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The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer
dc.contributor.author | Figlioli, G. | |
dc.contributor.author | Bogliolo, M. | |
dc.contributor.author | Catucci, I. | |
dc.contributor.author | Caleca, L. | |
dc.contributor.author | Lasheras, S. V. | |
dc.contributor.author | Pujol, R. | |
dc.contributor.author | Kiiski, J. I. | |
dc.contributor.author | Muranen, T. A. | |
dc.contributor.author | Barnes, D. R. | |
dc.contributor.author | Dennis, J. | |
dc.contributor.author | Michailidou, K. | |
dc.contributor.author | Bolla, M. K. | |
dc.contributor.author | Leslie, G. | |
dc.contributor.author | Aalfs, C. M. | |
dc.contributor.author | Balleine, R. | |
dc.contributor.author | Baxter, R. | |
dc.contributor.author | Braye, S. | |
dc.contributor.author | Carpenter, J. | |
dc.contributor.author | Dahlstrom, J. | |
dc.contributor.author | Forbes, J. | |
dc.contributor.author | Lee, C. S. | |
dc.contributor.author | Marsh, D. | |
dc.contributor.author | Morey, A. | |
dc.contributor.author | Pathmanathan, N. | |
dc.contributor.author | Scott, R. | |
dc.contributor.author | Simpson, P. | |
dc.contributor.author | Spigelman, A. | |
dc.contributor.author | Wilcken, N. | |
dc.contributor.author | Yip, D. | |
dc.contributor.author | Zeps, N. | |
dc.contributor.author | Adank, M. A. | |
dc.contributor.author | Adlard, J. | |
dc.contributor.author | Agata, S. | |
dc.contributor.author | Cadoo, K. | |
dc.contributor.author | Agnarsson, B. A. | |
dc.contributor.author | Ahearn, T. | |
dc.contributor.author | Aittomäki, K. | |
dc.contributor.author | Ambrosone, C. B. | |
dc.contributor.author | Andrews, L. | |
dc.contributor.author | Anton-Culver, H. | |
dc.contributor.author | Antonenkova, N. N. | |
dc.contributor.author | Arndt, V. | |
dc.contributor.author | Arnold, N. | |
dc.contributor.author | Aronson, K. J. | |
dc.contributor.author | Arun, B. K. | |
dc.contributor.author | Asseryanis, E. | |
dc.contributor.author | Auber, B. | |
dc.contributor.author | Auvinen, P. | |
dc.contributor.author | Azzollini, J. | |
dc.contributor.author | Balmaña, J. | |
dc.contributor.author | Barkardottir, R. B. | |
dc.contributor.author | Barrowdale, D. | |
dc.contributor.author | Barwell, J. | |
dc.contributor.author | Beane Freeman, L. E. | |
dc.contributor.author | Beauparlant, C. J. | |
dc.contributor.author | Beckmann, M. W. | |
dc.contributor.author | Behrens, S. | |
dc.contributor.author | Benitez, J. | |
dc.contributor.author | Berger, R. | |
dc.contributor.author | Bermisheva, M. | |
dc.contributor.author | Blanco, A. M. | |
dc.contributor.author | Blomqvist, C. | |
dc.contributor.author | Bogdanova, N. V. | |
dc.contributor.author | Bojesen, A. | |
dc.contributor.author | Bojesen, S. E. | |
dc.contributor.author | Bonanni, B. | |
dc.contributor.author | Borg, A. | |
dc.contributor.author | Brady, A. F. | |
dc.contributor.author | Brauch, H. | |
dc.contributor.author | Brenner, H. | |
dc.contributor.author | Brüning, T. | |
dc.contributor.author | Burwinkel, B. | |
dc.contributor.author | Buys, S. S. | |
dc.contributor.author | Caldés, T. | |
dc.contributor.author | Caliebe, A. | |
dc.contributor.author | Caligo, M. A. | |
dc.contributor.author | Campa, D. | |
dc.contributor.author | Campbell, I. G. | |
dc.contributor.author | Canzian, F. | |
dc.contributor.author | Castelao Fernández, José Esteban | |
dc.contributor.author | Chang-Claude, J. | |
dc.contributor.author | Chanock, S. J. | |
dc.contributor.author | Claes, K. B. M. | |
dc.contributor.author | Clarke, C. L. | |
dc.contributor.author | Collavoli, A. | |
dc.contributor.author | Conner, T. A. | |
dc.contributor.author | Cox, D. G. | |
dc.contributor.author | Cybulski, C. | |
dc.contributor.author | Czene, K. | |
dc.contributor.author | Daly, M. B. | |
dc.contributor.author | de la Hoya, M. | |
dc.contributor.author | Devilee, P. | |
dc.contributor.author | Diez, O. | |
dc.contributor.author | Ding, Y. C. | |
dc.contributor.author | Dite, G. S. | |
dc.contributor.author | Ditsch, N. | |
dc.contributor.author | Domchek, S. M. | |
dc.contributor.author | Dorfling, C. M. | |
dc.contributor.author | dos-Santos-Silva, I. | |
dc.contributor.author | Durda, K. | |
dc.contributor.author | Dwek, M. | |
dc.contributor.author | Eccles, D. M. | |
dc.contributor.author | Ekici, A. B. | |
dc.contributor.author | Eliassen, A. H. | |
dc.contributor.author | Ellberg, C. | |
dc.contributor.author | Eriksson, M. | |
dc.contributor.author | Evans, D. G. | |
dc.contributor.author | Fasching, P. A. | |
dc.contributor.author | Figueroa, J. | |
dc.contributor.author | Flyger, H. | |
dc.contributor.author | Foulkes, W. D. | |
