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Association analyses identify 31 new risk loci for colorectal cancer susceptibility

dc.contributor.authorLaw, P. J.
dc.contributor.authorTimofeeva, M.
dc.contributor.authorFernández Rozadilla, Ceres
dc.contributor.authorBroderick, P.
dc.contributor.authorStudd, J.
dc.contributor.authorFernandez-Tajes, J.
dc.contributor.authorFarrington, S.
dc.contributor.authorSvinti, V.
dc.contributor.authorPalles, C.
dc.contributor.authorOrlando, G.
dc.contributor.authorSud, A.
dc.contributor.authorHolroyd, A.
dc.contributor.authorPenegar, S.
dc.contributor.authorTheodoratou, E.
dc.contributor.authorVaughan-Shaw, P.
dc.contributor.authorCampbell, H.
dc.contributor.authorZgaga, L.
dc.contributor.authorHayward, C.
dc.contributor.authorCampbell, A.
dc.contributor.authorHarris, S.
dc.contributor.authorDeary, I. J.
dc.contributor.authorStarr, J.
dc.contributor.authorGatcombe, L.
dc.contributor.authorPinna, M.
dc.contributor.authorBriggs, S.
dc.contributor.authorMartin, L.
dc.contributor.authorJaeger, E.
dc.contributor.authorSharma-Oates, A.
dc.contributor.authorEast, J.
dc.contributor.authorLeedham, S.
dc.contributor.authorArnold, R.
dc.contributor.authorJohnstone, E.
dc.contributor.authorWang, H.
dc.contributor.authorKerr, D.
dc.contributor.authorKerr, R.
dc.contributor.authorMaughan, T.
dc.contributor.authorKaplan, R.
dc.contributor.authorAl-Tassan, N.
dc.contributor.authorPalin, K.
dc.contributor.authorHänninen, U. A.
dc.contributor.authorCajuso, T.
dc.contributor.authorTanskanen, T.
dc.contributor.authorKondelin, J.
dc.contributor.authorKaasinen, E.
dc.contributor.authorSarin, A. P.
dc.contributor.authorEriksson, J. G.
dc.contributor.authorRissanen, H.
dc.contributor.authorKnekt, P.
dc.contributor.authorPukkala, E.
dc.contributor.authorJousilahti, P.
dc.contributor.authorSalomaa, V.
dc.contributor.authorRipatti, S.
dc.contributor.authorPalotie, A.
dc.contributor.authorRenkonen-Sinisalo, L.
dc.contributor.authorLepistö, A.
dc.contributor.authorBöhm, J.
dc.contributor.authorMecklin, J. P.
dc.contributor.authorBuchanan, D. D.
dc.contributor.authorWin, A. K.
dc.contributor.authorHopper, J.
dc.contributor.authorJenkins, M. E.
dc.contributor.authorLindor, N. M.
dc.contributor.authorNewcomb, P. A.
dc.contributor.authorGallinger, S.
dc.contributor.authorDuggan, D.
dc.contributor.authorCasey, G.
dc.contributor.authorHoffmann, P.
dc.contributor.authorNöthen, M. M.
dc.contributor.authorJöckel, K. H.
dc.contributor.authorEaston, D. F.
dc.contributor.authorPharoah, P. D. P.
dc.contributor.authorPeto, J.
dc.contributor.authorCanzian, F.
dc.contributor.authorSwerdlow, A.
dc.contributor.authorEeles, R. A.
dc.contributor.authorKote-Jarai, Z.
dc.contributor.authorMuir, K.
dc.contributor.authorPashayan, N.
dc.contributor.authorHenderson, B. E.
dc.contributor.authorHaiman, C. A.
dc.contributor.authorSchumacher, F. R.
dc.contributor.authorAl Olama, A. A.
dc.contributor.authorBenlloch, S.
dc.contributor.authorBerndt, S. I.
dc.contributor.authorConti, D. V.
dc.contributor.authorWiklund, F.
dc.contributor.authorChanock, S.
dc.contributor.authorGapstur, S.
