Bendamustine as part of conditioning of autologous stem cell transplantation in patients with aggressive lymphoma: a phase 2 study from the GELTAMO group
Redondo, A. M.; Valcárcel, D.; González-Rodríguez, A. P.; Suárez-Lledó, M.; Bello López, José Luis; Canales, M.; Gayoso, J.; Colorado, M.; Jarque, I.; del Campo, R.; Arranz, R.; Terol, M. J.; Rifón, J. J.; Rodríguez, M. J.; Ramírez, M. J.; Castro, N.; Sánchez, A.; López-Jiménez, J.; Montes-Moreno, S.; Briones, J.; López, A.; Palomera, L.; López-Guillermo, A.; Caballero, D.; Martín, A.
![Thumbnail](/xmlui/themes/Mirage2//images/thumbnails/thumn_cientif.png)
Identificadores![](/xmlui/themes/Mirage2//images/despl_identif.png)
Identificadores
Visualización o descarga de ficheros![](/xmlui/themes/Mirage2//images/despl_contenidos.png)
Visualización o descarga de ficheros
Autor corporativo
Grupo Español de Linfomas y Trasplante Autologo de Medula OseaFecha de publicación
2019Título de revista
BRITISH JOURNAL OF HAEMATOLOGY
Tipo de contenido
Artigo
DeCS
linfoma | acondicionamiento para el trasplante | tasa de supervivencia | trasplante de células madre de sangre periférica | mediana edad | adulto | autoinjertos | protocolos de quimioterapia antineoplásica combinada | supervivencia sin enfermedad | anciano | melfalán | podofilotoxina | humanos | carmustina | citarabinaMeSH
Adult | Melphalan | Middle Aged | Podophyllotoxin | Autografts | Survival Rate | Antineoplastic Combined Chemotherapy Protocols | Cytarabine | Peripheral Blood Stem Cell Transplantation | Humans | Disease-Free Survival | Transplantation Conditioning | Lymphoma | Aged | CarmustineResumen
We conducted a phase 2 trial to evaluate the safety and efficacy of bendamustine instead of BCNU (carmustine) in the BEAM (BCNU, etoposide, cytarabine and melphalan) regimen (BendaEAM) as conditioning for autologous stem-cell transplantation (ASCT) in patients with aggressive lymphomas. The primary endpoint was 3-year progression-free survival (PFS). Sixty patients (median age 55 [28-71] years) were included. All patients (except one who died early) engrafted after a median of 11 (9-72) and 14 (4-53) days to achieve neutrophil and platelet counts of >0.5 x 10(9) /l and >20 x 10(9) /l, respectively. Non-relapse mortality at 100 days and 1 year were 3.3% and 6.7%, respectively. With a median follow-up of 67 (40-77) months, the estimated 3-year PFS and overall survival (OS) were 58% and 75%, respectively. Patients in partial response at study entry had significantly worse PFS and OS than patients who underwent ASCT in complete metabolic remission, and this was the only prognostic factor associated with both PFS (Relative risk [RR], 0.27 [95% confidence interval {CI} [0.12-0.56]) and OS (RR, 0.40 [95% CI 0.17-0.97]) in the multivariate analysis. BendaEAM conditioning is therefore a feasible and effective regimen in patients with aggressive lymphomas. However, patients not in complete metabolic remission at the time of transplant had poorer survival and so should be considered for alternative treatment strategies.
![](/xmlui/themes/Mirage2//images/final_lines.png)