dc.contributor.author | Friebel, T. M. | |
dc.contributor.author | Friedman, E. | |
dc.contributor.author | Gabrielson, M. | |
dc.contributor.author | Gaddam, P. | |
dc.contributor.author | Gago Dominguez, Manuela | |
dc.contributor.author | Gao, C. | |
dc.contributor.author | Gapstur, S. M. | |
dc.contributor.author | Garber, J. | |
dc.contributor.author | García-Closas, M. | |
dc.contributor.author | García-Sáenz, J. A. | |
dc.contributor.author | Gaudet, M. M. | |
dc.contributor.author | Gayther, S. A. | |
dc.contributor.author | Belotti, M. | |
dc.contributor.author | Bertrand, O. | |
dc.contributor.author | Birot, A. M. | |
dc.contributor.author | Buecher, B. | |
dc.contributor.author | Caputo, S. | |
dc.contributor.author | Dupré, A. | |
dc.contributor.author | Fourme, E. | |
dc.contributor.author | Gauthier-Villars, M. | |
dc.contributor.author | Golmard, L. | |
dc.contributor.author | Le Mentec, M. | |
dc.contributor.author | Moncoutier, V. | |
dc.contributor.author | de Pauw, A. | |
dc.contributor.author | Saule, C. | |
dc.contributor.author | Boutry-Kryza, N. | |
dc.contributor.author | Calender, A. | |
dc.contributor.author | Giraud, S. | |
dc.contributor.author | Léone, M. | |
dc.contributor.author | Bressac-de-Paillerets, B. | |
dc.contributor.author | Caron, O. | |
dc.contributor.author | Guillaud-Bataille, M. | |
dc.contributor.author | Bignon, Y. J. | |
dc.contributor.author | Uhrhammer, N. | |
dc.contributor.author | Bonadona, V. | |
dc.contributor.author | Lasset, C. | |
dc.contributor.author | Berthet, P. | |
dc.contributor.author | Castera, L. | |
dc.contributor.author | Vaur, D. | |
dc.contributor.author | Bourdon, V. | |
dc.contributor.author | Noguès, C. | |
dc.contributor.author | Noguchi, T. | |
dc.contributor.author | Popovici, C. | |
dc.contributor.author | Remenieras, A. | |
dc.contributor.author | Sobol, H. | |
dc.contributor.author | Coupier, I. | |
dc.contributor.author | Pujol, P. | |
dc.contributor.author | Adenis, C. | |
dc.contributor.author | Dumont, A. | |
dc.contributor.author | Révillion, F. | |
dc.contributor.author | Muller, D. | |
dc.contributor.author | Barouk-Simonet, E. | |
dc.contributor.author | Bonnet, F. | |
dc.contributor.author | Bubien, V. | |
dc.contributor.author | Longy, M. | |
dc.contributor.author | Sevenet, N. | |
dc.contributor.author | Gladieff, L. | |
dc.contributor.author | Guimbaud, R. | |
dc.contributor.author | Feillel, V. | |
dc.contributor.author | Toulas, C. | |
dc.contributor.author | Dreyfus, H. | |
dc.contributor.author | Leroux, C. D. | |
dc.contributor.author | Peysselon, M. | |
dc.contributor.author | Rebischung, C. | |
dc.contributor.author | Legrand, C. | |
dc.contributor.author | Baurand, A. | |
dc.contributor.author | Bertolone, G. | |
dc.contributor.author | Coron, F. | |
dc.contributor.author | Faivre, L. | |
dc.contributor.author | Jacquot, C. | |
dc.contributor.author | Lizard, S. | |
dc.contributor.author | Kientz, C. | |
dc.contributor.author | Lebrun, M. | |
dc.contributor.author | Prieur, F. | |
dc.contributor.author | Fert-Ferrer, S. | |
dc.contributor.author | Mari, V. | |
dc.contributor.author | Vénat-Bouvet, L. | |
dc.contributor.author | Bézieau, S. | |
dc.contributor.author | Delnatte, C. | |
dc.contributor.author | Mortemousque, I. | |
dc.contributor.author | Colas, C. | |
dc.contributor.author | Coulet, F. | |
dc.contributor.author | Soubrier, F. | |
dc.contributor.author | Warcoin, M. | |
dc.contributor.author | Bronner, M. | |
dc.contributor.author | Sokolowska, J. | |
dc.contributor.author | Collonge-Rame, M. A. | |
dc.contributor.author | Damette, A. | |
dc.contributor.author | Gesta, P. | |
dc.contributor.author | Lallaoui, H. | |
dc.contributor.author | Chiesa, J. | |
dc.contributor.author | Molina-Gomes, D. | |
dc.contributor.author | Ingster, O. | |
dc.contributor.author | Manouvrier-Hanu, S. | |
dc.contributor.author | Lejeune, S. | |
dc.contributor.author | Giles, G. G. | |
dc.contributor.author | Glendon, G. | |
dc.contributor.author | Godwin, A. K. | |
dc.contributor.author | Goldberg, M. S. | |
dc.contributor.author | Goldgar, D. E. | |
dc.contributor.author | Guénel, P. | |
dc.contributor.author | Gutierrez-Barrera, A. M. | |
dc.contributor.author | Haeberle, L. | |
dc.contributor.author | Haiman, C. A. | |
dc.contributor.author | Håkansson, N. | |
dc.contributor.author | Hall, P. | |
dc.contributor.author | Hamann, U. | |
dc.contributor.author | Harrington, P. A. | |
dc.contributor.author | Hein, A. | |
dc.contributor.author | Heyworth, J. | |
dc.contributor.author | Hillemanns, P. | |
dc.contributor.author | Hollestelle, A. | |
dc.contributor.author | Hopper, J. L. | |
dc.contributor.author | Hosgood, H. D., III | |
