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dc.contributor.authorShu, X.
dc.contributor.authorWu, L.
dc.contributor.authorKhankari, N. K.
dc.contributor.authorShu, X. O.
dc.contributor.authorWang, T. J.
dc.contributor.authorMichailidou, K.
dc.contributor.authorBolla, M. K.
dc.contributor.authorWang, Q.
dc.contributor.authorDennis, J.
dc.contributor.authorMilne, R. L.
dc.contributor.authorSchmidt, M. K.
dc.contributor.authorPharoah, P. D. P.
dc.contributor.authorAndrulis, I. L.
dc.contributor.authorHunter, D. J.
dc.contributor.authorSimard, J.
dc.contributor.authorEaston, D. F.
dc.contributor.authorZheng, W.
dc.contributor.authorAlicia, B. F. J.
dc.contributor.authorAnton-Culver, H.
dc.contributor.authorAntonenkova, N. N.
dc.contributor.authorArndt, V.
dc.contributor.authorAronson, K. J.
dc.contributor.authorAuer, P. L.
dc.contributor.authorBarrdahl, M.
dc.contributor.authorBaynes, C.
dc.contributor.authorFreeman, L. E. B.
dc.contributor.authorBeckmann, M. W.
dc.contributor.authorBehrens, S.
dc.contributor.authorBenitez, J.
dc.contributor.authorBermisheva, M.
dc.contributor.authorBlomqvist, C.
dc.contributor.authorBogdanova, N. V.
dc.contributor.authorBojesen, S. E.
dc.contributor.authorBrauch, H.
dc.contributor.authorBrenner, H.
dc.contributor.authorBrinton, L.
dc.contributor.authorBroberg, P.
dc.contributor.authorBrucker, S. Y.
dc.contributor.authorBruning, T.
dc.contributor.authorBurwinkel, B.
dc.contributor.authorCai, Q. Y.
dc.contributor.authorCaldes, T.
dc.contributor.authorCanzian, F.
dc.contributor.authorCarter, B. D.
dc.contributor.authorCastelao, J. E.
dc.contributor.authorChang-Claude, J.
dc.contributor.authorChenevix-Trench, G.
dc.contributor.authorCheng, T. Y. D.
dc.contributor.authorClarke, C. L.
dc.contributor.authorConroy, D. M.
dc.contributor.authorCouch, F. J.
dc.contributor.authorCox, D. G.
dc.contributor.authorCox, A.
dc.contributor.authorCross, S. S.
dc.contributor.authorCunningham, J. M.
dc.contributor.authorCzene, K.
dc.contributor.authorDaly, M. B.
dc.contributor.authorDoheny, K. F.
dc.contributor.authorDork, T.
dc.contributor.authordos-Santos-Silva, I.
dc.contributor.authorDumont, M.
dc.contributor.authorDunning, A. M.
dc.contributor.authorDwek, M.
dc.contributor.authorEarp, H. S.
dc.contributor.authorEccles, D. M.
dc.contributor.authorEliassen, A. H.
dc.contributor.authorEngel, C.
dc.contributor.authorEriksson, M.
dc.contributor.authorEvans, D. G.
dc.contributor.authorFachal, L.
dc.contributor.authorFasching, P. A.
dc.contributor.authorFigueroa, J.
dc.contributor.authorFletcher, O.
dc.contributor.authorFlyger, H.
dc.contributor.authorFritschi, L.
dc.contributor.authorGabrielson, M.
dc.contributor.authorGago Dominguez, Manuela
dc.contributor.authorGapstur, S. M.
dc.contributor.authorGarcia-Closas, M.
dc.contributor.authorGaudet, M. M.
dc.contributor.authorGhoussaini, M.
dc.contributor.authorGiles, G. G.
dc.contributor.authorGoldberg, M. S.
dc.contributor.authorGoldgar, D. E.
dc.contributor.authorGonzalez-Neira, A.
dc.contributor.authorGuenel, P.
dc.contributor.authorHahnen, E.
dc.contributor.authorHaiman, C. A.
dc.contributor.authorHakansson, N.
dc.contributor.authorHall, P.
dc.contributor.authorHallberg, E.
dc.contributor.authorHamann, U.
dc.contributor.authorHarrington, P.
dc.contributor.authorHe, W.
dc.contributor.authorHein, A.
dc.contributor.authorHicks, B.
dc.contributor.authorHillemanns, P.
