc.subject.decshumanos *
dc.subject.decsseropositividad al VIH *
dc.subject.decsfármacos anti-VIH *
dc.subject.decsadulto *
dc.subject.keywordCHUSes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number393es


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Attribution-NonCommercial-NoDerivatives 4.0 International
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