dc.contributor.authorStevens, V. L.
dc.contributor.authorTangen, C. M.
dc.contributor.authorBatra, J.
dc.contributor.authorClements, J.
dc.contributor.authorGronberg, H.
dc.contributor.authorSchleutker, J.
dc.contributor.authorAlbanes, D.
dc.contributor.authorWolk, A.
dc.contributor.authorWest, C.
dc.contributor.authorMucci, L.
dc.contributor.authorCancel-Tassin, G.
dc.contributor.authorKoutros, S.
dc.contributor.authorSorensen, K. D.
dc.contributor.authorGrindedal, E. M.
dc.contributor.authorNeal, D. E.
dc.contributor.authorHamdy, F. C.
dc.contributor.authorDonovan, J. L.
dc.contributor.authorTravis, R. C.
dc.contributor.authorHamilton, R. J.
dc.contributor.authorIngles, S. A.
dc.contributor.authorRosenstein, B. S.
dc.contributor.authorLu, Y. J.
dc.contributor.authorGiles, G. G.
dc.contributor.authorKibel, A. S.
dc.contributor.authorVega Gliemmo, Ana
dc.contributor.authorKogevinas, M.
dc.contributor.authorPenney, K. L.
dc.contributor.authorPark, J. Y.
dc.contributor.authorStanford, J. L.
dc.contributor.authorCybulski, C.
dc.contributor.authorNordestgaard, B. G.
dc.contributor.authorMaier, C.
dc.contributor.authorKim, J.
dc.contributor.authorJohn, E. M.
dc.contributor.authorTeixeira, M. R.
dc.contributor.authorNeuhausen, S. L.
dc.contributor.authorDe Ruyck, K.
dc.contributor.authorRazack, A.
dc.contributor.authorNewcomb, L. F.
dc.contributor.authorGamulin, M.
dc.contributor.authorKaneva, R.
dc.contributor.authorUsmani, N.
dc.contributor.authorClaessens, F.
dc.contributor.authorTownsend, P. A.
dc.contributor.authorGago-Dominguez, M.
dc.contributor.authorRoobol, M. J.
dc.contributor.authorMenegaux, F.
dc.contributor.authorKhaw, K. T.
dc.contributor.authorCannon-Albright, L.
dc.contributor.authorPandha, H.
dc.contributor.authorThibodeau, S. N.
dc.contributor.authorHarkin, A.
dc.contributor.authorAllan, K.
dc.contributor.authorMcQueen, J.
dc.contributor.authorPaul, J.
dc.contributor.authorIveson, T.
dc.contributor.authorSaunders, M.
dc.contributor.authorButterbach, K.
dc.contributor.authorChang-Claude, J.
dc.contributor.authorHoffmeister, M.
dc.contributor.authorBrenner, H.
dc.contributor.authorKirac, I.
dc.contributor.authorMatošević, P.
dc.contributor.authorHofer, P.
dc.contributor.authorBrezina, S.
dc.contributor.authorGsur, A.
dc.contributor.authorCheadle, J. P.
dc.contributor.authorAaltonen, L. A.
dc.contributor.authorTomlinson, I.
dc.contributor.authorHoulston, R. S.
dc.contributor.authorDunlop, M. G.
dc.date.accessioned2021-12-02T12:43:26Z
dc.date.available2021-12-02T12:43:26Z
dc.date.issued2019
dc.identifier.issn2041-1723
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517433/pdf/41467_2019_Article_9775.pdfes
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31089142es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15791
dc.description.abstractColorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.en
dc.language.isoenges
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshRisk Factors*
dc.subject.meshEuropean Continental Ancestry Group*
dc.subject.meshGenetic Loci*
dc.subject.meshMiddle Aged*
dc.subject.meshInheritance Patterns*
dc.subject.meshHumans*
dc.subject.meshGenome-Wide Association Study*
dc.subject.meshCase-Control Studies*
dc.subject.meshGenetic Predisposition to Disease*
dc.subject.meshColorectal Neoplasms*
dc.subject.meshAsian Continental Ancestry Group*
dc.titleAssociation analyses identify 31 new risk loci for colorectal cancer susceptibilityen
dc.typeArtigoes
dc.contributor.authorcorpPractical consortium
dc.authorsophosLaw, P. J.
