Expansion of different subpopulations of CD26 −/low T cells in allergic and non-allergic asthmatics
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Identificadores
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Fecha de publicación
2019Título de revista
Scientific Reports
Tipo de contenido
Artigo
DeCS
estudios de casos y controles | dipeptidil peptidasa-4 | mediana edad | linfocitos T | citometría de flujo | adulto | índice de gravedad de la enfermedad | células TH2 | anciano | células TH1 | adulto joven | humanos | asma | adolescenteMeSH
Adult | Middle Aged | Adolescent | T-Lymphocytes | Severity of Illness Index | Th2 Cells | Humans | Young Adult | Asthma | Dipeptidyl Peptidase 4 | Flow Cytometry | Case-Control Studies | Aged | Th1 CellsResumen
CD26 displays variable levels between effector (TH17 >> TH1 > TH2 > Treg) and naive/memory (memory > naive) CD4(+) T lymphocytes. Besides, IL-6/IL(-)6R is associated with TH17-differentiation and asthma severity. Allergic/atopic asthma (AA) is dominated by TH2 responses, while TH17 immunity might either modulate the TH2-dependent inflammation in AA or be an important mechanism boosting non-allergic asthma (NAA). Therefore, in this work we have compared the expression of CD26 and CD126 (IL-6Ralpha) in lymphocytes from different groups of donors: allergic (AA) and non-allergic (NAA) asthma, rhinitis, and healthy subjects. For this purpose, flow cytometry, haematological/biochemical, and in vitro proliferation assays were performed. Our results show a strong CD26-CD126 correlation and an over-representation of CD26(-) subsets with a highly-differentiated effector phenotype in AA (CD4(+)CD26(-/low) T cells) and NAA (CD4(-)CD26(-) gammadelta-T cells). In addition, we found that circulating levels of CD26 (sCD26) were reduced in both AA and NAA, while loss of CD126 expression on different leukocytes correlated with higher disease severity. Finally, selective inhibition of CD26-mRNA translation led to enhanced T cell proliferation in vitro. These findings support that CD26 down-modulation could play a role in facilitating the expansion of highly-differentiated effector T cell subsets in asthma.
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