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dc.contributor.authorRoe, M. T.
dc.contributor.authorLi, Q. H.
dc.contributor.authorBhatt, D. L.
dc.contributor.authorBittner, V. A.
dc.contributor.authorDiaz, R.
dc.contributor.authorGoodman, S. G.
dc.contributor.authorHarrington, R. A.
dc.contributor.authorJukema, J. W.
dc.contributor.authorLopez-Jaramillo, P.
dc.contributor.authorLopes, R. D.
dc.contributor.authorLouie, M. J.
dc.contributor.authorMoriarty, P. M.
dc.contributor.authorSzarek, M.
dc.contributor.authorVogel, R.
dc.contributor.authorWhite, H. D.
dc.contributor.authorZeiher, A. M.
dc.contributor.authorBaccara-Dinet, M. T.
dc.contributor.authorSteg, P. G.
dc.contributor.authorSchwartz, G. G.
dc.contributor.authorIñiguez Romo, Andres 
dc.contributor.authorGonzález Juanatey, José Ramón 
dc.contributor.authorGonzález Juanatey, Carlos 
dc.date.accessioned2021-11-24T13:27:18Z
dc.date.available2021-11-24T13:27:18Z
dc.date.issued2019
dc.identifier.issn0009-7322
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31475572es]bi
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15734
dc.description.abstractBACKGROUND: The 2018 US cholesterol management guidelines recommend additional lipid-lowering therapies for secondary prevention in patients with low-density lipoprotein cholesterol >/=70 mg/dL or non-high-density lipoprotein cholesterol >/=100 mg/dL despite maximum tolerated statin therapy. Such patients are considered at very high risk (VHR) based on a history of >1 major atherosclerotic cardiovascular disease (ASCVD) event or a single ASCVD event and multiple high-risk conditions. We investigated the association of US guideline-defined risk categories with the occurrence of ischemic events after acute coronary syndrome and reduction of those events by alirocumab, a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor. METHODS: In the ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab), patients with recent acute coronary syndrome and residual dyslipidemia despite optimal statin therapy were randomly assigned to alirocumab or placebo. The primary trial outcome (major adverse cardiovascular events, ie, coronary heart disease death, nonfatal myocardial infarction, ischemic stroke, or hospitalization for unstable angina) was examined according to American College of Cardiology/American Heart Association risk category. RESULTS: Of 18 924 participants followed for a median of 2.8 years, 11 935 (63.1%) were classified as VHR: 4450 (37.3%) had multiple prior ASCVD events and 7485 (62.7%) had 1 major ASCVD event and multiple high-risk conditions. Major adverse cardiovascular events occurred in 14.4% of placebo-treated patients at VHR versus 5.6% of those not at VHR. In the VHR category, major adverse cardiovascular events occurred in 20.4% with multiple prior ASCVD events versus 10.7% with 1 ASCVD event and multiple high-risk conditions. Alirocumab was associated with consistent relative risk reductions in both risk categories (hazard ratio=0.84 for VHR; hazard ratio=0.86 for not VHR; Pinteraction=0.820) and by stratification within the VHR group (hazard ratio=0.86 for multiple prior ASCVD events; hazard ratio=0.82 for 1 major ASCVD event and multiple high-risk conditions; Pinteraction=0.672). The absolute risk reduction for major adverse cardiovascular events with alirocumab was numerically greater (but not statistically different) in the VHR group versus those not at VHR (2.1% versus 0.8%; Pinteraction=0.095) and among patients at VHR with multiple prior ASCVD events versus a single prior ASCVD event (2.4% versus 1.8%; Pinteraction=0.661). CONCLUSIONS: The US guideline criteria identify patients with recent acute coronary syndrome and dyslipidemia who are at VHR for recurrent ischemic events and who may derive a larger absolute benefit from treatment with alirocumab. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01663402.en
dc.language.isoenges
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshRisk Factors*
dc.subject.meshDyslipidemias*
dc.subject.meshRisk Assessment*
dc.subject.meshMiddle Aged*
dc.subject.meshHumans*
dc.subject.meshAntibodies*
dc.subject.meshTreatment Outcome*
dc.subject.meshCholesterol*
dc.subject.meshTime Factors*
dc.subject.meshRecurrence*
dc.subject.meshAcute Coronary Syndrome*
dc.subject.meshPractice Guidelines as Topic*
dc.subject.meshAnticholesteremic Agents*
dc.subject.meshAged*
dc.subject.meshSerine Proteinase Inhibitors*
dc.subject.meshSecondary Prevention*
dc.titleRisk Categorization Using New American College of Cardiology/American Heart Association Guidelines for Cholesterol Management and Its Relation to Alirocumab Treatment Following Acute Coronary Syndromesen
dc.typeArtigoes
dc.authorsophosRoe, M. T.