dc.authorsophosTimofeeva, M.
dc.authorsophosFernandez-Rozadilla, C.
dc.authorsophosBroderick, P.
dc.authorsophosStudd, J.
dc.authorsophosFernandez-Tajes, J.
dc.authorsophosFarrington, S.
dc.authorsophosSvinti, V.
dc.authorsophosPalles, C.
dc.authorsophosOrlando, G.
dc.authorsophosSud, A.
dc.authorsophosHolroyd, A.
dc.authorsophosPenegar, S.
dc.authorsophosTheodoratou, E.
dc.authorsophosVaughan-Shaw, P.
dc.authorsophosCampbell, H.
dc.authorsophosZgaga, L.
dc.authorsophosHayward, C.
dc.authorsophosCampbell, A.
dc.authorsophosHarris, S.
dc.authorsophosDeary, I. J.
dc.authorsophosStarr, J.
dc.authorsophosGatcombe, L.
dc.authorsophosPinna, M.
dc.authorsophosBriggs, S.
dc.authorsophosMartin, L.
dc.authorsophosJaeger, E.
dc.authorsophosSharma-Oates, A.
dc.authorsophosEast, J.
dc.authorsophosLeedham, S.
dc.authorsophosArnold, R.
dc.authorsophosJohnstone, E.
dc.authorsophosWang, H.
dc.authorsophosKerr, D.
dc.authorsophosKerr, R.
dc.authorsophosMaughan, T.
dc.authorsophosKaplan, R.
dc.authorsophosAl-Tassan, N.
dc.authorsophosPalin, K.
dc.authorsophosHänninen, U. A.
dc.authorsophosCajuso, T.
dc.authorsophosTanskanen, T.
dc.authorsophosKondelin, J.
dc.authorsophosKaasinen, E.
dc.authorsophosSarin, A. P.
dc.authorsophosEriksson, J. G.
dc.authorsophosRissanen, H.
dc.authorsophosKnekt, P.
dc.authorsophosPukkala, E.
dc.authorsophosJousilahti, P.
dc.authorsophosSalomaa, V.
dc.authorsophosRipatti, S.
dc.authorsophosPalotie, A.
dc.authorsophosRenkonen-Sinisalo, L.
dc.authorsophosLepistö, A.
dc.authorsophosBöhm, J.
dc.authorsophosMecklin, J. P.
dc.authorsophosBuchanan, D. D.
dc.authorsophosWin, A. K.
dc.authorsophosHopper, J.
dc.authorsophosJenkins, M. E.
dc.authorsophosLindor, N. M.
dc.authorsophosNewcomb, P. A.
dc.authorsophosGallinger, S.
dc.authorsophosDuggan, D.
dc.authorsophosCasey, G.
dc.authorsophosHoffmann, P.
dc.authorsophosNöthen, M. M.
dc.authorsophosJöckel, K. H.
dc.authorsophosEaston, D. F.
dc.authorsophosPharoah, P. D. P.
dc.authorsophosPeto, J.
dc.authorsophosCanzian, F.
dc.authorsophosSwerdlow, A.
dc.authorsophosEeles, R. A.
dc.authorsophosKote-Jarai, Z.
dc.authorsophosMuir, K.
dc.authorsophosPashayan, N.
dc.authorsophosHenderson, B. E.
dc.authorsophosHaiman, C. A.
dc.authorsophosSchumacher, F. R.
dc.authorsophosAl Olama, A. A.
dc.authorsophosBenlloch, S.
dc.authorsophosBerndt, S. I.
dc.authorsophosConti, D. V.
dc.authorsophosWiklund, F.
dc.authorsophosChanock, S.
dc.authorsophosGapstur, S.
dc.authorsophosStevens, V. L.
dc.authorsophosTangen, C. M.
dc.authorsophosBatra, J.