dc.contributor.author | Howell, A. | |
dc.contributor.author | Hu, C. | |
dc.contributor.author | Hulick, P. J. | |
dc.contributor.author | Hunter, D. J. | |
dc.contributor.author | Imyanitov, E. N. | |
dc.contributor.author | Aghmesheh, M. | |
dc.contributor.author | Greening, S. | |
dc.contributor.author | Amor, D. | |
dc.contributor.author | Gattas, M. | |
dc.contributor.author | Botes, L. | |
dc.contributor.author | Buckley, M. | |
dc.contributor.author | Friedlander, M. | |
dc.contributor.author | Koehler, J. | |
dc.contributor.author | Meiser, B. | |
dc.contributor.author | Saleh, M. | |
dc.contributor.author | Salisbury, E. | |
dc.contributor.author | Trainer, A. | |
dc.contributor.author | Tucker, K. | |
dc.contributor.author | Antill, Y. | |
dc.contributor.author | Dobrovic, A. | |
dc.contributor.author | Fellows, A. | |
dc.contributor.author | Fox, S. | |
dc.contributor.author | Harris, M. | |
dc.contributor.author | Nightingale, S. | |
dc.contributor.author | Phillips, K. | |
dc.contributor.author | Sambrook, J. | |
dc.contributor.author | Thorne, H. | |
dc.contributor.author | Armitage, S. | |
dc.contributor.author | Arnold, L. | |
dc.contributor.author | Kefford, R. | |
dc.contributor.author | Kirk, J. | |
dc.contributor.author | Rickard, E. | |
dc.contributor.author | Bastick, P. | |
dc.contributor.author | Beesley, J. | |
dc.contributor.author | Hayward, N. | |
dc.contributor.author | Spurdle, A. | |
dc.contributor.author | Walker, L. | |
dc.contributor.author | Beilby, J. | |
dc.contributor.author | Saunders, C. | |
dc.contributor.author | Bennett, I. | |
dc.contributor.author | Blackburn, A. | |
dc.contributor.author | Bogwitz, M. | |
dc.contributor.author | Gaff, C. | |
dc.contributor.author | Lindeman, G. | |
dc.contributor.author | Pachter, N. | |
dc.contributor.author | Scott, C. | |
dc.contributor.author | Sexton, A. | |
dc.contributor.author | Visvader, J. | |
dc.contributor.author | Taylor, J. | |
dc.contributor.author | Winship, I. | |
dc.contributor.author | Brennan, M. | |
dc.contributor.author | Brown, M. | |
dc.contributor.author | French, J. | |
dc.contributor.author | Edwards, S. | |
dc.contributor.author | Burgess, M. | |
dc.contributor.author | Burke, J. | |
dc.contributor.author | Patterson, B. | |
dc.contributor.author | Butow, P. | |
dc.contributor.author | Culling, B. | |
dc.contributor.author | Caldon, L. | |
dc.contributor.author | Callen, D. | |
dc.contributor.author | Chauhan, D. | |
dc.contributor.author | Eisenbruch, M. | |
dc.contributor.author | Heiniger, L. | |
dc.contributor.author | Chauhan, M. | |
dc.contributor.author | Christian, A. | |
dc.contributor.author | Dixon, J. | |
dc.contributor.author | Kidd, A. | |
dc.contributor.author | Cohen, P. | |
dc.contributor.author | Colley, A. | |
dc.contributor.author | Fenton, G. | |
dc.contributor.author | Crook, A. | |
dc.contributor.author | Dickson, R. | |
dc.contributor.author | Field, M. | |
dc.contributor.author | Cui, J. | |
dc.contributor.author | Cummings, M. | |
dc.contributor.author | Dawson, S. J. | |
dc.contributor.author | DeFazio, A. | |
dc.contributor.author | Delatycki, M. | |
dc.contributor.author | Dudding, T. | |
dc.contributor.author | Edkins, T. | |
dc.contributor.author | Farshid, G. | |
dc.contributor.author | Flanagan, J. | |
dc.contributor.author | Fong, P. | |
dc.contributor.author | Forrest, L. | |
dc.contributor.author | Gallego-Ortega, D. | |
dc.contributor.author | George, P. | |
dc.contributor.author | Gill, G. | |
dc.contributor.author | Kollias, J. | |
dc.contributor.author | Haan, E. | |
dc.contributor.author | Hart, S. | |
dc.contributor.author | Jenkins, M. | |
dc.contributor.author | Hunt, C. | |
dc.contributor.author | Lakhani, S. | |
dc.contributor.author | Lipton, L. | |
dc.contributor.author | Lobb, L. | |
dc.contributor.author | Mann, G. | |
dc.contributor.author | McLachlan, S. A. | |
dc.contributor.author | O’Connell, S. | |
dc.contributor.author | O’Sullivan, S. | |
dc.contributor.author | Pieper, E. | |
dc.contributor.author | Robinson, B. | |
dc.contributor.author | Saunus, J. | |
dc.contributor.author | Scott, E. | |
dc.contributor.author | Shelling, A. | |
dc.contributor.author | Williams, R. | |
dc.contributor.author | Young, M. A. | |
dc.contributor.author | Isaacs, C. | |
dc.contributor.author | Jakimovska, M. | |
dc.contributor.author | Jakubowska, A. | |
dc.contributor.author | James, P. | |
dc.contributor.author | Janavicius, R. | |
dc.contributor.author | Janni, W. | |
dc.contributor.author | John, E. M. | |
dc.contributor.author | Jones, M. E. | |
dc.contributor.author | Jung, A. | |
dc.contributor.author | Kaaks, R. | |
dc.contributor.author | Karlan, B. Y. | |