dc.authorsophosLi, Q. H.
dc.authorsophosBhatt, D. L.
dc.authorsophosBittner, V. A.
dc.authorsophosDiaz, R.
dc.authorsophosGoodman, S. G.
dc.authorsophosHarrington, R. A.
dc.authorsophosJukema, J. W.
dc.authorsophosLopez-Jaramillo, P.
dc.authorsophosLopes, R. D.
dc.authorsophosLouie, M. J.
dc.authorsophosMoriarty, P. M.
dc.authorsophosSzarek, M.
dc.authorsophosVogel, R.
dc.authorsophosWhite, H. D.
dc.authorsophosZeiher, A. M.
dc.authorsophosBaccara-Dinet, M. T.
dc.authorsophosSteg, P. G.
dc.authorsophosSchwartz, G. G.
dc.authorsophosTricoci, P.
dc.authorsophosMahaffey, K. W.
dc.authorsophosEdelberg, J. M.
dc.authorsophosHanotin, C.
dc.authorsophosLecorps, G.
dc.authorsophosMoryusef, A.
dc.authorsophosPordy, R.
dc.authorsophosSasiela, W. J.
dc.authorsophosTamby, J. F.
dc.authorsophosAylward, P. E.
dc.authorsophosDrexel, H.
dc.authorsophosSinnaeve, P.
dc.authorsophosDilic, M.
dc.authorsophosGotcheva, N. N.
dc.authorsophosPrieto, J. C.
dc.authorsophosYong, H.
dc.authorsophosPecin, I.
dc.authorsophosReiner, Z.
dc.authorsophosOstadal, P.
dc.authorsophosPoulsen, S. H.
dc.authorsophosViigimaa, M.
dc.authorsophosNieminen, M. S.
dc.authorsophosDanchin, N.
dc.authorsophosChumburidze, V.
dc.authorsophosMarx, N.
dc.authorsophosLiberopoulos, E.
dc.authorsophosValdovinos, P. C. M.
dc.authorsophosTse, H. F.
dc.authorsophosKiss, R. G.
dc.authorsophosXavier, D.
dc.authorsophosZahger, D.
dc.authorsophosValgimigli, M.
dc.authorsophosKimura, T.
dc.authorsophosKim, H. S.
dc.authorsophosKim, S. H.
dc.authorsophosKedev, S.
dc.authorsophosErglis, A.
dc.authorsophosLaucevicius, A.
dc.authorsophosYusoff, K.
dc.authorsophosLopez, R.
dc.authorsophosLopez, G. A. R.
dc.authorsophosAlings, M.
dc.authorsophosHalvorsen, S.
dc.authorsophosFlores, R. M. C.
dc.authorsophosSy, R. G.
dc.authorsophosBudaj, A.
dc.authorsophosMorais, J.
dc.authorsophosDorobantu, M.
dc.authorsophosKarpov, Y.
dc.authorsophosRistic, A. D.
dc.authorsophosChua, T.
dc.authorsophosMurin, J.
dc.authorsophosFras, Z.
dc.authorsophosDalby, A. J.
dc.authorsophosTunon, J.
dc.authorsophosDe Silva, H. A.
dc.authorsophosHagstrom, E.
dc.authorsophosMuller, C.
dc.authorsophosChiang, C. E.
dc.authorsophosSritara, P.
dc.authorsophosGuneri, S.
