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dc.contributor.authorCalviño-Sampedro, C.
dc.contributor.authorGomez-Tourino, I.
dc.contributor.authorCordero, O. J.
dc.contributor.authorReche, P. A.
dc.contributor.authorGómez-Perosanz, M.
dc.contributor.authorSánchez-Trincado, J. L.
dc.contributor.authorRodríguez, M. Á
dc.contributor.authorMartís Sueiro, Aurelio Manuel
dc.contributor.authorViñuela Roldán, Juan 
dc.contributor.authorCalviño, R. V.
dc.date.accessioned2021-11-30T09:33:25Z
dc.date.available2021-11-30T09:33:25Z
dc.date.issued2019
dc.identifier.issn0892-6638
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/30817223es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15757
dc.description.abstractType 1 diabetes (T1D) results from the destruction of pancreatic beta-cells by the immune system, and CD8(+) T lymphocytes are critical actors in this autoimmune response. Pancreatic islets are surrounded by a mesh of nervous cells, the peri-insular Schwann cells, which are also targeted by autoreactive T lymphocytes and express specific antigens, such as the neurotrophic factor S100-beta. Previous work has shown increased proliferative responses to whole S100-beta in both human T1D patients and the nonobese diabetic (NOD) mouse model. We describe for the first time naturally processed and presented epitopes (NPPEs) presented by class I human leukocyte antigen-A*02:01 (A2.1) molecules derived from S100-beta. These NPPEs triggered IFN-gamma responses more frequently in both newly diagnosed and long-term T1D patients compared with healthy donors. Furthermore, the same NPPEs are recognized during the autoimmune response leading to diabetes in A2.1-transgenic NOD mice as early as 4 wk of age. Interestingly, when these NPPEs are used to prevent diabetes in this animal model, an acceleration of the disease is observed together with an exacerbation in insulitis and an increase in S100-beta-specific cytotoxicity in vaccinated animals. Whether these can be used in diabetes prevention needs to be carefully evaluated in animal models before use in future clinical assays.-Calvino-Sampedro, C., Gomez-Tourino, I., Cordero, O. J., Reche, P. A., Gomez-Perosanz, M., Sanchez-Trincado, J. L., Rodriguez, M. A., Sueiro, A. M., Vinuela, J. E., Calvino, R. V. Naturally presented HLA class I-restricted epitopes from the neurotrophic factor S100-beta are targets of the autoimmune response in type 1 diabetes.en
dc.language.isoenges
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshEpitopes*
dc.subject.meshHumans*
dc.subject.meshHLA-A2 Antigen*
dc.subject.meshMice*
dc.subject.meshInterferon-gamma*
dc.subject.meshDiabetes Mellitus*
dc.subject.meshAnimals*
dc.subject.meshK562 Cells*
dc.subject.meshS100 Calcium Binding Protein beta Subunit*
dc.titleNaturally presented HLA class I-restricted epitopes from the neurotrophic factor S100-β are targets of the autoimmune response in type 1 diabetesen
dc.typeArtigoes
dc.authorsophosCalviño-Sampedro, C.
dc.authorsophosGomez-Tourino, I.
dc.authorsophosCordero, O. J.
dc.authorsophosReche, P. A.
dc.authorsophosGómez-Perosanz, M.
dc.authorsophosSánchez-Trincado, J. L.
dc.authorsophosRodríguez, M. Á
dc.authorsophosSueiro, A. M.
dc.authorsophosViñuela, J. E.
dc.authorsophosCalviño, R. V.
dc.identifier.doi10.1096/fj.201802270R
dc.identifier.pmid30817223
dc.identifier.sophos31700
dc.issue.number5es
dc.journal.titleFASEB JOURNALes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Análise clínicoses
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Endocrinoloxíaes
dc.page.initial6390es
dc.page.final6401es
dc.relation.publisherversionhttps://faseb.onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.201802270R?download=truees
dc.rights.accessRightsopenAccesses
dc.subject.decsanimales*
dc.subject.decsantígeno HLA-A2*
dc.subject.decssubunidad beta de la proteína de unión al calcio S100*
dc.subject.decscélulas K562*
dc.subject.decshumanos*
dc.subject.decsepítopos*
dc.subject.decsdiabetes mellitus*
dc.subject.decsratones*
dc.subject.decsinterferón gamma*
dc.subject.keywordCHUSes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number33es


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