dc.contributor.author | Khusnutdinova, E. | |
dc.contributor.author | Kitahara, C. M. | |
dc.contributor.author | Konstantopoulou, I. | |
dc.contributor.author | Koutros, S. | |
dc.contributor.author | Kraft, P. | |
dc.contributor.author | Lambrechts, D. | |
dc.contributor.author | Lazaro, C. | |
dc.contributor.author | Le Marchand, L. | |
dc.contributor.author | Lester, J. | |
dc.contributor.author | Lesueur, F. | |
dc.contributor.author | Lilyquist, J. | |
dc.contributor.author | Loud, J. T. | |
dc.contributor.author | Lu, K. H. | |
dc.contributor.author | Luben, R. N. | |
dc.contributor.author | Lubinski, J. | |
dc.contributor.author | Mannermaa, A. | |
dc.contributor.author | Manoochehri, M. | |
dc.contributor.author | Manoukian, S. | |
dc.contributor.author | Margolin, S. | |
dc.contributor.author | Martens, J. W. M. | |
dc.contributor.author | Maurer, T. | |
dc.contributor.author | Mavroudis, D. | |
dc.contributor.author | Mebirouk, N. | |
dc.contributor.author | Meindl, A. | |
dc.contributor.author | Menon, U. | |
dc.contributor.author | Miller, A. | |
dc.contributor.author | Montagna, M. | |
dc.contributor.author | Nathanson, K. L. | |
dc.contributor.author | Neuhausen, S. L. | |
dc.contributor.author | Newman, W. G. | |
dc.contributor.author | Nguyen-Dumont, T. | |
dc.contributor.author | Nielsen, F. C. | |
dc.contributor.author | Nielsen, S. | |
dc.contributor.author | Nikitina-Zake, L. | |
dc.contributor.author | Offit, K. | |
dc.contributor.author | Olah, E. | |
dc.contributor.author | Olopade, O. I. | |
dc.contributor.author | Olshan, A. F. | |
dc.contributor.author | Olson, J. E. | |
dc.contributor.author | Olsson, H. | |
dc.contributor.author | Osorio, A. | |
dc.contributor.author | Ottini, L. | |
dc.contributor.author | Peissel, B. | |
dc.contributor.author | Peixoto, A. | |
dc.contributor.author | Peto, J. | |
dc.contributor.author | Plaseska-Karanfilska, D. | |
dc.contributor.author | Pocza, T. | |
dc.contributor.author | Presneau, N. | |
dc.contributor.author | Pujana, M. A. | |
dc.contributor.author | Punie, K. | |
dc.contributor.author | Rack, B. | |
dc.contributor.author | Rantala, J. | |
dc.contributor.author | Rashid, M. U. | |
dc.contributor.author | Rau-Murthy, R. | |
dc.contributor.author | Rennert, G. | |
dc.contributor.author | Lejbkowicz, F. | |
dc.contributor.author | Rhenius, V. | |
dc.contributor.author | Romero, A. | |
dc.contributor.author | Rookus, M. A. | |
dc.contributor.author | Ross, E. A. | |
dc.contributor.author | Rossing, M. | |
dc.contributor.author | Rudaitis, V. | |
dc.contributor.author | Ruebner, M. | |
dc.contributor.author | Saloustros, E. | |
dc.contributor.author | Sanden, K. | |
dc.contributor.author | Santamaría Cadavid, María | |
dc.contributor.author | Scheuner, M. T. | |
dc.contributor.author | Schmutzler, R. K. | |
dc.contributor.author | Schneider, M. | |
dc.contributor.author | Senter, L. | |
dc.contributor.author | Shah, M. | |
dc.contributor.author | Sharma, P. | |
dc.contributor.author | Shu, X. O. | |
dc.contributor.author | Simard, J. | |
dc.contributor.author | Singer, C. F. | |
dc.contributor.author | Sohn, C. | |
dc.contributor.author | Soucy, P. | |
dc.contributor.author | Southey, M. C. | |
dc.contributor.author | Spinelli, J. J. | |
dc.contributor.author | Steele, L. | |
dc.contributor.author | Stoppa-Lyonnet, D. | |
dc.contributor.author | Tapper, W. J. | |
dc.contributor.author | Teixeira, M. R. | |
dc.contributor.author | Terry, M. B. | |
dc.contributor.author | Thomassen, M. | |
dc.contributor.author | Thompson, J. | |
dc.contributor.author | Thull, D. L. | |
dc.contributor.author | Tischkowitz, M. | |
dc.contributor.author | Tollenaar, R. A. E. M. | |
dc.contributor.author | Torres, D. | |
dc.contributor.author | Troester, M. A. | |
dc.contributor.author | Truong, T. | |
dc.contributor.author | Tung, N. | |
dc.contributor.author | Untch, M. | |
dc.contributor.author | Vachon, C. M. | |
dc.contributor.author | van Rensburg, E. J. | |
dc.contributor.author | van Veen, E. M. | |
dc.contributor.author | Vega, A. | |
dc.contributor.author | Viel, A. | |
dc.contributor.author | Wappenschmidt, B. | |
dc.contributor.author | Weitzel, J. N. | |
dc.contributor.author | Wendt, C. | |
dc.contributor.author | Wieme, G. | |
dc.contributor.author | Wolk, A. | |
dc.contributor.author | Yang, X. R. | |
dc.contributor.author | Zheng, W. | |
dc.contributor.author | Ziogas, A. | |
dc.contributor.author | Zorn, K. K. | |
dc.contributor.author | Dunning, A. M. | |
dc.contributor.author | Lush, M. | |
dc.contributor.author | Wang, Q. | |
dc.contributor.author | McGuffog, L. | |
dc.contributor.author | Parsons, M. T. | |
dc.contributor.author | Pharoah, P. D. P. | |