dc.authorsophosParkhomenko, A.
dc.authorsophosRay, K. K.
dc.authorsophosChaitman, B.
dc.authorsophosKelsey, S. F.
dc.authorsophosOlsson, A. G.
dc.authorsophosRouleau, J. L.
dc.authorsophosSimoons, M. L.
dc.authorsophosAlexander, K.
dc.authorsophosMeloni, C.
dc.authorsophosRosenson, R.
dc.authorsophosSijbrands, E. J. G.
dc.authorsophosAlexander, J. H.
dc.authorsophosArmaganijan, L.
dc.authorsophosBagai, A.
dc.authorsophosBahit, M. C.
dc.authorsophosBrennan, J. M.
dc.authorsophosClifton, S.
dc.authorsophosDeVore, A. D.
dc.authorsophosDeloatch, S.
dc.authorsophosDickey, S.
dc.authorsophosDombrowski, K.
dc.authorsophosDucrocq, G.
dc.authorsophosEapen, Z.
dc.authorsophosEndsley, P.
dc.authorsophosEppinger, A.
dc.authorsophosHarrison, R. W.
dc.authorsophosHess, C. N.
dc.authorsophosHlatky, M. A.
dc.authorsophosJordan, J. D.
dc.authorsophosKnowles, J. W.
dc.authorsophosKolls, B. J.
dc.authorsophosKong, D. F.
dc.authorsophosLeonardi, S.
dc.authorsophosLillis, L.
dc.authorsophosMaron, D. J.
dc.authorsophosMarcus, J.
dc.authorsophosMathews, R.
dc.authorsophosMehta, R. H.
dc.authorsophosMentz, R. J.
dc.authorsophosMoreira, H. G.
dc.authorsophosPatel, C. B.
dc.authorsophosPereira, S. B.
dc.authorsophosPerkins, L.
dc.authorsophosPovsic, T. J.
dc.authorsophosPuymirat, E.
dc.authorsophosJones, W. S.
dc.authorsophosShah, B. R.
dc.authorsophosSherwood, M. W.
dc.authorsophosStringfellow, K.
dc.authorsophosSujjavanich, D.
dc.authorsophosToma, M.
dc.authorsophosVan Diepen, S. F. P.
dc.authorsophosWilson, M. D.
dc.authorsophosYan, A. T. K.
dc.authorsophosTrotter, C.
dc.authorsophosSchiavi, L. B.
dc.authorsophosGarrido, M.
dc.authorsophosAlvarisqueta, A. F.
dc.authorsophosSassone, S. A.
dc.authorsophosBordonava, A. P.
dc.authorsophosDe Lima, A. E. A.
dc.authorsophosSchmidberg, J. M.
dc.authorsophosDuronto, E. A.
dc.authorsophosCaruso, O. C.
dc.authorsophosNovaretto, L. P.
dc.authorsophosHominal, M. A.
dc.authorsophosMontana, O. R.
dc.authorsophosCaccavo, A.
dc.authorsophosVilamajo, O. A. G.
dc.authorsophosLorenzatti, A. J.
dc.authorsophosCartasegna, L. R.
dc.authorsophosPaterlini, G. A.
dc.authorsophosMackinnon, I. J.
dc.authorsophosCaime, G. D.
dc.authorsophosAmuchastegui, M.
dc.authorsophosSalomone, R.
dc.authorsophosCodutti, O. R.
dc.authorsophosJure, H. O.
dc.authorsophosBono, J. O. E.
dc.authorsophosHrabar, A. D.
dc.authorsophosVallejos, J. A.
dc.authorsophosGuerrero, R. A. A.
dc.authorsophosNovoa, F.
dc.authorsophosPatocchi, C. A.
dc.authorsophosZaidman, C. J.
dc.authorsophosGiuliano, M. E.
dc.authorsophosDran, R. D.
dc.authorsophosVico, M. L.
dc.authorsophosCarnero, G. S.
dc.authorsophosGuzman, P. N.
dc.authorsophosAllende, J. C. M.
dc.authorsophosBrasca, D. F. G.
dc.authorsophosLabarta, M. H. B.
