Show simple item record

dc.contributor.authorVázquez Ríos, Abi Judith
dc.contributor.authorMolina-Crespo, A.
dc.contributor.authorLópez Bouzo, Belén
dc.contributor.authorLópez López, Rafael 
dc.contributor.authorMoreno-Bueno, G.
dc.contributor.authorDe La Fuente Freire, María 
dc.date.accessioned2021-11-25T07:52:59Z
dc.date.available2021-11-25T07:52:59Z
dc.date.issued2019
dc.identifier.issn1477-3155
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31319859es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15746
dc.description.abstractBACKGROUND: Lack of effective tumor-specific delivery systems remains an unmet clinical challenge for successful translation of innovative therapies, such as, therapeutic oligonucleotides. In the past decade, exosomes have been suggested to be ideal drug delivery systems with application in a broad range of pathologies including cancer, due to their organotropic properties. Tumor-derived exosomes, having tumor-homing properties, can efficiently reach cancer cells and therefore behave as carriers for improved drug delivery to the primary tumor and metastases. However, due to their complex composition, and still undefined biological functions, safety concerns arise hampering their translation to the clinics. RESULTS: We propose here the development of exosome-mimetic nanosystems (EMNs) that simulate natural tumor-derived exosomes with respect to their structure and functionality, but with a controlled composition, for the targeted delivery of therapeutic oligonucleotides to lung adenocarcinoma cells (microRNA-145 mimics). Making use of the well-known liposome technology, EMNs can be engineered, loaded with the therapeutic compounds, and tailored with specific proteins (integrin alpha6beta4) providing them organotropic properties. EMNs show great similarities to natural exosomes with respect to their physicochemical properties, drug loading capacity, and ability to interact with the cancer target cells in vitro and in vivo, but are easier to manufacture, can be produced at high yields, and are safer by definition. CONCLUSIONS: We have designed a multifunctional nanoplatform mimicking exosomes, EMNs, and proved their potential to reach cancer cells with a similar efficient that tumor-derived exosomes but providing important advantages in terms of production methodology and regulations. Additionally, EMNs are highly versatile systems that can be tunable for a broader range of applications.en
dc.language.isoenges
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshBiomimetics *
dc.subject.meshIntegrins *
dc.subject.meshDrug Delivery Systems *
dc.subject.meshMice *
dc.subject.meshAnimals *
dc.subject.meshGene Transfer Techniques *
dc.subject.meshNanocapsules *
dc.subject.meshCell Survival *
dc.subject.meshAntineoplastic Agents *
dc.subject.meshSurface Properties *
dc.subject.meshCell Line *
dc.subject.meshMicroRNAs *
dc.subject.meshHumans *
dc.subject.meshExosomes *
dc.titleExosome-mimetic nanoplatforms for targeted cancer drug deliveryen
dc.typeArtigoes
dc.authorsophosVazquez-Rios, A. J.
dc.authorsophosMolina-Crespo, A.
dc.authorsophosBouzo, B. L.
dc.authorsophosLopez-Lopez, R.
dc.authorsophosMoreno-Bueno, G.
dc.authorsophosde la Fuente, M.
dc.identifier.doi10.1186/s12951-019-0517-8
dc.identifier.pmid31319859
dc.identifier.sophos31556
dc.journal.titleJournal of Nanobiotechnologyes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Oncoloxía médicaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.rights.accessRightsopenAccesses
dc.subject.decsbiomimética *
dc.subject.decsanimales *
dc.subject.decstécnicas de transferencia génica *
dc.subject.decsintegrinas *
dc.subject.decspropiedades de superficie *
dc.subject.decsantineoplásicos *
dc.subject.decsmicroARN *
dc.subject.decssupervivencia celular *
dc.subject.decsnanocápsulas *
dc.subject.decslínea celular *
dc.subject.decssistemas de liberación de medicamentos *
dc.subject.decshumanos *
dc.subject.decsexosomas *
dc.subject.decsratones *
dc.subject.keywordCHUSes
dc.subject.keywordIDISes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number17es


Files in this item

This item appears in the following Collection(s)

Show simple item record

Atribución 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución 4.0 Internacional