dc.contributor.author | Fostira, F. | |
dc.contributor.author | Toland, A. E. | |
dc.contributor.author | Andrulis, I. L. | |
dc.contributor.author | Ramus, S. J. | |
dc.contributor.author | Swerdlow, A. J. | |
dc.contributor.author | Greene, M. H. | |
dc.contributor.author | Chung, W. K. | |
dc.contributor.author | Milne, R. L. | |
dc.contributor.author | Chenevix-Trench, G. | |
dc.contributor.author | Dörk, T. | |
dc.contributor.author | Schmidt, M. K. | |
dc.contributor.author | Easton, D. F. | |
dc.contributor.author | Radice, P. | |
dc.contributor.author | Hahnen, E. | |
dc.contributor.author | Antoniou, A. C. | |
dc.contributor.author | Couch, F. J. | |
dc.contributor.author | Nevanlinna, H. | |
dc.contributor.author | Surrallés, J. | |
dc.contributor.author | Peterlongo, P. | |
dc.date.accessioned | 2021-12-02T10:39:13Z | |
dc.date.available | 2021-12-02T10:39:13Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 2374-4677 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825205/pdf/41523_2019_Article_127.pdf | es |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/31700994 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/15789 | |
dc.description.abstract | Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM (-/-) patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors. | en |
dc.language.iso | eng | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer | en |
dc.type | Artigo | es |
dc.authorsophos | Figlioli, G. | |
dc.authorsophos | Bogliolo, M. | |
dc.authorsophos | Catucci, I. | |
dc.authorsophos | Caleca, L. | |
dc.authorsophos | Lasheras, S. V. | |
dc.authorsophos | Pujol, R. | |
dc.authorsophos | Kiiski, J. I. | |
dc.authorsophos | Muranen, T. A. | |
dc.authorsophos | Barnes, D. R. | |
dc.authorsophos | Dennis, J. | |
dc.authorsophos | Michailidou, K. | |
dc.authorsophos | Bolla, M. K. | |
dc.authorsophos | Leslie, G. | |
dc.authorsophos | Aalfs, C. M. | |
dc.authorsophos | Balleine, R. | |
dc.authorsophos | Baxter, R. | |
dc.authorsophos | Braye, S. | |
dc.authorsophos | Carpenter, J. | |
dc.authorsophos | Dahlstrom, J. | |
dc.authorsophos | Forbes, J. | |
dc.authorsophos | Lee, C. S. | |
dc.authorsophos | Marsh, D. | |
dc.authorsophos | Morey, A. | |
dc.authorsophos | Pathmanathan, N. | |
dc.authorsophos | Scott, R. | |
dc.authorsophos | Simpson, P. | |
dc.authorsophos | Spigelman, A. | |
dc.authorsophos | Wilcken, N. | |
dc.authorsophos | Yip, D. | |
dc.authorsophos | Zeps, N. | |
dc.authorsophos | Adank, M. A. | |
dc.authorsophos | Adlard, J. | |
dc.authorsophos | Agata, S. | |
dc.authorsophos | Cadoo, K. | |
dc.authorsophos | Agnarsson, B. A. | |
dc.authorsophos | Ahearn, T. | |
dc.authorsophos | Aittomäki, K. | |
dc.authorsophos | Ambrosone, C. B. | |
dc.authorsophos | Andrews, L. | |
dc.authorsophos | Anton-Culver, H. | |
dc.authorsophos | Antonenkova, N. N. | |
dc.authorsophos | Arndt, V. | |
dc.authorsophos | Arnold, N. | |
dc.authorsophos | Aronson, K. J. | |
dc.authorsophos | Arun, B. K. | |
dc.authorsophos | Asseryanis, E. | |
dc.authorsophos | Auber, B. | |
dc.authorsophos | Auvinen, P. | |
dc.authorsophos | Azzollini, J. | |
dc.authorsophos | Balmaña, J. | |
dc.authorsophos | Barkardottir, R. B. | |
dc.authorsophos | Barrowdale, D. | |
dc.authorsophos | Barwell, J. | |
dc.authorsophos | Beane Freeman, L. E. | |
dc.authorsophos | Beauparlant, C. J. | |
dc.authorsophos | Beckmann, M. W. | |
dc.authorsophos | Behrens, S. | |
dc.authorsophos | Benitez, J. | |
dc.authorsophos | Berger, R. | |
dc.authorsophos | Bermisheva, M. | |
dc.authorsophos | Blanco, A. M. | |
dc.authorsophos | Blomqvist, C. | |
dc.authorsophos | Bogdanova, N. V. | |
dc.authorsophos | Bojesen, A. | |
dc.authorsophos | Bojesen, S. E. | |
dc.authorsophos | Bonanni, B. | |
dc.authorsophos | Borg, A. | |
dc.authorsophos | Brady, A. F. | |
dc.authorsophos | Brauch, H. | |
dc.authorsophos | Brenner, H. | |
dc.authorsophos | Brüning, T. | |
dc.authorsophos | Burwinkel, B. | |
dc.authorsophos | Buys, S. S. | |
dc.authorsophos | Caldés, T. | |
dc.authorsophos | Caliebe, A. | |
dc.authorsophos | Caligo, M. A. | |
dc.authorsophos | Campa, D. | |
dc.authorsophos | Campbell, I. G. | |
dc.authorsophos | Canzian, F. | |
dc.authorsophos | Castelao, J. E. | |
dc.authorsophos | Chang-Claude, J. | |
dc.authorsophos | Chanock, S. J. | |
dc.authorsophos | Claes, K. B. M. | |
dc.authorsophos | Clarke, C. L. | |
dc.authorsophos | Collavoli, A. | |
dc.authorsophos | Conner, T. A. | |
dc.authorsophos | Cox, D. G. | |
dc.authorsophos | Cybulski, C. | |
dc.authorsophos | Czene, K. | |
dc.authorsophos | Daly, M. B. | |
dc.authorsophos | de la Hoya, M. | |
dc.authorsophos | Devilee, P. | |
dc.authorsophos | Diez, O. | |
dc.authorsophos | Ding, Y. C. | |