dc.authorsophosNani, S.
dc.authorsophosBlumberg, E. D. S.
dc.authorsophosColombo, H. R.
dc.authorsophosLiberman, A.
dc.authorsophosLuciardi, H. L.
dc.authorsophosWaisman, G. D.
dc.authorsophosBerli, M. A.
dc.authorsophosDuran, R. O. G.
dc.authorsophosCestari, H. G.
dc.authorsophosLuquez, H. A.
dc.authorsophosGiordano, J. A.
dc.authorsophosSaavedra, S. S.
dc.authorsophosZapata, G.
dc.authorsophosCostamagna, O.
dc.authorsophosLlois, S.
dc.authorsophosWaites, J. H.
dc.authorsophosCollins, N.
dc.authorsophosSoward, A.
dc.authorsophosHii, C. L. S.
dc.authorsophosShaw, J.
dc.authorsophosArstall, M. A.
dc.authorsophosHorowitz, J.
dc.authorsophosRogers, J. F.
dc.authorsophosColquhoun, D.
dc.authorsophosFlores, R. E. O.
dc.authorsophosRoberts-Thomson, P.
dc.authorsophosRaffel, O.
dc.authorsophosLehman, S. J.
dc.authorsophosAroney, C.
dc.authorsophosCoverdale, S. G. M.
dc.authorsophosGarrahy, P. J.
dc.authorsophosStarmer, G.
dc.authorsophosSader, M.
dc.authorsophosCarroll, P. A.
dc.authorsophosDick, R.
dc.authorsophosZweiker, R.
dc.authorsophosHoppe, U.
dc.authorsophosHuber, K.
dc.authorsophosBerger, R.
dc.authorsophosWeidinger, F.
dc.authorsophosFaes, D.
dc.authorsophosHermans, K.
dc.authorsophosPirenne, B.
dc.authorsophosLeone, A.
dc.authorsophosHoffer, E.
dc.authorsophosVrolix, M. C. M.
dc.authorsophosDe Wolf, L.
dc.authorsophosWollaert, B.
dc.authorsophosCastadot, M.
dc.authorsophosDujardin, K.
dc.authorsophosBeauloye, C.
dc.authorsophosVervoort, G.
dc.authorsophosStriekwold, H.
dc.authorsophosConvens, C.
dc.authorsophosRoosen, J.
dc.authorsophosBarbato, E.
dc.authorsophosClaeys, M.
dc.authorsophosCools, F.
dc.authorsophosTerzic, I.
dc.authorsophosBarakovic, F.
dc.authorsophosMidzic, Z.
dc.authorsophosPojskic, B.
dc.authorsophosFazlibegovic, E.
dc.authorsophosDurak-Nalbantic, A.
dc.authorsophosVulic, D.
dc.authorsophosMuslibegovic, A.
dc.authorsophosGoronja, B.
dc.authorsophosReis, G.
dc.authorsophosSousa, L.
dc.authorsophosNicolau, J. C.
dc.authorsophosGiorgeto, F. E.
dc.authorsophosSilva, R. P.
dc.authorsophosMaia, L. N.
dc.authorsophosRech, R.
dc.authorsophosRossi, P. R. F.
dc.authorsophosCerqueira, Mjag
dc.authorsophosDuda, N.
dc.authorsophosKalil, R.
dc.authorsophosKormann, A.
dc.authorsophosAbrantes, J. A. M.
dc.authorsophosPimentel, P.
dc.authorsophosSoggia, A. P.
dc.authorsophosde Santos, M. O. N.
dc.authorsophosNeuenschwander, F.
dc.authorsophosBodanese, L. C.
dc.authorsophosMichalaros, Y. L.
dc.authorsophosEliaschewitz, F. G.
dc.authorsophosVidotti, M. H.
dc.authorsophosLeaes, P. E.
dc.authorsophosBotelho, R. V.
dc.authorsophosKaiser, S.
dc.authorsophosManenti, Erff
dc.authorsophosPrecoma, D. B.
dc.authorsophosJorge, J. C. M.