dc.contributor.authorHogervorst, F. B.
dc.contributor.authorHollestelle, A.
dc.contributor.authorHoover, R. N.
dc.contributor.authorHopper, J. L.
dc.contributor.authorHowell, A.
dc.contributor.authorHuang, G.
dc.contributor.authorJakubowska, A.
dc.contributor.authorJanni, W.
dc.contributor.authorJohn, E. M.
dc.contributor.authorJohnson, N.
dc.contributor.authorJones, K.
dc.contributor.authorJung, A.
dc.contributor.authorKaaks, R.
dc.contributor.authorKabisch, M.
dc.contributor.authorKerin, M. J.
dc.contributor.authorKhusnutdinova, E.
dc.contributor.authorKitahara, C. M.
dc.contributor.authorKosma, V. M.
dc.contributor.authorKoutros, S.
dc.contributor.authorKraft, P.
dc.contributor.authorKristensen, V. N.
dc.contributor.authorLambrechts, D.
dc.contributor.authorLe Marchand, L.
dc.contributor.authorLindstrom, S.
dc.contributor.authorLinet, M. S.
dc.contributor.authorLissowska, J.
dc.contributor.authorLoibl, S.
dc.contributor.authorLubinski, J.
dc.contributor.authorLuccarini, C.
dc.contributor.authorLux, M. P.
dc.contributor.authorMaishman, T.
dc.contributor.authorKostovska, I. M.
dc.contributor.authorMannermaa, A.
dc.contributor.authorManoukian, S.
dc.contributor.authorManson, J. E.
dc.contributor.authorMargolin, S.
dc.contributor.authorMavroudis, D.
dc.contributor.authorMeijers-Heijboer, H.
dc.contributor.authorMeindl, A.
dc.contributor.authorMenon, U.
dc.contributor.authorMeyer, J.
dc.contributor.authorMulligan, A. M.
dc.contributor.authorNeuhausen, S. L.
dc.contributor.authorNevanlinna, H.
dc.contributor.authorNeven, P.
dc.contributor.authorNewman, W. T.
dc.contributor.authorNielsen, S. F.
dc.contributor.authorNordestgaard, B. G.
dc.contributor.authorOlopade, O. I.
dc.contributor.authorOlshan, A. F.
dc.contributor.authorOlson, J. E.
dc.contributor.authorOlsson, H.
dc.contributor.authorOlswol, C.
dc.contributor.authorOrr, N.
dc.contributor.authorPerou, C. M.
dc.contributor.authorPeto, J.
dc.contributor.authorPlaseska-Karanfilska, D.
dc.contributor.authorPrentice, R.
dc.contributor.authorPresneau, N.
dc.contributor.authorPylkas, K.
dc.contributor.authorRack, B.
dc.contributor.authorRadice, P.
dc.contributor.authorRahman, N.
dc.contributor.authorRennert, G.
dc.contributor.authorRennert, H. S.
dc.contributor.authorRomero, A.
dc.contributor.authorRomm, J.
dc.contributor.authorSaloustros, E.
dc.contributor.authorSandler, D. P.
dc.contributor.authorSawyer, E. J.
dc.contributor.authorSchmutzler, R. K.
dc.contributor.authorSchneeweiss, A.
dc.contributor.authorScott, R. J.
dc.contributor.authorScott, C.
dc.contributor.authorSeal, S.
dc.contributor.authorSeynaeve, C.
dc.contributor.authorSmeets, A.
dc.contributor.authorSouthey, M. C.
dc.contributor.authorSpinelli, J. J.
dc.contributor.authorStone, J.
dc.contributor.authorSurowy, H.
dc.contributor.authorSwerdlow, A. J.
dc.contributor.authorTamimi, R.
dc.contributor.authorTapper, W.
dc.contributor.authorTaylor, J. A.
dc.contributor.authorTerry, M. B.
dc.contributor.authorTessier, D. C.
dc.contributor.authorThone, K.
dc.contributor.authorTollenaar, Raem
dc.contributor.authorTorres, D.
dc.contributor.authorTroester, M. A.
dc.contributor.authorTruong, T.
dc.contributor.authorUntch, M.
dc.contributor.authorVachon, C.
dc.contributor.authorVan Den Berg, D.
dc.contributor.authorvan den Ouweland, A. M. W.
dc.contributor.authorvan Veen, E. M.