dc.authorsophos | Dite, G. S. | |
dc.authorsophos | Ditsch, N. | |
dc.authorsophos | Domchek, S. M. | |
dc.authorsophos | Dorfling, C. M. | |
dc.authorsophos | dos-Santos-Silva, I. | |
dc.authorsophos | Durda, K. | |
dc.authorsophos | Dwek, M. | |
dc.authorsophos | Eccles, D. M. | |
dc.authorsophos | Ekici, A. B. | |
dc.authorsophos | Eliassen, A. H. | |
dc.authorsophos | Ellberg, C. | |
dc.authorsophos | Eriksson, M. | |
dc.authorsophos | Evans, D. G. | |
dc.authorsophos | Fasching, P. A. | |
dc.authorsophos | Figueroa, J. | |
dc.authorsophos | Flyger, H. | |
dc.authorsophos | Foulkes, W. D. | |
dc.authorsophos | Friebel, T. M. | |
dc.authorsophos | Friedman, E. | |
dc.authorsophos | Gabrielson, M. | |
dc.authorsophos | Gaddam, P. | |
dc.authorsophos | Gago-Dominguez, M. | |
dc.authorsophos | Gao, C. | |
dc.authorsophos | Gapstur, S. M. | |
dc.authorsophos | Garber, J. | |
dc.authorsophos | García-Closas, M. | |
dc.authorsophos | García-Sáenz, J. A. | |
dc.authorsophos | Gaudet, M. M. | |
dc.authorsophos | Gayther, S. A. | |
dc.authorsophos | Belotti, M. | |
dc.authorsophos | Bertrand, O. | |
dc.authorsophos | Birot, A. M. | |
dc.authorsophos | Buecher, B. | |
dc.authorsophos | Caputo, S. | |
dc.authorsophos | Dupré, A. | |
dc.authorsophos | Fourme, E. | |
dc.authorsophos | Gauthier-Villars, M. | |
dc.authorsophos | Golmard, L. | |
dc.authorsophos | Le Mentec, M. | |
dc.authorsophos | Moncoutier, V. | |
dc.authorsophos | de Pauw, A. | |
dc.authorsophos | Saule, C. | |
dc.authorsophos | Boutry-Kryza, N. | |
dc.authorsophos | Calender, A. | |
dc.authorsophos | Giraud, S. | |
dc.authorsophos | Léone, M. | |
dc.authorsophos | Bressac-de-Paillerets, B. | |
dc.authorsophos | Caron, O. | |
dc.authorsophos | Guillaud-Bataille, M. | |
dc.authorsophos | Bignon, Y. J. | |
dc.authorsophos | Uhrhammer, N. | |
dc.authorsophos | Bonadona, V. | |
dc.authorsophos | Lasset, C. | |
dc.authorsophos | Berthet, P. | |
dc.authorsophos | Castera, L. | |
dc.authorsophos | Vaur, D. | |
dc.authorsophos | Bourdon, V. | |
dc.authorsophos | Noguès, C. | |
dc.authorsophos | Noguchi, T. | |
dc.authorsophos | Popovici, C. | |
dc.authorsophos | Remenieras, A. | |
dc.authorsophos | Sobol, H. | |
dc.authorsophos | Coupier, I. | |
dc.authorsophos | Pujol, P. | |
dc.authorsophos | Adenis, C. | |
dc.authorsophos | Dumont, A. | |
dc.authorsophos | Révillion, F. | |
dc.authorsophos | Muller, D. | |
dc.authorsophos | Barouk-Simonet, E. | |
dc.authorsophos | Bonnet, F. | |
dc.authorsophos | Bubien, V. | |
dc.authorsophos | Longy, M. | |
dc.authorsophos | Sevenet, N. | |
dc.authorsophos | Gladieff, L. | |
dc.authorsophos | Guimbaud, R. | |
dc.authorsophos | Feillel, V. | |
dc.authorsophos | Toulas, C. | |
dc.authorsophos | Dreyfus, H. | |
dc.authorsophos | Leroux, C. D. | |
dc.authorsophos | Peysselon, M. | |
dc.authorsophos | Rebischung, C. | |
dc.authorsophos | Legrand, C. | |
dc.authorsophos | Baurand, A. | |
dc.authorsophos | Bertolone, G. | |
dc.authorsophos | Coron, F. | |
dc.authorsophos | Faivre, L. | |
dc.authorsophos | Jacquot, C. | |
dc.authorsophos | Lizard, S. | |
dc.authorsophos | Kientz, C. | |
dc.authorsophos | Lebrun, M. | |
dc.authorsophos | Prieur, F. | |
dc.authorsophos | Fert-Ferrer, S. | |
dc.authorsophos | Mari, V. | |
dc.authorsophos | Vénat-Bouvet, L. | |
dc.authorsophos | Bézieau, S. | |
dc.authorsophos | Delnatte, C. | |
dc.authorsophos | Mortemousque, I. | |
dc.authorsophos | Colas, C. | |
dc.authorsophos | Coulet, F. | |
dc.authorsophos | Soubrier, F. | |
dc.authorsophos | Warcoin, M. | |
dc.authorsophos | Bronner, M. | |
dc.authorsophos | Sokolowska, J. | |
dc.authorsophos | Collonge-Rame, M. A. | |
dc.authorsophos | Damette, A. | |
dc.authorsophos | Gesta, P. | |
dc.authorsophos | Lallaoui, H. | |
dc.authorsophos | Chiesa, J. | |
dc.authorsophos | Molina-Gomes, D. | |
dc.authorsophos | Ingster, O. | |
dc.authorsophos | Manouvrier-Hanu, S. | |
dc.authorsophos | Lejeune, S. | |
dc.authorsophos | Giles, G. G. | |
dc.authorsophos | Glendon, G. | |
dc.authorsophos | Godwin, A. K. | |
dc.authorsophos | Goldberg, M. S. | |
dc.authorsophos | Goldgar, D. E. | |
dc.authorsophos | Guénel, P. | |
dc.authorsophos | Gutierrez-Barrera, A. M. | |
dc.authorsophos | Haeberle, L. | |
dc.authorsophos | Haiman, C. A. | |
dc.authorsophos | Håkansson, N. | |
dc.authorsophos | Hall, P. | |
dc.authorsophos | Hamann, U. | |
dc.authorsophos | Harrington, P. A. | |
dc.authorsophos | Hein, A. | |
dc.authorsophos | Heyworth, J. | |
dc.authorsophos | Hillemanns, P. | |
dc.authorsophos | Hollestelle, A. | |
dc.authorsophos | Hopper, J. L. | |
dc.authorsophos | Hosgood, H. D., III | |
dc.authorsophos | Howell, A. | |
dc.authorsophos | Hu, C. | |
