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dc.contributor.authorLeira, Y.
dc.contributor.authorIglesias Rey, Ramón
dc.contributor.authorGómez Lado, Noemí
dc.contributor.authorAguiar, P.
dc.contributor.authorSobrino Moreiras, Tomas 
dc.contributor.authorD’Aiuto, F.
dc.contributor.authorCastillo Sánchez, José 
dc.contributor.authorBlanco, J.
dc.contributor.authorCampos Pérez, Francisco 
dc.date.accessioned2021-11-30T11:11:33Z
dc.date.available2021-11-30T11:11:33Z
dc.date.issued2019
dc.identifier.issn1618-1247
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066291/pdf/10266_2019_Article_461.pdfes
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31583485es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15770
dc.description.abstractThe objective of this preclinical in vivo study was to determine changes in vascular inflammatory biomarkers in systemic circulation after injection of lipopolysaccharide (LPS) from Porphyromonas gingivalis (Pg) in rats. Experimental periodontitis was induced by injections of Pg-LPS. Gingival soft and hard tissues changes were analysed by means of magnetic resonance imaging and micro computed tomography. Serum levels of interleukin (IL)-6, IL-10, pentraxin (PTX) 3, and soluble fragment of tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) were determined at baseline and 24 h, 7, 14, and 21 days after periodontal induction. Significant periodontal inflammation and alveolar bone loss were evident at the end of periodontal induction. Experimental periodontitis posed an acute systemic inflammatory response with increased serum levels of IL-6 and PTX3 at 24 h post-induction, followed by a significant overexpression of sTWEAK at 7 days. This inflammatory state was maintained until the end of the experiment (21 days). As expected, IL-10 serum levels were significantly lower during the follow-up compared to baseline concentrations. In the present animal model, experimental periodontitis is associated with increased systemic inflammation. Further studies are needed to confirm whether PTX3 and sTWEAK could be useful biomarkers to investigate potential mechanisms underlying the relationship between periodontitis and atherosclerotic vascular diseases.en
dc.language.isoenges
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshRats*
dc.subject.meshX-Ray Microtomography*
dc.subject.meshPorphyromonas gingivalis*
dc.subject.meshAlveolar Bone Loss*
dc.subject.meshAnimals*
dc.subject.meshPeriodontitis*
dc.subject.meshInflammation*
dc.titlePeriodontitis and vascular inflammatory biomarkers: an experimental in vivo study in ratsen
dc.typeArtigoes
dc.authorsophosLeira, Y.
dc.authorsophosIglesias-Rey, R.
dc.authorsophosGómez-Lado, N.
dc.authorsophosAguiar, P.
dc.authorsophosSobrino, T.
dc.authorsophosD’Aiuto, F.
dc.authorsophosCastillo, J.
dc.authorsophosBlanco, J.
dc.authorsophosCampos, F.
dc.identifier.doi10.1007/s10266-019-00461-3
dc.identifier.pmid31583485
dc.identifier.sophos31766
dc.issue.number2es
dc.journal.titleOdontologyes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Neuroloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.page.initial202es
dc.page.final212es
dc.rights.accessRightsopenAccesses
dc.subject.decsperiodontitis*
dc.subject.decsanimales*
dc.subject.decsmicrotomografía de rayos X*
dc.subject.decspérdida de hueso alveolar*
dc.subject.decsPorphyromonas gingivalis*
dc.subject.decsinflamación*
dc.subject.decsratas*
dc.subject.keywordCHUSes
dc.subject.keywordIDISes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number108es


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