dc.authorsophosClements, J.
dc.authorsophosGronberg, H.
dc.authorsophosSchleutker, J.
dc.authorsophosAlbanes, D.
dc.authorsophosWolk, A.
dc.authorsophosWest, C.
dc.authorsophosMucci, L.
dc.authorsophosCancel-Tassin, G.
dc.authorsophosKoutros, S.
dc.authorsophosSorensen, K. D.
dc.authorsophosGrindedal, E. M.
dc.authorsophosNeal, D. E.
dc.authorsophosHamdy, F. C.
dc.authorsophosDonovan, J. L.
dc.authorsophosTravis, R. C.
dc.authorsophosHamilton, R. J.
dc.authorsophosIngles, S. A.
dc.authorsophosRosenstein, B. S.
dc.authorsophosLu, Y. J.
dc.authorsophosGiles, G. G.
dc.authorsophosKibel, A. S.
dc.authorsophosVega, A.
dc.authorsophosKogevinas, M.
dc.authorsophosPenney, K. L.
dc.authorsophosPark, J. Y.
dc.authorsophosStanford, J. L.
dc.authorsophosCybulski, C.
dc.authorsophosNordestgaard, B. G.
dc.authorsophosMaier, C.
dc.authorsophosKim, J.
dc.authorsophosJohn, E. M.
dc.authorsophosTeixeira, M. R.
dc.authorsophosNeuhausen, S. L.
dc.authorsophosDe Ruyck, K.
dc.authorsophosRazack, A.
dc.authorsophosNewcomb, L. F.
dc.authorsophosGamulin, M.
dc.authorsophosKaneva, R.
dc.authorsophosUsmani, N.
dc.authorsophosClaessens, F.
dc.authorsophosTownsend, P. A.
dc.authorsophosGago-Dominguez, M.
dc.authorsophosRoobol, M. J.
dc.authorsophosMenegaux, F.
dc.authorsophosKhaw, K. T.
dc.authorsophosCannon-Albright, L.
dc.authorsophosPandha, H.
dc.authorsophosThibodeau, S. N.
dc.authorsophosHarkin, A.
dc.authorsophosAllan, K.
dc.authorsophosMcQueen, J.
dc.authorsophosPaul, J.
dc.authorsophosIveson, T.
dc.authorsophosSaunders, M.
dc.authorsophosButterbach, K.
dc.authorsophosChang-Claude, J.
dc.authorsophosHoffmeister, M.
dc.authorsophosBrenner, H.
dc.authorsophosKirac, I.
dc.authorsophosMatošević, P.
dc.authorsophosHofer, P.
dc.authorsophosBrezina, S.
dc.authorsophosGsur, A.
dc.authorsophosCheadle, J. P.
dc.authorsophosAaltonen, L. A.
dc.authorsophosTomlinson, I.
dc.authorsophosHoulston, R. S.
dc.authorsophosDunlop, M. G.
dc.authorsophosThe, Practical consortium
dc.identifier.doi10.1038/s41467-019-09775-w
dc.identifier.pmid31089142
dc.identifier.sophos31763
dc.issue.number1es
dc.journal.titleNature Communicationses
dc.organizationServizo Galego de Saúde::Dirección Xeral de Asistencia Sanitaria::Fundación Pública Galega de Medicina Xenómicaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.rights.accessRightsopenAccesses
dc.subject.decsgrupo de ascendencia continental europea*
dc.subject.decsestudios de casos y controles*
dc.subject.decsgupo de ascendencia continental asiática*
dc.subject.decsfactores de riesgo*
dc.subject.decsmediana edad*
dc.subject.decspatrones de herencia*
dc.subject.decshumanos*
dc.subject.decsestudio de asociación genómica completa*
dc.subject.decssitios genéticos*
dc.subject.decspredisposición genética a la enfermedad*
dc.subject.decsneoplasias colorrectales*
dc.subject.keywordFPGMXes
dc.subject.keywordIDISes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number10es


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Nat Commun. 2019 May 14;10(1):2154

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