dc.contributor.authorVincent, D.
dc.contributor.authorWaisfisz, Q.
dc.contributor.authorWeinberg, C. R.
dc.contributor.authorWendt, C.
dc.contributor.authorWhittemore, A. S.
dc.contributor.authorWildiers, H.
dc.contributor.authorWinqvist, R.
dc.contributor.authorWolk, A.
dc.contributor.authorXia, L.
dc.contributor.authorYang, X. H. R.
dc.contributor.authorZiogas, A.
dc.contributor.authorZiv, E.
dc.date.accessioned2021-11-29T09:29:06Z
dc.date.available2021-11-29T09:29:06Z
dc.date.issued2019
dc.identifier.issn0300-5771
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734940/pdf/dyy201.pdfes
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/30277539es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15751
dc.description.abstractBACKGROUND: In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. Findings from previous studies, however, have been inconsistent, and the nature of the associations is unclear. METHODS: We conducted Mendelian randomization analyses to evaluate the association of breast cancer risk, using genetic instruments, with fasting insulin, fasting glucose, 2-h glucose, body mass index (BMI) and BMI-adjusted waist-hip-ratio (WHRadj BMI). We first confirmed the association of these instruments with type 2 diabetes risk in a large diabetes genome-wide association study consortium. We then investigated their associations with breast cancer risk using individual-level data obtained from 98 842 cases and 83 464 controls of European descent in the Breast Cancer Association Consortium. RESULTS: All sets of instruments were associated with risk of type 2 diabetes. Associations with breast cancer risk were found for genetically predicted fasting insulin [odds ratio (OR) = 1.71 per standard deviation (SD) increase, 95% confidence interval (CI) = 1.26-2.31, p = 5.09 x 10-4], 2-h glucose (OR = 1.80 per SD increase, 95% CI = 1.3 0-2.49, p = 4.02 x 10-4), BMI (OR = 0.70 per 5-unit increase, 95% CI = 0.65-0.76, p = 5.05 x 10-19) and WHRadj BMI (OR = 0.85, 95% CI = 0.79-0.91, p = 9.22 x 10-6). Stratified analyses showed that genetically predicted fasting insulin was more closely related to risk of estrogen-receptor [ER]-positive cancer, whereas the associations with instruments of 2-h glucose, BMI and WHRadj BMI were consistent regardless of age, menopausal status, estrogen receptor status and family history of breast cancer. CONCLUSIONS: We confirmed the previously reported inverse association of genetically predicted BMI with breast cancer risk, and showed a positive association of genetically predicted fasting insulin and 2-h glucose and an inverse association of WHRadj BMI with breast cancer risk. Our study suggests that genetically determined obesity and glucose/insulin-related traits have an important role in the aetiology of breast cancer.es
dc.language.isoenges
dc.subject.meshAdult*
dc.subject.meshBreast Neoplasms*
dc.subject.meshMiddle Aged*
dc.subject.meshHumans*
dc.subject.meshBlood Glucose*
dc.subject.meshObesity*
dc.subject.meshWaist-Hip Ratio*
dc.subject.meshBody Mass Index*
dc.subject.meshMendelian Randomization Analysis*
dc.subject.meshDiabetes Mellitus*
dc.subject.meshInsulin*
dc.subject.meshAged*
dc.titleAssociations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysises
dc.typeArtigoes
dc.contributor.authorcorpBreast Cancer Association Consortium
dc.authorsophosShu, X.
dc.authorsophosWu, L.
dc.authorsophosKhankari, N. K.
dc.authorsophosShu, X. O.
dc.authorsophosWang, T. J.
dc.authorsophosMichailidou, K.
dc.authorsophosBolla, M. K.
dc.authorsophosWang, Q.
dc.authorsophosDennis, J.
dc.authorsophosMilne, R. L.
dc.authorsophosSchmidt, M. K.
dc.authorsophosPharoah, P. D. P.
dc.authorsophosAndrulis, I. L.
dc.authorsophosHunter, D. J.
dc.authorsophosSimard, J.
dc.authorsophosEaston, D. F.
dc.authorsophosZheng, W.
dc.authorsophosAlicia, B. F. J.
dc.authorsophosAnton-Culver, H.
dc.authorsophosAntonenkova, N. N.
dc.authorsophosArndt, V.
dc.authorsophosAronson, K. J.
dc.authorsophosAuer, P. L.
dc.authorsophosBarrdahl, M.