dc.authorsophosSilva, Pgmd
dc.authorsophosSilveira, J. A.
dc.authorsophosSaporito, W.
dc.authorsophosMarin, J. A.
dc.authorsophosFeitosa, G. S.
dc.authorsophosRitt, L. E. F.
dc.authorsophosde Souza, J. A.
dc.authorsophosCosta, F.
dc.authorsophosSouza, Wksb
dc.authorsophosReis, H. J. L.
dc.authorsophosMachado, L.
dc.authorsophosAyoub, J. C. A.
dc.authorsophosTodorov, G. V.
dc.authorsophosNikolov, F. P.
dc.authorsophosVelcheva, E. S.
dc.authorsophosTzekova, M. L.
dc.authorsophosBenov, H. O.
dc.authorsophosPetranov, S. L.
dc.authorsophosTumbev, H. S.
dc.authorsophosShehova-Yankova, N. S.
dc.authorsophosMarkov, D. T.
dc.authorsophosRaev, D. H.
dc.authorsophosMollov, M. N.
dc.authorsophosKichukov, K. N.
dc.authorsophosIlieva-Pandeva, K. A.
dc.authorsophosIvanova, R.
dc.authorsophosMincheva, V. M.
dc.authorsophosLazov, P. V.
dc.authorsophosDimov, B. I.
dc.authorsophosSenaratne, M.
dc.authorsophosStone, J.
dc.authorsophosKornder, J.
dc.authorsophosPearce, S.
dc.authorsophosDion, D.
dc.authorsophosSavard, D.
dc.authorsophosPesant, Y.
dc.authorsophosPandey, A.
dc.authorsophosRobinson, S.
dc.authorsophosGosselin, G.
dc.authorsophosVizel, S.
dc.authorsophosHoag, G.
dc.authorsophosBourgeois, R.
dc.authorsophosMorisset, A.
dc.authorsophosSabbah, E.
dc.authorsophosSussex, B.
dc.authorsophosKouz, S.
dc.authorsophosMacDonald, P.
dc.authorsophosDiaz, A.
dc.authorsophosMichaud, N.
dc.authorsophosFell, D.
dc.authorsophosLeung, R.
dc.authorsophosVuurmans, T.
dc.authorsophosLai, C.
dc.authorsophosNigro, F.
dc.authorsophosDavies, R.
dc.authorsophosNogareda, G.
dc.authorsophosVijayaraghavan, R.
dc.authorsophosDucas, J.
dc.authorsophosLepage, S.
dc.authorsophosMehta, S.
dc.authorsophosCha, J.
dc.authorsophosDupuis, R.
dc.authorsophosFong, P.
dc.authorsophosRodes-Cabau, J.
dc.authorsophosFadlallah, H.
dc.authorsophosCleveland, D.
dc.authorsophosHuynh, T.
dc.authorsophosBata, I.
dc.authorsophosHameed, A.
dc.authorsophosPincetti, C.
dc.authorsophosPotthoff, S.
dc.authorsophosAcevedo, M.
dc.authorsophosAguirre, A.
dc.authorsophosVejar, M.
dc.authorsophosYanez, M.
dc.authorsophosAraneda, G.
dc.authorsophosFernandez, M.
dc.authorsophosPerez, L.
dc.authorsophosVarleta, P.
dc.authorsophosFlorenzano, F.
dc.authorsophosHuidobro, L.
dc.authorsophosRaffo, C. A.
dc.authorsophosOlivares, C.
dc.authorsophosNahuelpan, L.
dc.authorsophosMontecinos, H.
dc.authorsophosChen, J. Y.
dc.authorsophosDong, Y. G.
dc.authorsophosHuang, W. J.
dc.authorsophosWang, J. Z.
dc.authorsophosHuang, S. A.
dc.authorsophosYao, Z. H.
dc.authorsophosLi, X.
dc.authorsophosCui, L.
dc.authorsophosLin, W. H.
dc.authorsophosSun, Y. M.
dc.authorsophosWang, J. F.
dc.authorsophosLi, J. P.
dc.authorsophosZhang, X. L.
dc.authorsophosZhu, H.