dc.authorsophos | Hulick, P. J. | |
dc.authorsophos | Hunter, D. J. | |
dc.authorsophos | Imyanitov, E. N. | |
dc.authorsophos | Aghmesheh, M. | |
dc.authorsophos | Greening, S. | |
dc.authorsophos | Amor, D. | |
dc.authorsophos | Gattas, M. | |
dc.authorsophos | Botes, L. | |
dc.authorsophos | Buckley, M. | |
dc.authorsophos | Friedlander, M. | |
dc.authorsophos | Koehler, J. | |
dc.authorsophos | Meiser, B. | |
dc.authorsophos | Saleh, M. | |
dc.authorsophos | Salisbury, E. | |
dc.authorsophos | Trainer, A. | |
dc.authorsophos | Tucker, K. | |
dc.authorsophos | Antill, Y. | |
dc.authorsophos | Dobrovic, A. | |
dc.authorsophos | Fellows, A. | |
dc.authorsophos | Fox, S. | |
dc.authorsophos | Harris, M. | |
dc.authorsophos | Nightingale, S. | |
dc.authorsophos | Phillips, K. | |
dc.authorsophos | Sambrook, J. | |
dc.authorsophos | Thorne, H. | |
dc.authorsophos | Armitage, S. | |
dc.authorsophos | Arnold, L. | |
dc.authorsophos | Kefford, R. | |
dc.authorsophos | Kirk, J. | |
dc.authorsophos | Rickard, E. | |
dc.authorsophos | Bastick, P. | |
dc.authorsophos | Beesley, J. | |
dc.authorsophos | Hayward, N. | |
dc.authorsophos | Spurdle, A. | |
dc.authorsophos | Walker, L. | |
dc.authorsophos | Beilby, J. | |
dc.authorsophos | Saunders, C. | |
dc.authorsophos | Bennett, I. | |
dc.authorsophos | Blackburn, A. | |
dc.authorsophos | Bogwitz, M. | |
dc.authorsophos | Gaff, C. | |
dc.authorsophos | Lindeman, G. | |
dc.authorsophos | Pachter, N. | |
dc.authorsophos | Scott, C. | |
dc.authorsophos | Sexton, A. | |
dc.authorsophos | Visvader, J. | |
dc.authorsophos | Taylor, J. | |
dc.authorsophos | Winship, I. | |
dc.authorsophos | Brennan, M. | |
dc.authorsophos | Brown, M. | |
dc.authorsophos | French, J. | |
dc.authorsophos | Edwards, S. | |
dc.authorsophos | Burgess, M. | |
dc.authorsophos | Burke, J. | |
dc.authorsophos | Patterson, B. | |
dc.authorsophos | Butow, P. | |
dc.authorsophos | Culling, B. | |
dc.authorsophos | Caldon, L. | |
dc.authorsophos | Callen, D. | |
dc.authorsophos | Chauhan, D. | |
dc.authorsophos | Eisenbruch, M. | |
dc.authorsophos | Heiniger, L. | |
dc.authorsophos | Chauhan, M. | |
dc.authorsophos | Christian, A. | |
dc.authorsophos | Dixon, J. | |
dc.authorsophos | Kidd, A. | |
dc.authorsophos | Cohen, P. | |
dc.authorsophos | Colley, A. | |
dc.authorsophos | Fenton, G. | |
dc.authorsophos | Crook, A. | |
dc.authorsophos | Dickson, R. | |
dc.authorsophos | Field, M. | |
dc.authorsophos | Cui, J. | |
dc.authorsophos | Cummings, M. | |
dc.authorsophos | Dawson, S. J. | |
dc.authorsophos | DeFazio, A. | |
dc.authorsophos | Delatycki, M. | |
dc.authorsophos | Dudding, T. | |
dc.authorsophos | Edkins, T. | |
dc.authorsophos | Farshid, G. | |
dc.authorsophos | Flanagan, J. | |
dc.authorsophos | Fong, P. | |
dc.authorsophos | Forrest, L. | |
dc.authorsophos | Gallego-Ortega, D. | |
dc.authorsophos | George, P. | |
dc.authorsophos | Gill, G. | |
dc.authorsophos | Kollias, J. | |
dc.authorsophos | Haan, E. | |
dc.authorsophos | Hart, S. | |
dc.authorsophos | Jenkins, M. | |
dc.authorsophos | Hunt, C. | |
dc.authorsophos | Lakhani, S. | |
dc.authorsophos | Lipton, L. | |
dc.authorsophos | Lobb, L. | |
dc.authorsophos | Mann, G. | |
dc.authorsophos | McLachlan, S. A. | |
dc.authorsophos | O’Connell, S. | |
dc.authorsophos | O’Sullivan, S. | |
dc.authorsophos | Pieper, E. | |
dc.authorsophos | Robinson, B. | |
dc.authorsophos | Saunus, J. | |
dc.authorsophos | Scott, E. | |
dc.authorsophos | Shelling, A. | |
dc.authorsophos | Williams, R. | |
dc.authorsophos | Young, M. A. | |
dc.authorsophos | Isaacs, C. | |
dc.authorsophos | Jakimovska, M. | |
dc.authorsophos | Jakubowska, A. | |
dc.authorsophos | James, P. | |
dc.authorsophos | Janavicius, R. | |
dc.authorsophos | Janni, W. | |
dc.authorsophos | John, E. M. | |
dc.authorsophos | Jones, M. E. | |
dc.authorsophos | Jung, A. | |
dc.authorsophos | Kaaks, R. | |
dc.authorsophos | Karlan, B. Y. | |
dc.authorsophos | Khusnutdinova, E. | |
dc.authorsophos | Kitahara, C. M. | |
dc.authorsophos | Konstantopoulou, I. | |
dc.authorsophos | Koutros, S. | |
dc.authorsophos | Kraft, P. | |
dc.authorsophos | Lambrechts, D. | |
dc.authorsophos | Lazaro, C. | |
dc.authorsophos | Le Marchand, L. | |
dc.authorsophos | Lester, J. | |
dc.authorsophos | Lesueur, F. | |
dc.authorsophos | Lilyquist, J. | |
dc.authorsophos | Loud, J. T. | |
dc.authorsophos | Lu, K. H. | |
dc.authorsophos | Luben, R. N. | |
dc.authorsophos | Lubinski, J. | |
dc.authorsophos | Mannermaa, A. | |
dc.authorsophos | Manoochehri, M. | |
dc.authorsophos | Manoukian, S. | |
dc.authorsophos | Margolin, S. | |
dc.authorsophos | Martens, J. W. M. | |
dc.authorsophos | Maurer, T. | |
dc.authorsophos | Mavroudis, D. | |