dc.authorsophosBaynes, C.
dc.authorsophosFreeman, L. E. B.
dc.authorsophosBeckmann, M. W.
dc.authorsophosBehrens, S.
dc.authorsophosBenitez, J.
dc.authorsophosBermisheva, M.
dc.authorsophosBlomqvist, C.
dc.authorsophosBogdanova, N. V.
dc.authorsophosBojesen, S. E.
dc.authorsophosBrauch, H.
dc.authorsophosBrenner, H.
dc.authorsophosBrinton, L.
dc.authorsophosBroberg, P.
dc.authorsophosBrucker, S. Y.
dc.authorsophosBruning, T.
dc.authorsophosBurwinkel, B.
dc.authorsophosCai, Q. Y.
dc.authorsophosCaldes, T.
dc.authorsophosCanzian, F.
dc.authorsophosCarter, B. D.
dc.authorsophosCastelao, J. E.
dc.authorsophosChang-Claude, J.
dc.authorsophosChenevix-Trench, G.
dc.authorsophosCheng, T. Y. D.
dc.authorsophosClarke, C. L.
dc.authorsophosConroy, D. M.
dc.authorsophosCouch, F. J.
dc.authorsophosCox, D. G.
dc.authorsophosCox, A.
dc.authorsophosCross, S. S.
dc.authorsophosCunningham, J. M.
dc.authorsophosCzene, K.
dc.authorsophosDaly, M. B.
dc.authorsophosDoheny, K. F.
dc.authorsophosDork, T.
dc.authorsophosdos-Santos-Silva, I.
dc.authorsophosDumont, M.
dc.authorsophosDunning, A. M.
dc.authorsophosDwek, M.
dc.authorsophosEarp, H. S.
dc.authorsophosEccles, D. M.
dc.authorsophosEliassen, A. H.
dc.authorsophosEngel, C.
dc.authorsophosEriksson, M.
dc.authorsophosEvans, D. G.
dc.authorsophosFachal, L.
dc.authorsophosFasching, P. A.
dc.authorsophosFigueroa, J.
dc.authorsophosFletcher, O.
dc.authorsophosFlyger, H.
dc.authorsophosFritschi, L.
dc.authorsophosGabrielson, M.
dc.authorsophosGago-Dominguez, M.
dc.authorsophosGapstur, S. M.
dc.authorsophosGarcia-Closas, M.
dc.authorsophosGaudet, M. M.
dc.authorsophosGhoussaini, M.
dc.authorsophosGiles, G. G.
dc.authorsophosGoldberg, M. S.
dc.authorsophosGoldgar, D. E.
dc.authorsophosGonzalez-Neira, A.
dc.authorsophosGuenel, P.
dc.authorsophosHahnen, E.
dc.authorsophosHaiman, C. A.
dc.authorsophosHakansson, N.
dc.authorsophosHall, P.
dc.authorsophosHallberg, E.
dc.authorsophosHamann, U.
dc.authorsophosHarrington, P.
dc.authorsophosHe, W.
dc.authorsophosHein, A.
dc.authorsophosHicks, B.
dc.authorsophosHillemanns, P.
dc.authorsophosHogervorst, F. B.
dc.authorsophosHollestelle, A.
dc.authorsophosHoover, R. N.
dc.authorsophosHopper, J. L.
dc.authorsophosHowell, A.
dc.authorsophosHuang, G.
dc.authorsophosJakubowska, A.
dc.authorsophosJanni, W.
dc.authorsophosJohn, E. M.
dc.authorsophosJohnson, N.
dc.authorsophosJones, K.
dc.authorsophosJung, A.
dc.authorsophosKaaks, R.
dc.authorsophosKabisch, M.
dc.authorsophosKerin, M. J.
dc.authorsophosKhusnutdinova, E.
dc.authorsophosKitahara, C. M.
dc.authorsophosKosma, V. M.
dc.authorsophosKoutros, S.
dc.authorsophosKraft, P.
dc.authorsophosKristensen, V. N.
dc.authorsophosLambrechts, D.
dc.authorsophosLe Marchand, L.
dc.authorsophosLindstrom, S.
dc.authorsophosLinet, M. S.
dc.authorsophosLissowska, J.
dc.authorsophosLoibl, S.
dc.authorsophosLubinski, J.
dc.authorsophosLuccarini, C.
dc.authorsophosLux, M. P.