dc.authorsophosChen, D.
dc.authorsophosHuang, L.
dc.authorsophosDong, S. H.
dc.authorsophosSu, G. H.
dc.authorsophosXu, B. A.
dc.authorsophosSu, X.
dc.authorsophosCheng, X. S.
dc.authorsophosLin, J. X.
dc.authorsophosZong, W. X.
dc.authorsophosLi, H. M.
dc.authorsophosFeng, Y.
dc.authorsophosXu, D. L.
dc.authorsophosYang, X. C.
dc.authorsophosKe, Y. N.
dc.authorsophosLin, X. F.
dc.authorsophosZhang, Z.
dc.authorsophosZheng, Z. Q.
dc.authorsophosLuo, Z. R.
dc.authorsophosChen, Y. D.
dc.authorsophosDing, C. H.
dc.authorsophosZheng, Y.
dc.authorsophosLi, X. D.
dc.authorsophosPeng, D. Q.
dc.authorsophosLi, Y.
dc.authorsophosWei, M.
dc.authorsophosLiu, S. W.
dc.authorsophosYu, Y. H.
dc.authorsophosQu, B. M.
dc.authorsophosJiang, W. H.
dc.authorsophosZhou, Y. J.
dc.authorsophosZhao, X. S.
dc.authorsophosYuan, Z. Y.
dc.authorsophosGuo, Y.
dc.authorsophosXu, X. P.
dc.authorsophosShi, X. B.
dc.authorsophosGe, J. B.
dc.authorsophosFu, G. S.
dc.authorsophosBai, F.
dc.authorsophosFang, W. Y.
dc.authorsophosShou, X. L.
dc.authorsophosYang, X. J.
dc.authorsophosWang, J. A.
dc.authorsophosSun, Y. X.
dc.authorsophosLu, Q. H.
dc.authorsophosZhang, R. Y.
dc.authorsophosZhu, J. H.
dc.authorsophosXu, Y. Z.
dc.authorsophosFan, Z. C.
dc.authorsophosLi, T. C.
dc.authorsophosWu, C.
dc.authorsophosJaramillo, N.
dc.authorsophosVallejo, G. S.
dc.authorsophosBotia, D. C. L.
dc.authorsophosLopez, R. B.
dc.authorsophosDe Salazar, D. I. M.
dc.authorsophosBonfanti, A. J. C.
dc.authorsophosHiguera, J. D.
dc.authorsophosSilva, S. I. B.
dc.authorsophosLozada, H. J. G.
dc.authorsophosArroyo, J. A. C.
dc.authorsophosMendoza, J. L. A.
dc.authorsophosRuiz, R. L. F.
dc.authorsophosJatin, F. G. M.
dc.authorsophosHerazo, A. S.
dc.authorsophosParada, J. C.
dc.authorsophosTriana, M. A. U.
dc.authorsophosStrozzi, M.
dc.authorsophosCar, S.
dc.authorsophosMilicic, D.
dc.authorsophosBencic, M. L.
dc.authorsophosPintaric, H.
dc.authorsophosPrvulovic, D.
dc.authorsophosSikic, J.
dc.authorsophosPersic, V.
dc.authorsophosMileta, D.
dc.authorsophosStambuk, K.
dc.authorsophosZdravko, B.
dc.authorsophosTomulic, V.
dc.authorsophosKrstulovic, S. M.
dc.authorsophosStarcevic, B.
dc.authorsophosSpinar, J.
dc.authorsophosHorak, D.
dc.authorsophosStasek, J.
dc.authorsophosAlan, D.
dc.authorsophosMachova, V.
dc.authorsophosLinhart, A.
dc.authorsophosNovotny, V.
dc.authorsophosKaucak, V.
dc.authorsophosRokyta, R.
dc.authorsophosNaplava, R.
dc.authorsophosCoufal, Z.
dc.authorsophosAdamkova, V.
dc.authorsophosPodpera, I.
dc.authorsophosZizka, J.
dc.authorsophosMotovska, Z.
dc.authorsophosMarusincova, I.
dc.authorsophosSvab, P.
