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Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke

Torres-Aguila, N. P.; Carrera, C.; Giese, A. K.; Cullell, N.; Muino, E.; Carcel-Marquez, J.; Gallego-Fabrega, C.; Gonzalez-Sanchez, J.; Freijo, M. D.; Alvarez-Sabin, J.; Molina, C.; Ribo, M.; Jimenez-Conde, J.; Roquer, J.; Sobrino Moreiras, Tomas; Campos Pérez, Francisco; Castillo Sánchez, José; Munoz-Narbona, L.; Lopez-Cancio, E.; Davalos, A.; Diaz-Navarro, R.; Tur, S.; Vives-Bauza, C.; Serrano-Heras, G.; Segura, T.; Krupinski, J.; Delgado-Mederos, R.; Marti-Fabregas, J.; Heitsch, L.; Ibanez, L.; Cruchaga, C.; Rost, N. S.; Montaner, J.; Lee, J. M.; Fernandez-Cadenas, I.
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URI: http://hdl.handle.net/20.500.11940/15742
PMID: 31587654
DOI: 10.1161/strokeaha.119.026593
ISSN: 0039-2499
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Stroke. 2019 Dec;50(12):3618-3621. (356.3Kb)
Acceso a la versión del editor (121.3Kb)
Fecha de publicación
2019
Título de revista
Stroke
Tipo de contenido
Artigo
DeCS
recuento de leucocitos | pronóstico | anciano | cromosomas | isquemia cerebral | mediana edad | accidente cerebrovascular | humanos | estudio de asociación genómica completa | leucocitos
MeSH
Leukocyte Count | Middle Aged | Humans | Leukocytes | Genome-Wide Association Study | Chromosomes | Brain Ischemia | Stroke | Aged | Prognosis
Resumen
Background and Purpose- Immune cells play a key role in the first 24h poststroke (acute phase), being associated with stroke outcome. We aimed to find genetic risk factors associated with leukocyte counts during the acute phase of stroke. Methods- Ischemic stroke patients with leukocyte counts data during the first 24h were included. Genome-wide association study and gene expression studies were performed. Results- Our genome-wide association study, which included 2064 (Discovery) and 407 (Replication) patients, revealed a new locus (14q24.3) associated with leukocyte counts. After Joint analysis (n=2471) 5 more polymorphisms reached genome-wide significance (P<5x10(-8)). The 14q24.3 locus was associated with acute stroke outcome (rs112809786, P=0.036) and with ACOT1 and PTGR2 gene expression. Previous polymorphisms associated with leukocyte counts in general-population did not show any significance in our study. Conclusions- We have found the first locus associated with leukocyte counts in ischemic stroke, also associated with acute outcome. Genetic analysis of acute endophenotypes could be useful to find the genetic factors associated with stroke outcome. Our findings suggested a different modulation of immune cells in stroke compared with healthy conditions.

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