dc.authorsophosMaishman, T.
dc.authorsophosKostovska, I. M.
dc.authorsophosMannermaa, A.
dc.authorsophosManoukian, S.
dc.authorsophosManson, J. E.
dc.authorsophosMargolin, S.
dc.authorsophosMavroudis, D.
dc.authorsophosMeijers-Heijboer, H.
dc.authorsophosMeindl, A.
dc.authorsophosMenon, U.
dc.authorsophosMeyer, J.
dc.authorsophosMulligan, A. M.
dc.authorsophosNeuhausen, S. L.
dc.authorsophosNevanlinna, H.
dc.authorsophosNeven, P.
dc.authorsophosNewman, W. T.
dc.authorsophosNielsen, S. F.
dc.authorsophosNordestgaard, B. G.
dc.authorsophosOlopade, O. I.
dc.authorsophosOlshan, A. F.
dc.authorsophosOlson, J. E.
dc.authorsophosOlsson, H.
dc.authorsophosOlswol, C.
dc.authorsophosOrr, N.
dc.authorsophosPerou, C. M.
dc.authorsophosPeto, J.
dc.authorsophosPlaseska-Karanfilska, D.
dc.authorsophosPrentice, R.
dc.authorsophosPresneau, N.
dc.authorsophosPylkas, K.
dc.authorsophosRack, B.
dc.authorsophosRadice, P.
dc.authorsophosRahman, N.
dc.authorsophosRennert, G.
dc.authorsophosRennert, H. S.
dc.authorsophosRomero, A.
dc.authorsophosRomm, J.
dc.authorsophosSaloustros, E.
dc.authorsophosSandler, D. P.
dc.authorsophosSawyer, E. J.
dc.authorsophosSchmutzler, R. K.
dc.authorsophosSchneeweiss, A.
dc.authorsophosScott, R. J.
dc.authorsophosScott, C.
dc.authorsophosSeal, S.
dc.authorsophosSeynaeve, C.
dc.authorsophosSmeets, A.
dc.authorsophosSouthey, M. C.
dc.authorsophosSpinelli, J. J.
dc.authorsophosStone, J.
dc.authorsophosSurowy, H.
dc.authorsophosSwerdlow, A. J.
dc.authorsophosTamimi, R.
dc.authorsophosTapper, W.
dc.authorsophosTaylor, J. A.
dc.authorsophosTerry, M. B.
dc.authorsophosTessier, D. C.
dc.authorsophosThone, K.
dc.authorsophosTollenaar, Raem
dc.authorsophosTorres, D.
dc.authorsophosTroester, M. A.
dc.authorsophosTruong, T.
dc.authorsophosUntch, M.
dc.authorsophosVachon, C.
dc.authorsophosVan Den Berg, D.
dc.authorsophosvan den Ouweland, A. M. W.
dc.authorsophosvan Veen, E. M.
dc.authorsophosVincent, D.
dc.authorsophosWaisfisz, Q.
dc.authorsophosWeinberg, C. R.
dc.authorsophosWendt, C.
dc.authorsophosWhittemore, A. S.
dc.authorsophosWildiers, H.
dc.authorsophosWinqvist, R.
dc.authorsophosWolk, A.
dc.authorsophosXia, L.
dc.authorsophosYang, X. H. R.
dc.authorsophosZiogas, A.
dc.authorsophosZiv, E.
dc.authorsophosBreast Canc Assoc, Consortium
dc.authorsophosCollaborators, Nbcs
dc.identifier.doi10.1093/ije/dyy201
dc.identifier.pmid30277539
dc.identifier.sophos31515
dc.issue.number3es
dc.journal.titleINTERNATIONAL JOURNAL OF EPIDEMIOLOGYes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.page.initial795es
dc.page.final806es
dc.rights.accessRightsembargoedAccesses
dc.subject.decsanálisis de la aleatorización mendeliana*
dc.subject.decsanciano*
dc.subject.decsinsulina*
dc.subject.decsneoplasias de la mama*
dc.subject.decsobesidad*
dc.subject.decsmediana edad*
dc.subject.decsglucosa sanguínea*
dc.subject.decshumanos*
dc.subject.decsadulto*
dc.subject.decsíndice de masa corporal*
dc.subject.decsdiabetes mellitus*
dc.subject.decsíndice cintura-cadera*
dc.subject.keywordIDISes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number48es


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