dc.authorsophos | Mebirouk, N. | |
dc.authorsophos | Meindl, A. | |
dc.authorsophos | Menon, U. | |
dc.authorsophos | Miller, A. | |
dc.authorsophos | Montagna, M. | |
dc.authorsophos | Nathanson, K. L. | |
dc.authorsophos | Neuhausen, S. L. | |
dc.authorsophos | Newman, W. G. | |
dc.authorsophos | Nguyen-Dumont, T. | |
dc.authorsophos | Nielsen, F. C. | |
dc.authorsophos | Nielsen, S. | |
dc.authorsophos | Nikitina-Zake, L. | |
dc.authorsophos | Offit, K. | |
dc.authorsophos | Olah, E. | |
dc.authorsophos | Olopade, O. I. | |
dc.authorsophos | Olshan, A. F. | |
dc.authorsophos | Olson, J. E. | |
dc.authorsophos | Olsson, H. | |
dc.authorsophos | Osorio, A. | |
dc.authorsophos | Ottini, L. | |
dc.authorsophos | Peissel, B. | |
dc.authorsophos | Peixoto, A. | |
dc.authorsophos | Peto, J. | |
dc.authorsophos | Plaseska-Karanfilska, D. | |
dc.authorsophos | Pocza, T. | |
dc.authorsophos | Presneau, N. | |
dc.authorsophos | Pujana, M. A. | |
dc.authorsophos | Punie, K. | |
dc.authorsophos | Rack, B. | |
dc.authorsophos | Rantala, J. | |
dc.authorsophos | Rashid, M. U. | |
dc.authorsophos | Rau-Murthy, R. | |
dc.authorsophos | Rennert, G. | |
dc.authorsophos | Lejbkowicz, F. | |
dc.authorsophos | Rhenius, V. | |
dc.authorsophos | Romero, A. | |
dc.authorsophos | Rookus, M. A. | |
dc.authorsophos | Ross, E. A. | |
dc.authorsophos | Rossing, M. | |
dc.authorsophos | Rudaitis, V. | |
dc.authorsophos | Ruebner, M. | |
dc.authorsophos | Saloustros, E. | |
dc.authorsophos | Sanden, K. | |
dc.authorsophos | Santamariña, M. | |
dc.authorsophos | Scheuner, M. T. | |
dc.authorsophos | Schmutzler, R. K. | |
dc.authorsophos | Schneider, M. | |
dc.authorsophos | Senter, L. | |
dc.authorsophos | Shah, M. | |
dc.authorsophos | Sharma, P. | |
dc.authorsophos | Shu, X. O. | |
dc.authorsophos | Simard, J. | |
dc.authorsophos | Singer, C. F. | |
dc.authorsophos | Sohn, C. | |
dc.authorsophos | Soucy, P. | |
dc.authorsophos | Southey, M. C. | |
dc.authorsophos | Spinelli, J. J. | |
dc.authorsophos | Steele, L. | |
dc.authorsophos | Stoppa-Lyonnet, D. | |
dc.authorsophos | Tapper, W. J. | |
dc.authorsophos | Teixeira, M. R. | |
dc.authorsophos | Terry, M. B. | |
dc.authorsophos | Thomassen, M. | |
dc.authorsophos | Thompson, J. | |
dc.authorsophos | Thull, D. L. | |
dc.authorsophos | Tischkowitz, M. | |
dc.authorsophos | Tollenaar, R. A. E. M. | |
dc.authorsophos | Torres, D. | |
dc.authorsophos | Troester, M. A. | |
dc.authorsophos | Truong, T. | |
dc.authorsophos | Tung, N. | |
dc.authorsophos | Untch, M. | |
dc.authorsophos | Vachon, C. M. | |
dc.authorsophos | van Rensburg, E. J. | |
dc.authorsophos | van Veen, E. M. | |
dc.authorsophos | Vega, A. | |
dc.authorsophos | Viel, A. | |
dc.authorsophos | Wappenschmidt, B. | |
dc.authorsophos | Weitzel, J. N. | |
dc.authorsophos | Wendt, C. | |
dc.authorsophos | Wieme, G. | |
dc.authorsophos | Wolk, A. | |
dc.authorsophos | Yang, X. R. | |
dc.authorsophos | Zheng, W. | |
dc.authorsophos | Ziogas, A. | |
dc.authorsophos | Zorn, K. K. | |
dc.authorsophos | Dunning, A. M. | |
dc.authorsophos | Lush, M. | |
dc.authorsophos | Wang, Q. | |
dc.authorsophos | McGuffog, L. | |
dc.authorsophos | Parsons, M. T. | |
dc.authorsophos | Pharoah, P. D. P. | |
dc.authorsophos | Fostira, F. | |
dc.authorsophos | Toland, A. E. | |
dc.authorsophos | Andrulis, I. L. | |
dc.authorsophos | Ramus, S. J. | |
dc.authorsophos | Swerdlow, A. J. | |
dc.authorsophos | Greene, M. H. | |
dc.authorsophos | Chung, W. K. | |
dc.authorsophos | Milne, R. L. | |
dc.authorsophos | Chenevix-Trench, G. | |
dc.authorsophos | Dörk, T. | |
dc.authorsophos | Schmidt, M. K. | |
dc.authorsophos | Easton, D. F. | |
dc.authorsophos | Radice, P. | |
dc.authorsophos | Hahnen, E. | |
dc.authorsophos | Antoniou, A. C. | |
dc.authorsophos | Couch, F. J. | |
dc.authorsophos | Nevanlinna, H. | |
dc.authorsophos | Surrallés, J. | |
dc.authorsophos | Peterlongo, P. | |
dc.authorsophos | Investigators, Abctb | |
dc.authorsophos | Collaborators, Gemo Study | |
dc.authorsophos | KconFab | |
dc.identifier.doi | 10.1038/s41523-019-0127-5 | |
dc.identifier.pmid | 31700994 | |
dc.identifier.sophos | 31738 | |
dc.issue.number | 1 | es |
dc.journal.title | NPJ BREAST CANCER | es |
dc.organization | Servizo Galego de Saúde::Dirección Xeral de Asistencia Sanitaria::Fundación Pública Galega de Medicina Xenómica | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica Ourense-Pontevedra-Vigo (IBI) | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) | es |
dc.rights.accessRights | openAccess | es |
dc.subject.keyword | FPGMX | es |
dc.subject.keyword | IISGS | es |
dc.subject.keyword | IDIS | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 5 | es |