dc.authorsophosHeinc, P.
dc.authorsophosKuchar, J.
dc.authorsophosPovolny, P.
dc.authorsophosMatuska, J.
dc.authorsophosRaungaard, B.
dc.authorsophosClemmensen, P.
dc.authorsophosBang, L. E.
dc.authorsophosMay, O.
dc.authorsophosBottcher, M.
dc.authorsophosHove, J. D.
dc.authorsophosFrost, L.
dc.authorsophosGislason, G.
dc.authorsophosLarsen, J.
dc.authorsophosJohansen, P. B.
dc.authorsophosHald, F.
dc.authorsophosJeppesen, J.
dc.authorsophosNielsen, T.
dc.authorsophosKristensen, K. S.
dc.authorsophosWalichiewicz, P. M.
dc.authorsophosLomholdt, J. D.
dc.authorsophosKlausen, I. C.
dc.authorsophosNielsen, P. K.
dc.authorsophosDavidsen, F.
dc.authorsophosVidebaek, L.
dc.authorsophosSoots, M.
dc.authorsophosVahula, V.
dc.authorsophosHedman, A.
dc.authorsophosSoopold, U.
dc.authorsophosMartsin, K.
dc.authorsophosKristjan, A.
dc.authorsophosTaskinen, M. R.
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dc.authorsophosSheller, J.
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dc.authorsophosPellan, V.
dc.authorsophosBenbernou, F.
dc.authorsophosBengrait, N.
dc.authorsophosLamoureux, M.
dc.authorsophosKralova, K.
dc.authorsophosScemama, M.
dc.authorsophosBejuit, R.
dc.authorsophosCoulange, A.
dc.authorsophosBerthou, C.
dc.authorsophosRepincay, J.
dc.authorsophosLorenzato, C.
dc.authorsophosEtienne, A.
dc.authorsophosGouet, V.
dc.authorsophosLoizeau, V.
dc.authorsophosNormand, M.
dc.authorsophosOurliac, A.
dc.authorsophosRondel, C.
dc.authorsophosAdamo, A.
dc.authorsophosBeltran, P.
dc.authorsophosBarraud, P.
dc.authorsophosDubois-Gache, H.
dc.authorsophosHalle, B.
dc.authorsophosMetwally, L.
dc.authorsophosMourgues, M.
dc.authorsophosSotty, M.
dc.authorsophosVincendet, M.
dc.authorsophosCotruta, R.
dc.authorsophosZhu, C. Y.
dc.authorsophosFournie-Lloret, D.
dc.authorsophosMorrello, C.
dc.authorsophosPerthuis, A.
dc.authorsophosPicault, P.
dc.authorsophosZobouyan, I.
dc.authorsophosInvestigators, Odyssey Outcomes
dc.identifier.doi10.1161/circulationaha.119.042551
dc.identifier.pmid31475572
dc.identifier.sophos31469
dc.issue.number19es
dc.journal.titleCirculationes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Cardioloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Cardioloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Lugo, Cervo e Monforte de lemos - Complexo Hospitalario Universitario Lucus Augusti::Cardioloxíaes
dc.page.initial1578es
dc.page.final1589es
dc.relation.publisherversionhttps://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.119.042551?download=truees
dc.rights.accessRightsopenAccesses
dc.subject.decsresultado del tratamiento*
dc.subject.decsfactores de riesgo*
dc.subject.decsprevención secundaria*
dc.subject.decsanticolesterolemiantes*
dc.subject.decsdislipidemias*
dc.subject.decsmediana edad*
dc.subject.decsanticuerpos*
dc.subject.decsguías de práctica clínica como asunto*
dc.subject.decssíndrome coronario agudo*
dc.subject.decsinhibidores de serina proteinasas*
dc.subject.decsanciano*
dc.subject.decsrecurrencia*
dc.subject.decshumanos*
dc.subject.decsevaluación de riesgos*
dc.subject.decsfactores de tiempo*
dc.subject.decscolesterol*
dc.subject.keywordCHUSes
dc.subject.keywordCHUVIes
dc.subject.keywordHULAes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number140es


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